PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LATS1	3	PTPN14	5	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Wilson KE (2014), Wilson KE (2014)	3
MOB1B	0	RASSF5	2	bioid	Couzens AL (2013)	1
MOB1B	0	LRCH3	2	bioid	Couzens AL (2013)	1
PTPN14	5	CRLF3	2	affinity chromatography technology	St-Denis N (2016)	1
MOB1B	0	STK38	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Bao Y (2009), Devroe E (2004), Devroe E (2004), Huttlin EL (2017)	4
DOCK8	10	DOCK7	3	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
SAV1	0	PTPN14	5	bioid	Couzens AL (2013)	1
STK4	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	10
STK38	0	MOB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Kohler RS (2010), Kohler RS (2010), Devroe E (2004), Devroe E (2004), Devroe E (2004), So J (2015)	6
STK38L	2	MOB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohler RS (2010), Kohler RS (2010), Devroe E (2004), Devroe E (2004), Devroe E (2004), So J (2015), Hauri S (2013), Huttlin EL (2017)	8
MOB1B	0	PTPN14	5	bioid	Couzens AL (2013)	1
MOB1B	0	PPP6R2	3	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
MOB1B	0	DOCK7	3	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
MOB1B	0	LATS1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Chow A (2010), Chow A (2010), Hergovich A (2006), Hergovich A (2006), Praskova M (2008), Praskova M (2008), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Huttlin EL (2017)	10
DOCK7	3	DOCK6	6	affinity chromatography technology	Couzens AL (2013)	1
PTPN14	5	STK3	1	affinity chromatography technology, affinity chromatography technology	Wang W (2012), Li X (2016)	2
MOB1A	2	MOB2	3	bioid	Couzens AL (2013)	1
RASSF5	2	STK3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Wang J (2011), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	7
STK3	1	MOB1A	2	enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Hirabayashi S (2008), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	4
LATS1	3	APP	1	pull down	Olah J (2011)	1
STK3	1	MOB1B	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid	Bao Y (2009), Bao Y (2009), Couzens AL (2013), Couzens AL (2013)	4
STK38	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohler RS (2010), Bichsel SJ (2004), Bichsel SJ (2004), So J (2015)	4
MOB1B	0	MAP4K4	13	bioid	Couzens AL (2013)	1
CRLF3	2	LRCH2	0	affinity chromatography technology	Couzens AL (2013)	1
CRLF3	2	DOCK6	6	affinity chromatography technology	Couzens AL (2013)	1
MOB1A	2	ANKRD28	1	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
PPP6C	7	PPP6R1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Douglas P (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), St-Denis N (2016), Yadav L (2017)	7
MOB1A	2	PPP6C	7	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
DOCK7	3	LRCH3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Huttlin EL (2017)	3
SOD1	0	MOB1B	0	affinity chromatography technology	Malty RH (2017)	1
LRCH3	2	LRCH2	0	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
LATS2	1	LATS1	3	affinity chromatography technology, bioid	Xiao L (2011), Couzens AL (2013)	2
MOB1A	2	ANKRD52	1	bioid	Couzens AL (2013)	1
PPP6C	7	ANKRD52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Couzens AL (2013), St-Denis N (2016), Yadav L (2017)	4
STK4	1	SAV1	0	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Bae SJ (2015), Huttlin EL (2017), Boldt K (2016)	12
MOB1A	2	LATS1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, bioid	Bothos J (2005), Bothos J (2005), Chow A (2010), Chow A (2010), Kohler RS (2010), Hergovich A (2006), Hergovich A (2006), Couzens AL (2013), Couzens AL (2013)	9
DOCK7	3	LRCH2	0	affinity chromatography technology	Couzens AL (2013)	1
MOB1B	0	ANKRD28	1	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
DOCK8	10	DOCK6	6	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
MOB1A	2	DST	13	bioid	Couzens AL (2013)	1
MOB1B	0	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
MOB1B	0	MOB2	3	bioid	Couzens AL (2013)	1
SKI	3	MOB1A	2	affinity chromatography technology	Rashidian J (2015)	1
LRCH3	2	LRCH1	4	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
MOB1B	0	DOCK8	10	bioid	Couzens AL (2013)	1
MOB1A	2	DOCK7	3	affinity chromatography technology	Couzens AL (2013)	1
SKI	3	MOB1B	0	affinity chromatography technology	Rashidian J (2015)	1
CRLF3	2	DOCK7	3	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013)	2
MOB1A	2	IPO11	0	bioid	Couzens AL (2013)	1
MOB1A	2	PPP6R2	3	bioid	Couzens AL (2013)	1
PPP6R1	4	PPP6R2	3	bioid, bioid	Couzens AL (2013), Couzens AL (2013)	2
PPP6R2	3	ANKRD52	1	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Huttlin EL (2017)	3
MOB1B	0	PPP6R1	4	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
MOB1A	2	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
MOB1A	2	DOCK8	10	bioid	Couzens AL (2013)	1
STK38L	2	MOB1B	0	affinity chromatography technology, imaging technique, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Devroe E (2004), Devroe E (2004), Devroe E (2004), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	7
STK38L	2	MOB1A	2	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Couzens AL (2013), So J (2015), Hauri S (2013), Huttlin EL (2017)	5
SKI	3	LATS2	1	affinity chromatography technology	Rashidian J (2015)	1
PPP6R2	3	APP	1	pull down	Olah J (2011)	1
MOB1B	0	DST	13	bioid	Couzens AL (2013)	1
MOB1A	2	SAV1	0	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
RASSF5	2	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	6
