PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS3	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
HIST1H3A	3	DDB1	6	affinity chromatography technology, pull down	Higa LA (2006), Higa LA (2006)	2
VDR	2	CREBBP	29	imaging technique, pull down	Saramaeki A (2006), Jimenez-Lara AM (1999)	2
DTL	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Higa LA (2006), Higa LA (2006), Sertic S (2013), Shibata E (2014), Hein MY (2015), Shibata E (2011), Higa LA (2006), Higa LA (2006)	9
FBXO7	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
COPS2	5	NDUFA8	1	genetic interference	Horlbeck MA (2018)	1
DCAF8	1	COPS7A	0	biochemical	Kristensen AR (2012)	1
HIST1H4A	0	CUL1	7	biochemical	Kristensen AR (2012)	1
CDC16	2	PPCS	3	genetic interference	Horlbeck MA (2018)	1
DDA1	1	DCAF8	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
PSMC5	4	PSMA6	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
EGLN3	0	PSMC1	2	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	COPS4	0	affinity chromatography technology	Bhansali M (2014)	1
COPS8	2	COPS7A	0	biochemical, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Huang X (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
FBXO7	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015)	3
DDA1	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Jin J (2006), Hein MY (2015)	3
NFKBIA	0	COPS2	5	affinity chromatography technology	Schweitzer K (2007)	1
DCUN1D1	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
DENR	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
NCOR1	9	VDR	2	pull down, two hybrid, two hybrid, pull down, two hybrid, pull down, pull down	Puccetti E (2002), Tagami T (1998), Kim JY (2009), Kim JY (2009), Polly P (2000), Herdick M (2000), Herdick M (2000)	7
GFER	1	COPS2	5	affinity chromatography technology	Wang Y (2004)	1
ANAPC13	0	CDC16	2	biochemical, biochemical, affinity chromatography technology, genetic interference	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	4
COPS2	5	FEM1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	COPS6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009)	5
NEDD8	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
SIN3B	5	SIN3A	13	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	COPS3	1	affinity chromatography technology	Bennett EJ (2010)	1
PSMC3	0	KDM1A	2	two hybrid	Rolland T (2014)	1
COPS2	5	SEPT2	4	biochemical	Havugimana PC (2012)	1
TRIM25	5	NCOR1	9	affinity chromatography technology	Choudhury NR (2017)	1
CUL4A	2	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Ito T (2010), Bennett EJ (2010), Liu Y (2015), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	14
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
COPS2	5	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
KLHDC3	1	COPS6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC16	2	NCOR1	9	affinity chromatography technology	Huttlin EL (2017)	1
COPS7B	0	FEM1B	1	affinity chromatography technology	Huttlin EL (2017)	1
APBB3	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	PSMC5	4	affinity chromatography technology	Rodriguez J (2016)	1
CPSF1	6	COPS5	0	affinity chromatography technology	Menon S (2008)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
COPS2	5	NIF3L1	0	affinity chromatography technology, pull down, two hybrid	Akiyama H (2003), Akiyama H (2003), Akiyama H (2003)	3
COPS8	2	DCAF4	3	affinity chromatography technology	Huttlin EL (2017)	1
KLHDC3	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Huttlin EL (2017)	3
DCAF4L2	3	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wang H (2016)	2
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
CUL4B	8	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
COPS5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	11
COPS7A	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015), Huttlin EL (2017)	3
DDB1	6	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
COPS4	0	COPS7B	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
CUL4B	8	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Ji Q (2014), Ji Q (2014), Ji Q (2014), Ji Q (2014)	4
COPS4	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
PSMA6	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bloom J (2006), Bloom J (2006), Bloom J (2006), Bennett EJ (2010)	4
DDB2	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
COPS5	0	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Bianchi E (2003), Yi C (2005), Lu G (2014), Li X (2015), Huttlin EL (2017), Zou S (2016)	7
GFER	1	KDM1A	2	genetic interference	Horlbeck MA (2018)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
COPS7A	0	DCAF4	3	affinity chromatography technology	Hein MY (2015)	1
FBXO6	0	COPS5	0	affinity chromatography technology	Liu B (2012)	1
PRKD1	7	COPS5	0	enzymatic study	Uhle S (2003)	1
DDB1	6	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Jin J (2006), Emberley ED (2012)	3
ING2	0	COPS2	5	affinity chromatography technology, pull down	Fegers I (2007), Fegers I (2007)	2
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
DCAF8	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
SYCE3	0	CUL2	3	affinity chromatography technology	Huttlin EL (2017)	1
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
COPS5	0	FBXL14	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SEPHS1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2003), Lockwood WW (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	5
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
COPS6	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
CRBN	2	COPS7B	0	affinity chromatography technology	Kroenke J (2014)	1
ANAPC13	0	ANAPC1	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
SKP2	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Nie L (2011), Bennett EJ (2010)	2
KRAS	1	COPS5	0	genetic interference	Luo J (2009)	1
NCOR1	9	SIN3A	13	pull down, affinity chromatography technology	Khan MM (2001), Farhana L (2007)	2
DCAF11	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
WRAP73	1	COPS4	0	affinity chromatography technology	Ewing RM (2007)	1
CUL3	17	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
CRBN	2	KDM1A	2	two hybrid	Weimann M (2013)	1
SYCE3	0	FEM1B	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL5	3	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
GPS1	1	TP53	0	biochemical	Bech-Otschir D (2001)	1
CUL5	1	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	ERCC8	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXL5	3	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
JUN	0	CSNK2A1	15	pull down, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Uhle S (2003)	3
COPS2	5	SIN3B	5	pull down	Moehren U (2004)	1
ERCC8	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
GRK5	7	COPS7A	0	affinity chromatography technology	Wu Z (2012)	1
THRA	2	EP300	36	affinity chromatography technology, affinity chromatography technology	De Luca A (2003), De Luca A (2003)	2
SKP2	2	AR	3	imaging technique, affinity chromatography technology	Li B (2014), Li B (2014)	2
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Enchev RI (2010), Olma MH (2009), Havugimana PC (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017)	6
DCUN1D1	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
COPS6	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Bennett EJ (2010), Rozen S (2015)	3
RFWD2	0	DDB2	1	affinity chromatography technology	Olma MH (2009)	1
CUL4B	8	XRN2	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
FBXO6	0	PSMC5	4	affinity chromatography technology	Liu B (2012)	1
IRF5	0	COPS2	5	affinity chromatography technology	Korczeniewska J (2012)	1
SYCE3	0	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
KLHL10	1	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
IRF5	0	COPS3	1	affinity chromatography technology	Korczeniewska J (2012)	1
COPS2	5	XRN2	1	genetic interference	Horlbeck MA (2018)	1
LRR1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
PSMA6	1	GPS1	1	affinity chromatography technology	Huang X (2005)	1
COPS2	5	NR2F1	9	pull down	Dressel U (1999)	1
COPS4	0	CTNNBL1	1	genetic interference	Horlbeck MA (2018)	1
DCAF4L2	3	GPS1	1	affinity chromatography technology	Wang H (2016)	1
