PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRDM6	5	PRDM6	5	affinity chromatography technology	Davis CA (2006)	1
CBX1	0	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
CBFA2T2	3	PRDM6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3A	3	HDAC2	1	affinity chromatography technology, enzymatic study, pull down	Nishioka K (2002), Gyoery I (2003), Li X (2014)	3
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
TCF4	26	PRDM6	5	affinity chromatography technology	Li X (2015)	1
PRDM6	5	HDAC2	1	affinity chromatography technology	Davis CA (2006)	1
HDAC2	1	EHMT1	18	affinity chromatography technology	Bantscheff M (2011)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
TCF4	26	CBFA2T2	3	affinity chromatography technology	Li X (2015)	1
HIST1H3A	3	CBX1	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, x-ray crystallography	Wysocka J (2005), Wysocka J (2005), Kutney SN (2004), Schneider R (2004), Nielsen PR (2002)	5
CBX1	0	EHMT1	18	affinity chromatography technology	Hauri S (2016)	1
PRDM6	5	HDAC1	4	affinity chromatography technology	Davis CA (2006)	1
HDAC1	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
TCF4	26	EP300	36	affinity chromatography technology	Li J (2007)	1
PRDM14	1	PRDM6	5	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
PRDM6	5	HIST1H3A	3	affinity chromatography technology	Davis CA (2006)	1
EHMT1	18	PRDM6	5	affinity chromatography technology	Davis CA (2006)	1
PRDM6	5	CBX1	0	affinity chromatography technology	Davis CA (2006)	1
PRDM6	5	EP300	36	affinity chromatography technology	Davis CA (2006)	1
HIST1H3A	3	EHMT1	18	x-ray crystallography, enzymatic study	Wu H (2010), Huang J (2010)	2
CBFA2T2	3	PRDM14	1	two hybrid, two hybrid, affinity chromatography technology	Ravasi T (2010), Rolland T (2014), Huttlin EL (2017)	3
SYCE3	0	PRDM6	5	affinity chromatography technology	Huttlin EL (2017)	1
PRDM6	5	HDAC3	5	affinity chromatography technology	Davis CA (2006)	1
HDAC3	5	CBFA2T2	3	affinity chromatography technology	Amann JM (2005)	1
HIST1H3A	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Nishioka K (2002), Li X (2014), Hein MY (2015)	3
HIST1H3A	3	HDAC3	5	pull down	Li X (2014)	1