PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZBTB22	2	RBM39	2	two hybrid	Rolland T (2014)	1
ZBTB22	2	UBQLN4	2	two hybrid	Stelzl U (2005)	1
UBQLN4	2	MLLT6	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
UBQLN4	2	PIN1	0	two hybrid	Lim J (2006)	1
DNAJA3	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CY (2013), Foerster S (2013), Tong J (2014)	3
FXR2	2	MCRS1	1	two hybrid	Rual JF (2005)	1
MLLT6	2	ZBTB22	2	two hybrid	Rolland T (2014)	1
PIN1	0	ZBTB22	2	two hybrid	Rolland T (2014)	1
EGFR	5	VAPA	1	protein complementation assay, affinity chromatography technology	Deribe YL (2009), Foerster S (2013)	2
EGFR	5	ZBTB22	2	affinity chromatography technology	Yao Z (2017)	1
DNAJA3	2	ZBTB22	2	two hybrid	Rual JF (2005)	1
ZBTB22	2	MCRS1	1	two hybrid	Rolland T (2014)	1
EGFR	5	RBM39	2	affinity chromatography technology	Yao Z (2017)	1
GATA1	1	ZBTB22	2	two hybrid	Ravasi T (2010)	1
AP4M1	2	ZBTB22	2	two hybrid	Wang J (2011)	1
VAPA	1	ZBTB22	2	two hybrid	Rolland T (2014)	1
ZBTB22	2	FXR2	2	two hybrid	Rolland T (2014)	1