IRF5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Korczeniewska J (2012), Korczeniewska J (2012)	2
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
DTL	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
CSNK2A1	15	COPS5	0	affinity chromatography technology	Bhansali M (2014)	1
DDB1	6	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Min KW (2005), Emberley ED (2012), Olma MH (2009)	5
KLHL10	1	CUL3	17	affinity chromatography technology	Huttlin EL (2017)	1
COPS2	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Eckey M (2013), Eckey M (2013)	2
SKP2	2	ANAPC1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
COPS5	0	XRN2	1	affinity chromatography technology, genetic interference	Bennett EJ (2010), Horlbeck MA (2018)	2
EGLN3	0	IBTK	3	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
FBXO6	0	GPS1	1	affinity chromatography technology	Liu B (2012)	1
NUCKS1	0	COPS2	5	biochemical	Wan C (2015)	1
FBXW4	0	COPS7B	0	affinity chromatography technology	Lockwood WW (2013)	1
EGLN3	0	CSNK2A1	15	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
DDA1	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	4
EGLN3	0	ERCC3	3	affinity chromatography technology	Rodriguez J (2016)	1
GRK5	7	NR2F1	9	affinity chromatography technology	Wu Z (2012)	1
DET1	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
NAP1L1	2	COPS2	5	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Eckey M (2007), Eckey M (2007), Eckey M (2007), Eckey M (2007), Eckey M (2007)	5
COPS6	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
COPS9	1	COPS8	2	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
IRF5	0	COPS5	0	affinity chromatography technology	Korczeniewska J (2012)	1
FBXW4	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
TP53	0	NFKBIA	0	affinity chromatography technology, two hybrid	Chang NS (2002), Chang NS (2002)	2
CUL4B	8	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	4
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
COPS2	5	NCOR1	9	pull down	Polly P (2000)	1
CDC16	2	EP300	36	affinity chromatography technology	Turnell AS (2005)	1
PSMC3	0	PSMC5	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ishizuka T (2001), Ishizuka T (2001), Um JW (2010), Lee SH (2012), Lee SH (2012), Divald A (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
CUL3	17	CPSF1	6	affinity chromatography technology	Bennett EJ (2010)	1
DCAF8	1	COPS3	1	affinity chromatography technology	Olma MH (2009)	1
NDUFA8	1	PSMC1	2	genetic interference	Horlbeck MA (2018)	1
CUL4A	2	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
COPS3	1	FEM1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DET1	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Wertz IE (2004), Vitari AC (2011), Lu G (2014), Lu G (2014), Pick E (2007), Huttlin EL (2017)	7
COPS8	2	COPS3	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Min KW (2005), Enchev RI (2010), Sharon M (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
COPS8	2	COPS2	5	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Yang X (2002), Huang X (2005), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
IRF5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Korczeniewska J (2012)	2
TP53	0	SIN3B	5	affinity chromatography technology, two hybrid	Bansal N (2011), Bansal N (2011)	2
THRB	1	TP53	0	affinity chromatography technology	Shih A (2001)	1
CUL4A	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Pick E (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006)	7
TRIM25	5	SKP2	2	affinity chromatography technology	Choudhury NR (2017)	1
GPS1	1	SKP2	2	affinity chromatography technology	Lyapina S (2001)	1
NEDD8	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
PSMC3	0	AR	3	affinity chromatography technology, affinity chromatography technology	Satoh T (2009), Satoh T (2009)	2
DET1	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMA6	1	PSMC1	2	affinity chromatography technology, biochemical, biochemical	Huang X (2005), Havugimana PC (2012), Wan C (2015)	3
ERCC8	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Groisman R (2006)	8
COPS4	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
KLHL10	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
KLHDC3	1	NEDD8	0	affinity chromatography technology	Huttlin EL (2015)	1
DDB1	6	DCAF11	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Angers S (2006), Jin J (2006), He YJ (2006), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	8
ANAPC13	0	SKA3	3	genetic interference	Horlbeck MA (2018)	1
COPS2	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang X (2005), Bennett EJ (2010), Olma MH (2009), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	6
COPS6	0	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
KRAS	1	COPS7B	0	affinity chromatography technology	Hein MY (2015)	1
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
COPS2	5	GAPVD1	6	biochemical	Havugimana PC (2012)	1
COPS5	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Sertic S (2013), Higa LA (2006), Higa LA (2006)	5
RFWD2	0	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
CUL5	1	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
EPB41L1	4	COPS3	1	biochemical	Kristensen AR (2012)	1
CUL4A	2	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Kapetanaki MG (2006), Matsuda N (2005), Higa LA (2006), Nag A (2001), Takedachi A (2010), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), Groisman R (2003), Groisman R (2003), Hrecka K (2007), Shiyanov P (1999), Shiyanov P (1999), Bennett EJ (2010), Kulaksiz G (2005), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Groisman R (2003), Huttlin EL (2015), Hein MY (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Fantini D (2017)	31
GFER	1	XRN2	1	genetic interference	Horlbeck MA (2018)	1
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
IP6K1	5	DDB1	6	affinity chromatography technology, pull down	Rao F (2014), Rao F (2014)	2
GFER	1	COPS5	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Lu C (2002), Lu C (2002), Lu C (2002), Chen X (2003), Chen X (2003), Wang Y (2004)	6
COPS3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Yang X (2002), Enchev RI (2010), Huang X (2005), Kapelari B (2000), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Rozen S (2015), Huttlin EL (2017)	13
CRBN	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Q (2016), Eichner R (2016), Huttlin EL (2017), Kroenke J (2014)	4
TRIM25	5	NAP1L1	2	affinity chromatography technology	Choudhury NR (2017)	1
NEDD8	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	CPSF1	6	affinity chromatography technology, affinity chromatography technology	Sagawa F (2011), Sagawa F (2011)	2
DCUN1D1	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Shibata E (2011), Higa LA (2006)	3
KRAS	1	COPS8	2	genetic interference	Luo J (2009)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
COPS2	5	PPCS	3	genetic interference	Horlbeck MA (2018)	1
FBXO6	0	COPS7B	0	affinity chromatography technology	Liu B (2012)	1
FBXO17	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
COPS4	0	XRN2	1	genetic interference	Horlbeck MA (2018)	1
DDB1	6	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Behrends C (2010), Pick E (2007), Pick E (2007), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Jin J (2006), Wan C (2015)	10
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
CUL4A	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Rao F (2014), Rao F (2014), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	13
PRAME	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Costessi A (2011), Costessi A (2011), Bennett EJ (2010), Costessi A (2012), Costessi A (2012), Wadelin FR (2013), Costessi A (2011), Huttlin EL (2015), Huttlin EL (2017)	9
NPM1	0	HIST1H4A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan V (2005), Shuaib M (2010), Shuaib M (2010), Kleiner RE (2018)	4
COPS2	5	PSMC3	0	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
HIST1H3A	3	CUL4A	2	affinity chromatography technology, pull down	Higa LA (2006), Higa LA (2006)	2
CRBN	2	COPS7A	0	affinity chromatography technology	Kroenke J (2014)	1
