PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM5	1	HIST3H2A	0	affinity chromatography technology	Drissi R (2015)	1
ITGA4	4	MCM2	3	affinity chromatography technology	Byron A (2012)	1
CHD1L	5	CBX5	3	affinity chromatography technology	Ahel D (2009)	1
CBX5	3	HIST3H3	0	affinity chromatography technology, unspecified method, x-ray crystallography, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	Quivy JP (2004), Kaustov L (2011), Kaustov L (2011), Bartke T (2010), Li X (2012), Li X (2012), Vermeulen M (2007), Kubota S (2013), Vermeulen M (2010), Vermeulen M (2010), Lacroix M (2008)	11
RNF2	1	HIST3H3	0	affinity chromatography technology, unspecified method	Trojer P (2011), Vermeulen M (2010)	2
MCM2	3	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
HIST3H2A	0	HIST3H3	0	affinity chromatography technology	Pichler G (2012)	1
TCL1A	0	HIST3H2A	0	two hybrid	Rual JF (2005)	1
RNF2	1	HIST3H2A	0	affinity chromatography technology	Cao Q (2014)	1
MCM5	1	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
ITGA4	4	HIST3H3	0	affinity chromatography technology	Byron A (2012)	1
DNTTIP2	1	HIST3H2A	0	pull down	Fujita K (2003)	1
MCM2	3	HIST3H2A	0	affinity chromatography technology	Drissi R (2015)	1
HIST3H2A	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CHD1L	5	HIST3H2A	0	affinity chromatography technology	Gottschalk AJ (2009)	1
ITGA4	4	MCM5	1	affinity chromatography technology	Byron A (2012)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
ITGA4	4	HIST3H2A	0	affinity chromatography technology	Byron A (2012)	1
RNF2	1	MCM5	1	affinity chromatography technology	Cao Q (2014)	1
CBX5	3	HIST3H2A	0	pull down	Nielsen AL (2001)	1