DOCK8	10	LRCH1	4	affinity chromatography technology, two hybrid, affinity chromatography technology	Couzens AL (2013), Rolland T (2014), Huttlin EL (2017)	3
SAV1	0	LATS2	1	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Rashidian J (2015), Bae SJ (2015)	3
MOB1B	0	SAV1	0	affinity chromatography technology	Couzens AL (2013)	1
MOB1B	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
ANKRD28	1	PPP6R1	4	affinity chromatography technology, bioid, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	4
MOB1B	0	PPP6R3	2	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013)	2
MOB1B	0	LATS2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, bioid, affinity chromatography technology	Chow A (2010), Chow A (2010), Bao Y (2009), Bao Y (2009), Couzens AL (2013), Huttlin EL (2017)	6
NT5C2	1	MOB1B	0	two hybrid	Rolland T (2014)	1
SKI	3	STK38L	2	affinity chromatography technology	Rashidian J (2015)	1
CRLF3	2	DOCK8	10	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013)	2
CYLD	2	STK38L	2	affinity chromatography technology	Elliott PR (2016)	1
PPP6R1	4	ANKRD52	1	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
WASHC3	2	MOB1B	0	two hybrid	Rolland T (2014)	1
PPP6R3	2	PPP6R1	4	bioid	Couzens AL (2013)	1
DOCK7	3	LRCH1	4	affinity chromatography technology	Couzens AL (2013)	1
STK3	1	DST	13	affinity chromatography technology	Varjosalo M (2013)	1
PPP6C	7	PPP6R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Douglas P (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017)	8
SAV1	0	LATS1	3	affinity chromatography technology	Guo C (2007)	1
MOB1A	2	LRCH3	2	bioid	Couzens AL (2013)	1
MOB1A	2	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
MOB1A	2	PTPN14	5	bioid	Couzens AL (2013)	1
MOB1A	2	RASSF5	2	bioid	Couzens AL (2013)	1
PPP6R3	2	PPP6R2	3	bioid	Couzens AL (2013)	1
STK3	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	11
STK3	1	SAV1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Guo C (2007), Guo C (2007), Chan EH (2005), Chan EH (2005), Wang J (2011), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	15
DOCK8	10	LRCH3	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Couzens AL (2013), Rolland T (2014), Huttlin EL (2017)	3
LATS2	1	PTPN14	5	bioid	Couzens AL (2013)	1
MOB1B	0	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
APP	1	HSD17B10	1	two hybrid, pull down, affinity chromatography technology	Yan SD (1997), Yan SD (1997), Yan SD (1997)	3
MOB1B	0	APP	1	pull down	Olah J (2011)	1
LATS2	1	STK4	1	affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Couzens AL (2013), Mo XL (2015), Hoa L (2016)	3
MOB1B	0	IPO11	0	bioid	Couzens AL (2013)	1
CYLD	2	MOB1B	0	affinity chromatography technology	Elliott PR (2016)	1
STK3	1	LATS1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Matallanas D (2011), Guo C (2007), Guo C (2007), Hamilton G (2009), Chan EH (2005)	5
LATS2	1	CYLD	2	bioid	Couzens AL (2013)	1
DOCK8	10	LRCH2	0	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
MOB1A	2	PPP6R3	2	affinity chromatography technology	Couzens AL (2013)	1
ANKRD28	1	PPP6R2	3	affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Huttlin EL (2017)	5
MOB1B	0	ANKRD52	1	bioid	Couzens AL (2013)	1
HSD17B10	1	MOB1B	0	affinity chromatography technology	Malty RH (2017)	1
MOB1B	0	CRLF3	2	affinity chromatography technology	Couzens AL (2013)	1
SKI	3	SAV1	0	affinity chromatography technology, affinity chromatography technology	Rashidian J (2015), Rashidian J (2015)	2
MOB1B	0	DOCK6	6	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
ANKRD28	1	PPP6R3	2	affinity chromatography technology, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
MOB1A	2	LRCH1	4	bioid	Couzens AL (2013)	1
LATS1	3	PPP6R3	2	enzymatic study	Chiyoda T (2012)	1
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
MOB1B	0	LRCH2	0	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Huttlin EL (2017)	3
PPP6C	7	ANKRD28	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), St-Denis N (2016), Yadav L (2017)	6
MOB1A	2	LRCH2	0	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
MOB1A	2	PPP6R1	4	bioid	Couzens AL (2013)	1
TNIP1	1	MOB1B	0	two hybrid	Rolland T (2014)	1
MOB1A	2	APP	1	pull down	Olah J (2011)	1
MOB1B	0	LRCH1	4	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
LATS2	1	STK3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bao Y (2009), Couzens AL (2013), Hoa L (2016)	3
LRCH3	2	DOCK6	6	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Huttlin EL (2017)	2
MOB1A	2	DOCK6	6	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
PPP6R3	2	ANKRD52	1	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2
PPP6C	7	PPP6R3	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid, biochemical, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Douglas P (2010), Havugimana PC (2012), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Wan C (2015), St-Denis N (2016), Yadav L (2017)	9
RASSF5	2	RASSF2	2	pull down, two hybrid	Ortiz-Vega S (2002), Rolland T (2014)	2
LRCH3	2	CRLF3	2	affinity chromatography technology	Couzens AL (2013)	1
SKI	3	STK38	0	affinity chromatography technology, affinity chromatography technology	Rashidian J (2015), Rashidian J (2015)	2
MOB1A	2	CRLF3	2	affinity chromatography technology	Couzens AL (2013)	1
CYLD	2	STK38	0	affinity chromatography technology	Elliott PR (2016)	1
MOB1A	2	LATS2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chow A (2010), Chow A (2010), Kohler RS (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Suzuki H (2013), Hoa L (2016), Zhu C (2018)	10
MOB1B	0	PPP6C	7	affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013)	2