THRA	2	COPS2	5	two hybrid, pull down, pull down, pull down	Dressel U (1999), Dressel U (1999), Dressel U (1999), Polly P (2000)	4
JUN	0	NCOR1	9	imaging technique	Subbaramaiah K (2007)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
MED4	2	TRIM25	5	bioid	Lambert JP (2015)	1
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
CUL4A	2	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	APPBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
CREBBP	29	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Senyuk V (2005), Perissi V (1999), Pasheva E (2004), Shen WF (2001), Kouskouti A (2005), Kouskouti A (2005), Yasuda J (2004), Tropberger P (2013), Das C (2009)	9
NEDD8	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
TP53	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology	Latini P (2011), Latini P (2011)	2
DCAF4	3	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	HIST1H4A	0	affinity chromatography technology	Liu B (2012)	1
COPS6	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
HIST1H3A	3	NCOR1	9	pull down	Yu J (2003)	1
ERCC3	3	PSMC5	4	affinity chromatography technology, pull down	Weeda G (1997), Weeda G (1997)	2
RFWD2	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
NFKBIA	0	COPS3	1	affinity chromatography technology	Lee JH (2013)	1
RFWD2	0	DCAF11	2	affinity chromatography technology	Olma MH (2009)	1
THRB	1	COPS2	5	two hybrid	Dressel U (1999)	1
DDA1	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
CUL2	3	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW4	0	COPS3	1	affinity chromatography technology	Lockwood WW (2013)	1
GRK5	7	DDB2	1	affinity chromatography technology	Wu Z (2012)	1
EP300	36	COPS2	5	enzymatic study, pull down	Eckey M (2013), Eckey M (2013)	2
COPS2	5	TRIP11	5	affinity chromatography technology	Kob R (2007)	1
COPS6	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Higa LA (2006)	4
DCAF4L2	3	DDB1	6	affinity chromatography technology, affinity chromatography technology	Wang H (2016), Wang H (2016)	2
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
COPS8	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
DTL	0	GPS1	1	affinity chromatography technology	Higa LA (2006)	1
GRK5	7	COPS4	0	affinity chromatography technology	Wu Z (2012)	1
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
NCOR1	9	HIST1H4A	0	pull down	Hartman HB (2005)	1
COPS7A	0	BTBD2	4	affinity chromatography technology	Hein MY (2015)	1
COPS6	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
KRAS	1	ANAPC1	1	genetic interference	Luo J (2009)	1
COPS2	5	COPS2	5	genetic interference	Horlbeck MA (2018)	1
FBXO7	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	NCOR1	9	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yoo JY (2012), Yoo JY (2012), Yoo JY (2012)	3
CUL4A	2	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
CUL2	3	GPS1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001)	2
CUL5	1	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Lee JE (2011), Bennett EJ (2010), Lyapina S (2001), Reitsma JM (2017)	6
ING1	2	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Vieyra D (2002), Vieyra D (2002)	2
UBE2M	0	UBA3	0	affinity chromatography technology, enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Ewing RM (2007), Huang DT (2004), Souphron J (2008), Huang DT (2005), Huang DT (2009), Gong L (1999), Souphron J (2008), Huttlin EL (2017), Mo Z (2016)	9
CUL3	17	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Huttlin EL (2017)	3
RFWD2	0	CUL2	3	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	MED4	2	affinity chromatography technology	Kob R (2007)	1
TRIM25	5	DCAF6	0	affinity chromatography technology	Choudhury NR (2017)	1
DCUN1D1	0	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	DCAF8	1	affinity chromatography technology	Olma MH (2009)	1
CUL4A	2	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Boldt K (2016)	7
COPS2	5	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001), Huttlin EL (2017)	3
KRAS	1	COPS4	0	genetic interference	Luo J (2009)	1
EGLN3	0	NDUFA8	1	affinity chromatography technology	Rodriguez J (2016)	1
MED23	3	PPCS	3	genetic interference	Horlbeck MA (2018)	1
DET1	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
COPS2	5	ERCC3	3	affinity chromatography technology	Kob R (2007)	1
NEDD8	0	PSMA6	1	affinity chromatography technology	Norman JA (2006)	1
DCUN1D1	0	FEM1B	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS2	5	MED23	3	affinity chromatography technology	Kob R (2007)	1
PSMD5	0	PSMC3	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CUL3	17	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	5
NCOR1	9	EP300	36	affinity chromatography technology	Cowger JJ (2006)	1
IRF5	0	COPS4	0	affinity chromatography technology	Korczeniewska J (2012)	1
COPS5	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
FBXW4	0	COPS7A	0	affinity chromatography technology	Lockwood WW (2013)	1
CSNK2A1	15	XRN2	1	enzymatic study	Zhang M (2011)	1
PSMA6	1	PSMD5	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
CUL1	7	COPS8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Menon S (2008), Bennett EJ (2010), Enchev RI (2012), Reitsma JM (2017)	4
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
NCOR1	9	IRF5	0	affinity chromatography technology	Feng D (2010)	1
COPS6	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
COPS2	5	EPB41L1	4	biochemical	Kristensen AR (2012)	1
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
TRIM25	5	PFKFB2	4	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Groisman R (2006)	5
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
ING1	2	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuzmichev A (2002), Kuzmichev A (2002), Skowyra D (2001), Skowyra D (2001), Skowyra D (2001), Nikolaev AY (2004), Nikolaev AY (2004)	7
COPS2	5	NPM1	0	affinity chromatography technology	Kob R (2007)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
CUL3	17	PSMC5	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
FBXO7	1	PSMA6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Vingill S (2016), Teixeira FR (2016)	3
NPM1	0	EIF3E	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Chen R (2013), Wang J (2011), Hein MY (2015)	3
COPS7B	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKD1	7	COPS2	5	enzymatic study	Uhle S (2003)	1
GRK5	7	COPS2	5	affinity chromatography technology	Wu Z (2012)	1
FBXW4	0	COPS6	0	affinity chromatography technology	Lockwood WW (2013)	1
COPS2	5	IP6K1	5	pull down	Rao F (2014)	1
WRAP73	1	COPS2	5	affinity chromatography technology	Ewing RM (2007)	1
KLHL13	0	COPS2	5	affinity chromatography technology	Sowa ME (2009)	1
COPS2	5	UBA3	0	genetic interference	Horlbeck MA (2018)	1
SLAIN2	2	APPBP2	3	affinity chromatography technology	Hein MY (2015)	1
COPS6	0	CRBN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Olma MH (2009), Kroenke J (2014)	3
EGLN3	0	NAP1L1	2	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
COPS6	0	FBXL14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
RAB5C	2	COPS2	5	affinity chromatography technology	Hein MY (2015)	1
COPS2	5	COPS7B	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
KDM1A	2	SIN3A	13	affinity chromatography technology	You A (2001)	1
DDB1	6	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009)	3
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
ANAPC13	0	ANAPC4	0	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Chang L (2015), Yamaguchi M (2015), Huttlin EL (2017)	6
CSNK2A1	15	COPS4	0	affinity chromatography technology	Bhansali M (2014)	1
IRF8	4	GPS1	1	affinity chromatography technology	Li S (2011)	1
COPS2	5	NR0B1	2	two hybrid, pull down	Altincicek B (2000), Altincicek B (2000)	2
FBXO7	1	PRAME	2	enzymatic study	Teixeira FR (2016)	1
COPS5	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
CUL4B	8	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Hein MY (2015)	4
AR	3	NCOR1	9	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Masiello D (2004), Song LN (2004), Cheng S (2002), Cheng S (2002), Cheng S (2002), Hodgson MC (2005), Hodgson MC (2005), Cheng S (2002), Cheng S (2002), Song LN (2004), Wu Y (2006), Wu Y (2006), Fu M (2002), Altintas DM (2011), Cui J (2011), Hodgson MC (2005), Hodgson MC (2005), Zhu P (2006), Qi J (2013), Lempiaeinen JK (2017), Tan G (2017)	21
