PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
CCDC8	1	RP2	3	affinity chromatography technology	Hanson D (2014)	1
ESR1	0	8339	0	pull down	Nalvarte I (2010)	1
VHL	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid	Lai Y (2011), Lai Y (2011), Duan DR (1995), Minervini G (2015)	4
OBSL1	9	VCP	6	affinity chromatography technology	Hanson D (2014)	1
SOX6	1	TRIP12	20	two hybrid, affinity chromatography technology, enzymatic study	An CI (2013), An CI (2013), An CI (2013)	3
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
ERG	1	TRIP12	20	pull down	Wang S (2016)	1
ESR1	0	VCP	6	pull down	Nalvarte I (2010)	1
ALYREF	0	TRIP12	20	biochemical	Havugimana PC (2012)	1
SIRT7	1	CAPN1	3	affinity chromatography technology	Tsai YC (2012)	1
RNF168	0	UBE2D1	0	pull down	OConnor HF (2015)	1
MEPCE	1	TRIP12	20	affinity chromatography technology	Jeronimo C (2007)	1
OBSL1	9	GNL3	3	affinity chromatography technology	Hanson D (2014)	1
TRIP12	20	MYC	2	pull down, affinity chromatography technology	Chen D (2010), Chen D (2010)	2
SIRT7	1	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Tsai YC (2012), Jiang L (2017), Jiang L (2017), Jiang L (2017), Jiang L (2017), Jiang L (2017)	6
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
MYC	2	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SNW1	0	TRIP12	20	affinity chromatography technology	Lleres D (2010)	1
MEPCE	1	KPNA6	1	affinity chromatography technology	Jeronimo C (2007)	1
OBSL1	9	EXOSC9	2	affinity chromatography technology	Hanson D (2014)	1
VCP	6	TRIP12	20	affinity chromatography technology	Yu CC (2013)	1
SMAD9	0	TRIP12	20	two hybrid	Colland F (2004)	1
BCAT1	6	TRIP12	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP11	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Maertens GN (2010), Maertens GN (2010), Ma H (2012), Hein MY (2015)	7
ESR1	0	SRPK2	1	affinity chromatography technology	Tarallo R (2011)	1
MYC	2	EIF3I	0	affinity chromatography technology	Koch HB (2007)	1
ESR1	0	ALYREF	0	pull down, affinity chromatography technology	Nalvarte I (2010), Han SJ (2016)	2
RPA1	0	TRIP12	20	affinity chromatography technology	Marechal A (2014)	1
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
CDKN2A	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2012), Li Z (2012), Li Z (2012), Li Z (2012)	4
MEPCE	1	KPNA1	5	affinity chromatography technology	Jeronimo C (2007)	1
TRIP12	20	KPNA5	1	affinity chromatography technology	Hauri S (2016)	1
KBTBD7	3	OBSL1	9	affinity chromatography technology	Behrends C (2010)	1
TEAD2	2	TRIP12	20	affinity chromatography technology	Li X (2015)	1
8339	0	TRIP12	20	bioid	Lambert JP (2015)	1
TRIP12	20	NMI	3	affinity chromatography technology, affinity chromatography technology, pull down	Li Z (2012), Li Z (2012), Li Z (2012)	3
CCDC8	1	VCP	6	affinity chromatography technology	Hanson D (2014)	1
TRIP12	20	UBE2D1	0	pull down, pull down, pull down, pull down	Park Y (2008), Schwarz SE (1998), An CI (2013), Park Y (2009)	4
TRIP12	20	TRADD	0	affinity chromatography technology, affinity chromatography technology	Chio II (2012), Chio II (2012)	2
RPA3	2	TRIP12	20	affinity chromatography technology	Marechal A (2014)	1
ESR1	0	UBE4B	5	two hybrid	Arroyo R (2015)	1
USP7	14	RNF168	0	pull down, affinity chromatography technology	Zhu Q (2015), Zhu Q (2015)	2
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
MEPCE	1	KPNA5	1	affinity chromatography technology	Jeronimo C (2007)	1
CDKN2A	1	TEAD2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
OBSL1	9	UBC	7	affinity chromatography technology	Hanson D (2014)	1
SIRT7	1	TRIP12	20	affinity chromatography technology	Tsai YC (2012)	1
MYC	2	NMI	3	affinity chromatography technology, pull down, two hybrid	Li H (2002), Li H (2002), Bannasch D (1999)	3