KRAS	1	IBTK	3	genetic interference	Luo J (2009)	1
CUL3	17	XRN2	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	AR	3	affinity chromatography technology	Chen S (2013)	1
EGLN3	0	ANAPC1	1	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
COPS2	5	DCAF6	0	affinity chromatography technology	Huttlin EL (2015)	1
KLHL10	1	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	UBA3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li T (2006), Norman JA (2006), Bennett EJ (2010)	3
IBTK	3	COPS4	0	affinity chromatography technology	Pisano A (2015)	1
CUL2	3	UBE2M	0	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	COPS2	5	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
APBB3	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	CUL5	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
UBE2M	0	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS3	1	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHL10	1	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	HIST1H3A	3	enzymatic study, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Chen Y (2006), Forneris F (2005), Shi YJ (2005), Lee MG (2005), Metzger E (2010), Lin Y (2010)	6
UIMC1	4	COPS2	5	affinity chromatography technology	Sowa ME (2009)	1
DDA1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Olma MH (2009), Olma MH (2009)	3
NFKBIA	0	GPS1	1	affinity chromatography technology	Lee JH (2013)	1
COPS2	5	EHBP1L1	5	biochemical	Havugimana PC (2012)	1
KLHL10	1	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
NPM1	0	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan V (2005), Haindl M (2008), Shuaib M (2010), Shuaib M (2010)	4
FBXW4	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Lockwood WW (2013), Lockwood WW (2013)	2
DCUN1D1	0	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
AR	3	NR0B1	2	affinity chromatography technology, affinity chromatography technology	Holter E (2002), Agoulnik IU (2003)	2
EGLN3	0	PSMC3	0	affinity chromatography technology	Rodriguez J (2016)	1
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
ANAPC4	0	CDC16	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Masuda K (2015), Boekhout M (2015), Huttlin EL (2017)	14
UBE2M	0	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
BTBD2	4	COPS6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
DENR	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
DET1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Pick E (2007), Pick E (2007), Jin J (2006), Huttlin EL (2017)	8
THRA	2	TRIP11	5	affinity chromatography technology, pull down	Chang KH (1997), Chang KH (1997)	2
MED23	3	MED4	2	bioid, affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015), Lambert JP (2015)	3
NDUFA8	1	KDM1A	2	two hybrid	Weimann M (2013)	1
DET1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	COPS8	2	affinity chromatography technology	Liu B (2012)	1
APBB3	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
KDM1A	2	COPS2	5	biochemical	Wan C (2015)	1
CUL5	1	LRR1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
KRAS	1	MED4	2	affinity chromatography technology	Hein MY (2015)	1
COPS2	5	PMPCA	1	biochemical	Havugimana PC (2012)	1
KRAS	1	ANAPC4	0	genetic interference	Luo J (2009)	1
COPS2	5	TP53	0	affinity chromatography technology	Huang X (2005)	1
TRIM25	5	UIMC1	4	affinity chromatography technology	Choudhury NR (2017)	1
COPS2	5	YTHDC1	8	genetic interference	Horlbeck MA (2018)	1
COPS7B	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CTNNBL1	1	PPCS	3	genetic interference	Horlbeck MA (2018)	1
TRIM25	5	IBTK	3	affinity chromatography technology	Choudhury NR (2017)	1
DCAF11	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
COPS4	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
CUL3	17	IBTK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Pisano A (2015), Pisano A (2015), Pisano A (2015), Huttlin EL (2017)	5
VDR	2	MED23	3	affinity chromatography technology	Rachez C (1999)	1
EGLN3	0	IRS2	6	affinity chromatography technology	Rodriguez J (2016)	1
FBXO7	1	NEDD8	0	affinity chromatography technology	Teixeira FR (2016)	1
KRAS	1	CDC16	2	genetic interference	Luo J (2009)	1
TRIM25	5	BTBD1	2	affinity chromatography technology	Choudhury NR (2017)	1
IRF8	4	COPS5	0	affinity chromatography technology	Li S (2011)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS8	2	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Boldt K (2016)	3
DDB2	1	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chang SW (2012), Chang SW (2012), Chen HH (2017), Chen HH (2017)	4
CUL4A	2	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Min KW (2005), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	10
CUL1	7	SENP8	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Gastaldello S (2010), Gastaldello S (2010), Christmann M (2013), Gastaldello S (2010)	4
COPS3	1	FBXO17	1	affinity chromatography technology	Olma MH (2009)	1
UBE2M	0	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	DCAF8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017)	5
RFWD2	0	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	PSMC5	4	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
COPS3	1	DTL	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Higa LA (2006)	2
GRK5	7	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
RFWD2	0	CUL1	7	affinity chromatography technology	Olma MH (2009)	1
FBXO6	0	COPS7A	0	affinity chromatography technology	Liu B (2012)	1
COPS2	5	HIST1H4A	0	pull down	Eckey M (2007)	1
MED4	2	TRIP11	5	affinity chromatography technology	Boldt K (2016)	1
DCUN1D1	0	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS2	5	VDR	2	pull down, two hybrid	Polly P (2000), Polly P (2000)	2
UBE2M	0	CUL1	7	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Huang G (2011), Huang G (2011), Kim AY (2008), Ponyeam W (2012), Ohki Y (2009), Zhou W (2017), Mo Z (2016)	7
DENR	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	FEM1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
CUL3	17	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huang X (2016), Huttlin EL (2017)	5
COPS2	5	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SENP8	0	CUL2	3	enzymatic study	Mendoza HM (2003)	1
GPS1	1	SENP8	0	far western blotting, far western blotting	Christmann M (2013), Christmann M (2013)	2
COPS3	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Stotland A (2012), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
CUL4B	8	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
COPS7A	0	COPS2	5	affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
LRR1	1	COPS8	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2017)	2
COPS2	5	PSMD5	0	affinity chromatography technology	Kob R (2009)	1
RFWD2	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
TP53	0	ERCC3	3	pull down, affinity chromatography technology, pull down, pull down, pull down	Wang XW (1995), Wang XW (1995), Qadri I (2002), Qadri I (2002), Leveillard T (1996)	5
NEDD8	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
EGLN3	0	GFER	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL1	7	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Reitsma JM (2017)	6
SLAIN2	2	YTHDC1	8	affinity chromatography technology	Hein MY (2015)	1
CUL4A	2	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009)	7
FBXO17	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB2	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
CUL3	17	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	COPS2	5	affinity chromatography technology	Kroenke J (2014)	1
ACTR10	0	SKA3	3	genetic interference	Horlbeck MA (2018)	1
APBB3	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
RFWD2	0	COPS8	2	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
FBXL14	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	DDB1	6	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
COPS8	2	CRBN	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Kroenke J (2014)	2
CUL5	1	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
CUL4B	8	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016)	8
DDB1	6	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
645455	0	COPS2	5	affinity chromatography technology	Hein MY (2015)	1
COPS3	1	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
CUL1	7	FBXL14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	3
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
CSNK2A1	15	KDM1A	2	affinity chromatography technology	Peng B (2015)	1
GRK5	7	PSMC1	2	affinity chromatography technology	Wu Z (2012)	1
RFWD2	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS5	0	JUN	0	two hybrid, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Claret FX (1996), Claret FX (1996), Claret FX (1996), Bianchi E (2000), Yun HM (2010)	5
645455	0	CPSF1	6	affinity chromatography technology	Hein MY (2015)	1
DENR	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS2	5	PFKFB2	4	biochemical	Havugimana PC (2012)	1
IBTK	3	COPS2	5	affinity chromatography technology	Pisano A (2015)	1
CRBN	2	DDA1	1	affinity chromatography technology	Kroenke J (2014)	1
ABCA1	5	COPS5	0	affinity chromatography technology, affinity chromatography technology	Azuma Y (2009), Azuma Y (2009)	2
DCUN1D1	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	CUL5	1	enzymatic study	Duda DM (2008)	1
NCOR1	9	THRB	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, far western blotting, affinity chromatography technology	Tagami T (2009), Loinder K (2004), Miyazaki W (2004), Jeyakumar M (2007), Jeyakumar M (2007), Hoerlein AJ (1995), Krogsdam AM (2002), DiRenzo J (1997), Liu YY (2015)	9
DCAF8	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
COPS3	1	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
FBXL5	3	KLHDC3	1	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	CSNK2A1	15	pull down, far western blotting, affinity chromatography technology	Yamaguchi Y (1998), Yamaguchi Y (1998), Jung SY (2005)	3
NPM1	0	PSMC5	4	affinity chromatography technology	Chen R (2013)	1
EP300	36	COPS6	0	two hybrid	Stelzl U (2005)	1
DDB1	6	GPS1	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Jin J (2006), Emberley ED (2012), Cavadini S (2016)	3
NFKBIA	0	NCOR1	9	affinity chromatography technology	Aguilera C (2004)	1
IRF8	4	COPS6	0	affinity chromatography technology	Li S (2011)	1
COPS2	5	EIF3E	1	affinity chromatography technology	Huang X (2005)	1
COPS5	0	HIST1H4A	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
FBXO7	1	PSMC1	2	affinity chromatography technology	Teixeira FR (2016)	1
PRKD1	7	JUN	0	enzymatic study, enzymatic study	Hurd C (2002), Uhle S (2003)	2
COPS4	0	SKA3	3	genetic interference	Horlbeck MA (2018)	1
COPS2	5	ANAPC4	0	affinity chromatography technology	Kob R (2009)	1
CUL4A	2	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2017)	4
BTBD1	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	COPS7B	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	5
CUL4B	8	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Higa LA (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
FBXL14	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
COPS6	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
GPS1	1	IP6K1	5	pull down	Rao F (2014)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
ERCC8	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Olma MH (2009)	3
COPS2	5	ABCA1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Azuma Y (2009), Zhang M (2016), Zhang M (2016)	3
COPS2	5	ANAPC1	1	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
ERCC8	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
SIN3A	13	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sun JM (2007), Sun JM (2007), Havugimana PC (2012), Wan C (2015)	4
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
CUL3	17	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
KDM1A	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Tsai WW (2008), Tsai WW (2008), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007)	7
CUL3	17	HIST1H4A	0	affinity chromatography technology	Bennett EJ (2010)	1
AR	3	ERCC3	3	affinity chromatography technology, pull down	Chymkowitch P (2011), Chymkowitch P (2011)	2
COPS8	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
COPS3	1	CSNK2A1	15	far western blotting	Uhle S (2003)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
DCAF4	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
DDB2	1	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology	Fantini D (2017), Fantini D (2017)	2
CUL4A	2	DCAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Jin J (2006), Chen HH (2017)	5
COPS6	0	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Olma MH (2009)	5
FBXO6	0	NPM1	0	affinity chromatography technology	Liu B (2012)	1
DCAF4L2	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang H (2016)	3
COPS6	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Enchev RI (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CUL2	3	SKP2	2	affinity chromatography technology	Kimura Y (2007)	1
DDB1	6	COPS8	2	affinity chromatography technology, pull down	Angers S (2006), Emberley ED (2012)	2
ANAPC13	0	COPS2	5	genetic interference	Horlbeck MA (2018)	1
COPS5	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL5	1	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
FBXL5	3	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
GRK5	7	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
IRF8	4	COPS4	0	affinity chromatography technology	Li S (2011)	1
FEM1B	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2017)	3
IBTK	3	COPS3	1	affinity chromatography technology	Pisano A (2015)	1
MED23	3	EP300	36	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
PSMC1	2	PSMD5	0	pull down, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Kaneko T (2009), Havugimana PC (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
EP300	36	ING1	2	affinity chromatography technology	Vieyra D (2002)	1
COPS7A	0	EPB41L1	4	biochemical	Kristensen AR (2012)	1
DDB1	6	COPS4	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Angers S (2006), Jin J (2006), Emberley ED (2012), Olma MH (2009)	4
PSMC3	0	TP53	0	affinity chromatography technology	Kulikov R (2010)	1
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
KLHDC3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS6	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
KLHDC3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
COPS3	1	CRBN	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Kroenke J (2014)	2
DCUN1D1	0	CUL2	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Heir P (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Chen K (2016)	13
CUL3	17	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Wimuttisuk W (2014), Maerki S (2009), Huttlin EL (2017)	6
SKP2	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
ERCC3	3	GTF2H2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Jeronimo C (2007), Humbert S (1994), Humbert S (1994), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	9
UBE2M	0	TP53	0	enzymatic study	Xirodimas DP (2004)	1
AR	3	SIN3B	5	affinity chromatography technology	Zhu P (2006)	1
COPS5	0	CRBN	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kroenke J (2014)	2
VDR	2	MED4	2	affinity chromatography technology	Rachez C (1999)	1
AR	3	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Dai Y (2008), Minges JT (2013), Zhong J (2014), Fu M (2000), McClurg UL (2016), Tan G (2017)	6
ANAPC13	0	COPS5	0	genetic interference	Horlbeck MA (2018)	1
LRR1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS3	1	DCAF4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	PSMC1	2	affinity chromatography technology	Liu B (2012)	1
NFKBIA	0	DCAF6	0	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	FEM1B	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL5	1	HIST1H4A	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL13	0	COPS4	0	affinity chromatography technology	Sowa ME (2009)	1
COPS5	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Ebina M (2013), Ebina M (2013), Rozen S (2015), Rozen S (2015)	5
COPS8	2	COPS5	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Olma MH (2009), Asare Y (2013), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	9
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