TEAD2	2	MECP2	36	affinity chromatography technology	Li X (2015)	1
CAPN1	3	TRIP12	20	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	UBC	7	affinity chromatography technology	Hanson D (2014)	1
TRIP12	20	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Chen D (2010), Chen D (2010), Chen D (2010), Chio II (2012), Li Z (2012), Li Z (2012), Lo D (2014), Lee S (2016)	8
SMARCE1	1	TRIP12	20	affinity chromatography technology	Keppler BR (2010)	1
OBSL1	9	TRIP12	20	affinity chromatography technology	Hanson D (2014)	1
MTNR1B	1	TRIP12	20	two hybrid	Benleulmi-Chaachoua A (2016)	1
RNF168	0	TRIP12	20	affinity chromatography technology	Gudjonsson T (2012)	1
UBE2D1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
OBSL1	9	ALYREF	0	affinity chromatography technology	Hanson D (2014)	1
USP7	14	TRIP12	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Liu X (2016), Liu X (2016)	3
RPA3	2	USP7	14	affinity chromatography technology	Marechal A (2014)	1
RP2	3	TRIP12	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCE1	1	ESR1	0	affinity chromatography technology, pull down, pull down, pull down	Belandia B (2002), Belandia B (2002), Kiskinis E (2006), Flajollet S (2007)	4
CDKN2A	1	GNL3	3	affinity chromatography technology, pull down, affinity chromatography technology	Lo D (2014), Lo D (2014), Lo D (2014)	3
CLSTN1	0	TRIP12	20	two hybrid	Nakayama M (2002)	1
SIRT7	1	CDK9	3	affinity chromatography technology	Jiang L (2017)	1
EED	1	GNL3	3	affinity chromatography technology	Cao Q (2014)	1
CCDC8	1	TRIP12	20	affinity chromatography technology	Hanson D (2014)	1
USP11	3	TRIP12	20	affinity chromatography technology	Sowa ME (2009)	1
TRIP12	20	GNL3	3	affinity chromatography technology	Lo D (2014)	1
EED	1	TRIP12	20	affinity chromatography technology	Cao Q (2014)	1
KBTBD7	3	TRIP12	20	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	CEP19	0	two hybrid	Rolland T (2014)	1
SIRT7	1	GNL3	3	affinity chromatography technology	Tsai YC (2012)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
IFI16	1	GNL3	3	affinity chromatography technology	Diner BA (2015)	1
SIRT7	1	SNW1	0	affinity chromatography technology	Tsai YC (2012)	1
MYC	2	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kanazawa S (2003), Bres V (2009), Eberhardy SR (2001), Gargano B (2007), Jaenicke LA (2016)	5
OPCML	1	TRIP12	20	affinity chromatography technology	Huttlin EL (2017)	1
8339	0	MECP2	36	bioid	Lambert JP (2015)	1
TRIP12	20	UBC	7	affinity chromatography technology	Park Y (2009)	1
USP7	14	MYC	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Tavana O (2016), Tavana O (2016), Tavana O (2016), Tavana O (2016)	4
TRIP12	20	RPL39	0	affinity chromatography technology	Hauri S (2016)	1
OBSL1	9	SNW1	0	affinity chromatography technology	Hanson D (2014)	1
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
EED	1	ALYREF	0	affinity chromatography technology	Cao Q (2014)	1
KBTBD7	3	SIRT7	1	affinity chromatography technology	Hein MY (2015)	1
CDK9	3	TRIP12	20	affinity chromatography technology	Jeronimo C (2007)	1
MEPCE	1	ALYREF	0	affinity chromatography technology	Jeronimo C (2007)	1
TRIP12	20	KPNA1	5	affinity chromatography technology	Hauri S (2016)	1
RPA2	0	UBC	7	affinity chromatography technology	Marechal A (2014)	1
PHF8	6	TRIP12	20	affinity chromatography technology	Hein MY (2015)	1
UBE2L3	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
ESR1	0	TRIP12	20	affinity chromatography technology	Tarallo R (2011)	1
SIRT7	1	VCP	6	affinity chromatography technology	Tsai YC (2012)	1
IFI16	1	USP7	14	affinity chromatography technology	Diner BA (2015)	1
TRIP12	20	NAE1	0	affinity chromatography technology, enzymatic study	Park Y (2008), Park Y (2008)	2
MEPCE	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	7