ERCC8	1	EP300	36	affinity chromatography technology	Fousteri M (2006)	1
CUL4B	8	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Hein MY (2015), Yang Y (2015)	4
GPS1	1	COPS7A	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015), Hein MY (2015), Huang X (2016)	6
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
DET1	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Hein MY (2015)	6
DDB1	6	CRBN	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Angers S (2006), Ito T (2010), Chamberlain PP (2014), Liu Y (2015), Diaz-Rodriguez E (2016), Xu Q (2016), Xu G (2013), Nguyen TV (2016), Nguyen TV (2016), Eichner R (2016), Matyskiela ME (2018), Kroenke J (2014)	12
COPS2	5	MAP3K10	2	two hybrid, pull down, enzymatic study	Eckey M (2003), Eckey M (2003), Eckey M (2003)	3
CUL4B	8	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Olma MH (2009)	2
CSNK2A1	15	SEPT2	4	enzymatic study	Zhang M (2011)	1
TRIM25	5	CUL5	1	affinity chromatography technology	Choudhury NR (2017)	1
CTNNBL1	1	MED23	3	genetic interference	Horlbeck MA (2018)	1
PSMC3	0	PSMA6	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PSMA6	1	COPS5	0	affinity chromatography technology	Huang X (2005)	1
NFKBIA	0	DENR	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED4	2	WRAP73	1	bioid	Lambert JP (2015)	1
CUL4A	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017)	6
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
COPS7A	0	CSNK2A1	15	affinity chromatography technology, far western blotting, enzymatic study	Uhle S (2003), Uhle S (2003), Uhle S (2003)	3
CUL2	3	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Kamura T (2004), Kamura T (2004), Kamura T (2004)	5
ANAPC1	1	ANAPC4	0	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	9
DCAF4L2	3	COPS5	0	affinity chromatography technology	Wang H (2016)	1
SIN3A	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Murphy M (1999), Murphy M (1999), Murphy M (1999), Zilfou JT (2001)	4
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
PSMC5	4	PSMC1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hartmann-Petersen R (2001), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
EP300	36	NFKBIA	0	affinity chromatography technology	Shin DH (2009)	1
COPS6	0	COPS7A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	15
APBB3	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Higa LA (2006)	5
DCAF4L2	3	COPS7B	0	affinity chromatography technology	Wang H (2016)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
DDB2	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Hein MY (2015)	4
EP300	36	ING2	0	affinity chromatography technology	Wang Y (2006)	1
CUL3	17	COPS8	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Schumacher FR (2015)	2
AR	3	GTF2H2	0	pull down	Chymkowitch P (2011)	1
COPS4	0	UBA3	0	genetic interference	Horlbeck MA (2018)	1
VDR	2	EP300	36	imaging technique, imaging technique	Kim S (2005), Kim S (2005)	2
MED4	2	CTNNBL1	1	two hybrid	Rolland T (2014)	1
CUL2	3	HIST1H4A	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	FEM1B	1	affinity chromatography technology	Olma MH (2009)	1
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
SENP8	0	NEDD8	0	pull down, x-ray crystallography, enzymatic study, x-ray crystallography, enzymatic study	Wu K (2003), Shen LN (2005), Engels IH (2009), Reverter D (2005), Shen LN (2005)	5
COPS8	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
DCAF4L2	3	COPS8	2	affinity chromatography technology	Wang H (2016)	1
PRAME	2	COPS2	5	affinity chromatography technology	Huttlin EL (2015)	1
DDA1	1	ERCC8	1	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	CDC16	2	affinity chromatography technology	Kob R (2009)	1
TRIM25	5	ANAPC1	1	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
CDC16	2	CREBBP	29	affinity chromatography technology	Turnell AS (2005)	1
COPS8	2	COPS6	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
EP300	36	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
ING2	0	SIN3B	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
GFER	1	COPS8	2	affinity chromatography technology	Wang Y (2004)	1
KRAS	1	COPS2	5	genetic interference	Luo J (2009)	1
COPS6	0	CPSF1	6	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Keuss MJ (2016)	2
GPS1	1	COPS7B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Stotland A (2012), Havugimana PC (2012), Huang X (2016), Huttlin EL (2017)	4
MED23	3	CREBBP	29	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
DDB1	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Jin J (2006), Groisman R (2003), Groisman R (2003), Meulenbroek EM (2012), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Chitale S (2017), Ohtake F (2007)	10
COPS5	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
APBB3	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
RFWD2	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Higa LA (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Lu G (2014)	7
UIMC1	4	UBA3	0	affinity chromatography technology	Sowa ME (2009)	1
EIF3E	1	COPS6	0	two hybrid, affinity chromatography technology	Hoareau Alves K (2002), Hoareau Alves K (2002)	2
CUL2	3	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS2	5	SEPHS1	0	biochemical	Havugimana PC (2012)	1
CPSF1	6	GPS1	1	affinity chromatography technology	Menon S (2008)	1
DCUN1D1	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li T (2006), Norman JA (2006), Huttlin EL (2017)	3
ERCC8	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
CUL4A	2	SENP8	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Gastaldello S (2010), Gastaldello S (2010), Gastaldello S (2010)	3
DDB1	6	DCAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Jin J (2006), Chen HH (2017), Chen HH (2017), Chen HH (2017)	6
TRIM25	5	COPS2	5	affinity chromatography technology	Choudhury NR (2017)	1
GFER	1	GPS1	1	affinity chromatography technology	Wang Y (2004)	1
DCUN1D1	0	KLHL13	0	affinity chromatography technology	Bennett EJ (2010)	1
CPSF1	6	COPS2	5	affinity chromatography technology	Menon S (2008)	1
CSNK2A1	15	NAP1L1	2	biochemical, enzymatic study	Havugimana PC (2012), Rodriguez P (2000)	2
DDA1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
APBB3	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DCAF6	0	CUL4B	8	affinity chromatography technology	Jin J (2006)	1
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
DCAF4L2	3	COPS3	1	affinity chromatography technology	Wang H (2016)	1
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
COPS6	0	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CREBBP	29	PSMC5	4	affinity chromatography technology	Koues OI (2008)	1
COPS8	2	DTL	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS4	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	3
VDR	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Stambolsky P (2010), Stambolsky P (2010)	2
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
COPS2	5	BTBD2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIN3A	13	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
COPS7B	0	COPS7A	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
DDA1	1	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
DDA1	1	DDB2	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Hein MY (2015)	2
UBE2M	0	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei J (2012), Hein MY (2015)	3
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
DCUN1D1	0	UBE2M	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Scott DC (2011), Huang G (2014), Huang G (2014), Keuss MJ (2016), Huttlin EL (2017), Zhou H (2017), Zhou H (2017), Zhou H (2017)	13
COPS5	0	DCAF8	1	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
IRF8	4	COPS2	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cohen H (2000), Cohen H (2000), Cohen H (2000), Li S (2011)	4
DCAF4	3	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
THRA	2	CUL1	7	two hybrid	Albers M (2005)	1
TRIM25	5	FEM1B	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL4A	2	DCAF11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), He YJ (2006), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Huttlin EL (2017), Lo JY (2017)	10
CUL5	1	BTBD1	2	affinity chromatography technology	Bennett EJ (2010)	1
BTBD1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
NPM1	0	SLAIN2	2	affinity chromatography technology	Chen R (2013)	1
COPS2	5	SIN3A	13	affinity chromatography technology, pull down, pull down, two hybrid	Dressel U (1999), Moehren U (2004), Moehren U (2004), Moehren U (2004)	4
COPS2	5	HIST1H3A	3	pull down	Eckey M (2007)	1
RFWD2	0	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Jin J (2006), He YJ (2006), Olma MH (2009), Lu G (2014), Lu G (2014)	6
EGLN3	0	NEDD8	0	affinity chromatography technology	Rodriguez J (2016)	1
DCAF4	3	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
VDR	2	PSMC5	4	two hybrid, two hybrid	Masuyama H (1998), Albers M (2005)	2
COPS2	5	SKA3	3	genetic interference	Horlbeck MA (2018)	1
UBE2M	0	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
LRR1	1	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
NCOR1	9	CREBBP	29	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006), Cowger JJ (2006)	4
COPS5	0	UBA3	0	genetic interference	Horlbeck MA (2018)	1
KLHL10	1	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	KDM1A	2	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Bennett EJ (2010)	3
ACTR10	0	ANAPC13	0	genetic interference	Horlbeck MA (2018)	1
CUL3	17	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
DDB2	1	ERCC8	1	affinity chromatography technology	Groisman R (2003)	1
CUL5	1	DCAF11	2	affinity chromatography technology	Bennett EJ (2010)	1
DCAF8	1	DDB1	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Olma MH (2009), Klein CJ (2014), Jin J (2006), Huttlin EL (2017)	6
DTL	0	TP53	0	affinity chromatography technology, enzymatic study	Banks D (2006), Banks D (2006)	2
COPS4	0	COPS7A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sharon M (2009), Luke-Glaser S (2007), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016)	13
SKP2	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	AR	3	two hybrid, pull down, pull down, genetic interference, affinity chromatography technology, pull down	Kim J (2005), Fronsdal K (1998), Ishitani K (2003), Aarnisalo P (1998), Andersen RJ (2010), Fronsdal K (1998)	6
COPS3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CRBN	2	GPS1	1	affinity chromatography technology	Kroenke J (2014)	1
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
DENR	2	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
IRF5	0	COPS8	2	affinity chromatography technology	Korczeniewska J (2012)	1
THRB	1	PSMC5	4	two hybrid, two hybrid, two hybrid	Lee JW (1995), Monden T (1997), Albers M (2005)	3
COPS2	5	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Yang X (2002), Choo YY (2011), Bennett EJ (2010), Huttlin EL (2015), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	7
FBXO6	0	PSMC3	0	affinity chromatography technology	Liu B (2012)	1
COPS6	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	9
EGLN3	0	JUN	0	affinity chromatography technology	Rodriguez J (2016)	1
AR	3	DCAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsai TC (2005), Tsai TC (2005), Tsai TC (2005), Tsai TC (2005), Chen HH (2017), Chen HH (2017)	6
PSMC1	2	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ING1	2	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung KM (2002), Garkavtsev I (1998), Zhu Z (2009)	3
EGLN3	0	DDA1	1	affinity chromatography technology	Rodriguez J (2016)	1
XRN2	1	PRAME	2	two hybrid	Lehner B (2004)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
COPS2	5	COPS9	1	affinity chromatography technology	Rozen S (2015)	1
DCAF4L2	3	COPS4	0	affinity chromatography technology	Wang H (2016)	1
VDR	2	JUN	0	pull down	Towers TL (1999)	1
ING1	2	COPS2	5	affinity chromatography technology, pull down	Fegers I (2007), Fegers I (2007)	2
EGLN3	0	NCOR1	9	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	DDB1	6	affinity chromatography technology	Rodriguez J (2016)	1
DET1	2	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Angers S (2006), Jin J (2006), Pick E (2007), Huttlin EL (2017)	5
CUL5	1	FBXO17	1	affinity chromatography technology	Bennett EJ (2010)	1
DET1	2	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS2	5	SLAIN2	2	biochemical	Havugimana PC (2012)	1
CUL5	1	COPS3	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
TRIM25	5	SIN3A	13	affinity chromatography technology	Choudhury NR (2017)	1
CUL4A	2	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Hein MY (2015)	7
DDA1	1	DCAF6	0	affinity chromatography technology	Olma MH (2009)	1
CUL4B	8	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015), Higa LA (2006)	3
EGLN3	0	GAPVD1	6	affinity chromatography technology	Rodriguez J (2016)	1
NEDD8	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
UBE2M	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
DENR	2	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	KDM1A	2	affinity chromatography technology, bioid	Choi H (2016), Lempiaeinen JK (2017)	2
SYCE3	0	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS2	5	JUN	0	affinity chromatography technology	Huang X (2005)	1
TRIM25	5	APBB3	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	IP6K1	5	affinity chromatography technology	Choudhury NR (2017)	1
DCAF4L2	3	COPS6	0	affinity chromatography technology	Wang H (2016)	1
WRAP73	1	GPS1	1	affinity chromatography technology	Ewing RM (2007)	1
COPS2	5	CTNNBL1	1	genetic interference	Horlbeck MA (2018)	1
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
TRIM25	5	PSMC5	4	affinity chromatography technology	Choudhury NR (2017)	1
DDB1	6	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down	Ji Q (2014), Ji Q (2014), Ji Q (2014)	3
DDB1	6	DCAF4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Jin J (2006), Huttlin EL (2017)	4
DET1	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO17	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO6	0	EIF3E	1	affinity chromatography technology	Liu B (2012)	1
EP300	36	NAP1L1	2	two hybrid	Shikama N (2000)	1
LRR1	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS5	0	DDB2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), He YJ (2006), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
TRIM25	5	KLHDC3	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO6	0	COPS3	1	affinity chromatography technology	Liu B (2012)	1
CUL5	1	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
DENR	2	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	EHBP1L1	5	affinity chromatography technology	Choudhury NR (2017)	1
BTBD1	2	LRR1	1	affinity chromatography technology	Wimuttisuk W (2014)	1
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
CUL1	7	XRN2	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
APPBP2	3	CUL2	3	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010)	2
CUL5	1	DDB2	1	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	COPS8	2	affinity chromatography technology	Olma MH (2009)	1
RAB5C	2	LRR1	1	affinity chromatography technology	Hein MY (2015)	1
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
EGLN3	0	NFKBIA	0	affinity chromatography technology	Rodriguez J (2016)	1
ANAPC1	1	CDC16	2	biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Hutchins JR (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
FEM1B	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Bennett EJ (2010), Kamura T (2004), Kamura T (2004)	4
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
LRR1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL2	3	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	3
COPS2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Huang X (2005), Uhle S (2003)	2
FBXO6	0	COPS4	0	affinity chromatography technology	Liu B (2012)	1
TP53	0	ING2	0	affinity chromatography technology	Pedeux R (2005)	1
NEDD8	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
CTNNBL1	1	NPM1	0	affinity chromatography technology	Ganesh K (2011)	1
ING2	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Huttlin EL (2017)	4
PRAME	2	KDM1A	2	affinity chromatography technology	Costessi A (2012)	1
CUL5	1	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
GPS1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stotland A (2012), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Scherer PC (2016)	5