PHF8	6	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Q (2016), Wang Q (2016), Wang Q (2016), Wang Q (2016), Wang Q (2016)	5
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
SNW1	0	KPNA1	5	affinity chromatography technology	Lleres D (2010)	1
RPA1	0	UBC	7	affinity chromatography technology	Marechal A (2014)	1
CFTR	5	KPNA6	1	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	TRIP12	20	affinity chromatography technology	Wang X (2006)	1
VHL	0	TRIP12	20	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	EIF3I	0	affinity chromatography technology	Tsai YC (2012)	1
SNW1	0	MYC	2	affinity chromatography technology, affinity chromatography technology	Bres V (2009), Bres V (2009)	2
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
RPA3	2	UBC	7	affinity chromatography technology	Marechal A (2014)	1
VHL	0	UBE2D1	0	pull down	Gao C (2010)	1
UBE4B	5	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2004), Matsumoto M (2004), Boehm S (2011), Takahata M (2008), Morreale G (2009), Fernandez-Saiz V (2010), Fernandez-Saiz V (2010), Raman M (2015), Wang T (2016), Huttlin EL (2017)	10
VHL	0	RPA3	2	affinity chromatography technology	Ewing RM (2007)	1
RPA2	0	VCP	6	affinity chromatography technology	Inano S (2017)	1
SNW1	0	RPA1	0	affinity chromatography technology	Lleres D (2010)	1
RPA2	0	USP7	14	affinity chromatography technology	Marechal A (2014)	1
MECP2	36	TRIP12	20	affinity chromatography technology	Huttlin EL (2017)	1
CEP19	0	GNL3	3	bioid	Gupta GD (2015)	1
CEP19	0	TRIP12	20	bioid	Gupta GD (2015)	1
FAM46A	2	TRIP12	20	affinity chromatography technology	Hein MY (2015)	1
EXOSC9	2	TRIP12	20	affinity chromatography technology	Hein MY (2015)	1
TRIP12	20	KPNA6	1	affinity chromatography technology	Hauri S (2016)	1
TRIP12	20	UBE2L3	1	pull down	Schwarz SE (1998)	1
EIF3I	0	TRIP12	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
SRPK2	1	TRIP12	20	enzymatic study	Lipp JJ (2015)	1
SIRT7	1	ALYREF	0	affinity chromatography technology	Tsai YC (2012)	1
CDKN2A	1	UBE4B	5	pull down	Souza-Rodrigues E (2007)	1
RPA2	0	TRIP12	20	affinity chromatography technology	Marechal A (2014)	1
ESR1	0	GNL3	3	affinity chromatography technology	Tarallo R (2011)	1
MYC	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Hwang IY (2012), Hwang IY (2012)	2
SRPK2	1	EED	1	enzymatic study	Lipp JJ (2015)	1
SNW1	0	CDK9	3	affinity chromatography technology, affinity chromatography technology	Bres V (2009), Lleres D (2010)	2
CCDC8	1	RPA1	0	affinity chromatography technology	Hanson D (2014)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
USP7	14	EED	1	pull down, affinity chromatography technology	de Bie P (2010), Cao Q (2014)	2
MECP2	36	SMARCE1	1	affinity chromatography technology	Harikrishnan KN (2005)	1
CDKN2A	1	TRADD	0	affinity chromatography technology	Chio II (2012)	1
UBC	7	ALYREF	0	affinity chromatography technology	Matsumoto M (2005)	1
UBE4B	5	TRIP12	20	pull down	Park Y (2008)	1
CFTR	5	EIF3I	0	affinity chromatography technology	Pankow S (2015)	1
MTNR1A	1	TRIP12	20	two hybrid	Benleulmi-Chaachoua A (2016)	1
CARNS1	0	TRIP12	20	two hybrid	Nakayama M (2002)	1
PTF1A	1	TRIP12	20	two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Hanoun N (2014), Hanoun N (2014), Hanoun N (2014), Hanoun N (2014)	4
IFI16	1	TRIP12	20	affinity chromatography technology	Diner BA (2015)	1
KPNA1	5	USP7	14	affinity chromatography technology	Hein MY (2015)	1
SIRT7	1	USP11	3	affinity chromatography technology	Tsai YC (2012)	1
RPA1	0	USP7	14	affinity chromatography technology	Marechal A (2014)	1
RNF168	0	UBC	7	pull down, pull down, pull down, pull down, pull down	Panier S (2012), Feng L (2012), Thorslund T (2015), Luijsterburg MS (2017), Luijsterburg MS (2017)	5
TEAD2	2	USP11	3	affinity chromatography technology	Li X (2015)	1