CUL3	17	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
COPS7B	0	APPBP2	3	affinity chromatography technology	Huttlin EL (2017)	1
DDB2	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
COPS3	1	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DDB2	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	DCAF8	1	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	LRR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	5
MED23	3	KDM1A	2	affinity chromatography technology	Lambert JP (2015)	1
CREBBP	29	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
FBXW4	0	GPS1	1	affinity chromatography technology	Lockwood WW (2013)	1
TRIM25	5	ERCC3	3	affinity chromatography technology	Choudhury NR (2017)	1
CUL1	7	FBXL5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vashisht AA (2009), Salahudeen AA (2009), Liu B (2012), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Chen ZW (2015), Wu WD (2016), Huttlin EL (2017)	9
TRIP11	5	PSMC5	4	two hybrid	Choi HS (1996)	1
DET1	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Jin J (2006), Huttlin EL (2017)	2
TRIM25	5	ERCC8	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO7	1	UBE2M	0	enzymatic study	Teixeira FR (2016)	1
FBXL14	2	COPS3	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXL14	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMC3	0	PSMC1	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CUL1	7	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
ANAPC13	0	COPS4	0	genetic interference	Horlbeck MA (2018)	1
MED4	2	ERCC3	3	affinity chromatography technology	Lambert JP (2015)	1
THRA	2	NCOR1	9	affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, pull down	Rietveld LE (2002), Ishii S (2004), Tagami T (1998), Tagami T (1998), Safer JD (1998), Jeyakumar M (2007), Jeyakumar M (2007), Albers M (2005), Hoerlein AJ (1995)	9
GRK5	7	SIN3A	13	affinity chromatography technology	Wu Z (2012)	1
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
COPS2	5	PSMC1	2	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
COPS5	0	FBXL5	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
EPB41L1	4	COPS4	0	biochemical	Kristensen AR (2012)	1
COPS2	5	IRS2	6	biochemical	Havugimana PC (2012)	1
CUL3	17	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
CSNK2A1	15	NPM1	0	enzymatic study	Zhang M (2011)	1
FBXO7	1	PSMC5	4	biochemical, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016)	2
TRIM25	5	DDB1	6	affinity chromatography technology	Choudhury NR (2017)	1
DDA1	1	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Lu G (2014)	2
COPS7A	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
COPS2	5	PSMA6	1	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
UBA3	0	KDM1A	2	two hybrid	Weimann M (2013)	1
DET1	2	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
EP300	36	FBXL5	3	two hybrid	Wang J (2011)	1
ACTR10	0	COPS2	5	genetic interference	Horlbeck MA (2018)	1
FBXW4	0	COPS4	0	affinity chromatography technology	Lockwood WW (2013)	1
PRKD1	7	TP53	0	enzymatic study	Uhle S (2003)	1
EP300	36	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Brackertz M (2006), Faiola F (2005), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Deng L (2001), Wang F (2010), Ghizzoni M (2012), Loven MA (2004), Wong K (2005), Murakami M (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Saha RN (2007), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Dornan D (2003), Ji A (2003), Fu M (2005), Suganuma T (2002), Kim JH (2006), Lopes da Rosa J (2013), Wright DG (2016), Du C (2017), Yi P (2017)	29
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
ANAPC13	0	UBA3	0	genetic interference	Horlbeck MA (2018)	1
ERCC8	1	COPS8	2	affinity chromatography technology, affinity chromatography technology, biochemical	Groisman R (2003), Groisman R (2003), Groisman R (2006)	3
PSMC5	4	PSMD5	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
KLHL10	1	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
MED4	2	SKA3	3	bioid	Lambert JP (2015)	1
SEPT2	4	DDB2	1	biochemical	Kristensen AR (2012)	1
JUN	0	AR	3	affinity chromatography technology, affinity chromatography technology	Sato N (1997), Sato N (1997)	2
GTF2H2	0	ERCC8	1	affinity chromatography technology	Henning KA (1995)	1
EGLN3	0	SKA3	3	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	DDA1	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
COPS6	0	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009)	4
FBXL5	3	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXW4	0	COPS8	2	affinity chromatography technology	Lockwood WW (2013)	1
COPS8	2	FEM1B	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS2	5	SENP8	0	affinity chromatography technology, far western blotting	Christmann M (2013), Christmann M (2013)	2
UBE2M	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
KLHL10	1	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study	Perissi V (1999), Pasheva E (2004), Yasuda J (2004)	3
AR	3	COPS2	5	two hybrid, pull down, affinity chromatography technology	Moehren U (2007), Moehren U (2007), Moehren U (2007)	3
DDB2	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003), Kulaksiz G (2005), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	6
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
PSMC5	4	MED4	2	affinity chromatography technology	Huttlin EL (2017)	1
NAP1L1	2	NPM1	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	COPS2	5	affinity chromatography technology	Rodriguez J (2016)	1
COPS7A	0	KLHL13	0	affinity chromatography technology	Hein MY (2015)	1
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
CUL4B	8	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
GRK5	7	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012), Wu Z (2012)	3
DCAF8	1	COPS4	0	biochemical	Kristensen AR (2012)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
FBXO7	1	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
BTBD2	4	TP53	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
CUL5	1	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	PRKD1	7	affinity chromatography technology, enzymatic study	Uhle S (2003), Uhle S (2003)	2
WRAP73	1	COPS3	1	affinity chromatography technology	Ewing RM (2007)	1
DCAF11	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Hein MY (2015), Huttlin EL (2017)	3
KDM1A	2	EP300	36	affinity chromatography technology	Garcia-Bassets I (2007)	1
FBXO6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
COPS3	1	COPS9	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Huttlin EL (2017)	6
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CUL5	1	NAP1L1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	3
APBB3	2	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
COPS8	2	COPS4	0	biochemical, affinity chromatography technology, biochemical, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
CUL3	17	PSMC1	2	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
SYCE3	0	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
DCAF8	1	DCAF11	2	biochemical	Kristensen AR (2012)	1
EPB41L1	4	COPS5	0	biochemical	Kristensen AR (2012)	1
DCAF4L2	3	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Wang H (2016)	3
COPS2	5	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IRF5	0	COPS6	0	affinity chromatography technology	Korczeniewska J (2012)	1
PRKD1	7	IBTK	3	enzymatic study, affinity chromatography technology	Janda E (2011), Janda E (2011)	2
LRR1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
CACTIN	3	COPS2	5	genetic interference	Horlbeck MA (2018)	1
IP6K1	5	CUL4A	2	affinity chromatography technology	Rao F (2014)	1
DDA1	1	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
COPS9	1	GPS1	1	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
COPS5	0	SKA3	3	genetic interference	Horlbeck MA (2018)	1
KRAS	1	UBE2M	0	genetic interference	Luo J (2009)	1
COPS2	5	GTF2H2	0	affinity chromatography technology	Kob R (2007)	1
TRIM25	5	RFWD2	0	affinity chromatography technology	Choudhury NR (2017)	1
ERCC8	1	GPS1	1	affinity chromatography technology, affinity chromatography technology	Groisman R (2003), Groisman R (2003)	2
TP53	0	NCOR1	9	affinity chromatography technology, imaging technique	Dohi Y (2008), Ali A (2013)	2