PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHPF	1	MED4	2	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	TRIP11	5	bioid	Guo Z (2014)	1
BFSP2	1	TRIP11	5	affinity chromatography technology	Huttlin EL (2017)	1
TMEM17	0	USO1	1	bioid	Gupta GD (2015)	1
ARNT	1	NCOA1	6	affinity chromatography technology, two hybrid, pull down	Beischlag TV (2002), Beischlag TV (2002), Beischlag TV (2002)	3
THRA	2	NCOA1	6	affinity chromatography technology, pull down, two hybrid, pull down, pull down	Sharma D (2000), Lopez GN (1999), Tagami T (1998), Safer JD (1998), Kurtev V (2004)	5
USO1	1	TRIP11	5	affinity chromatography technology	van Zuylen WJ (2012)	1
NCOA1	6	TRIP11	5	affinity chromatography technology	Jung SY (2005)	1
CDH1	4	EXOC3	2	bioid	Guo Z (2014)	1
TRIP11	5	ATG16L1	1	affinity chromatography technology	Boldt K (2016)	1
TMEM17	0	EXOC3	2	bioid	Gupta GD (2015)	1
THRA	2	COPS2	5	two hybrid, pull down, pull down, pull down	Dressel U (1999), Dressel U (1999), Dressel U (1999), Polly P (2000)	4
COPS2	5	TRIP11	5	affinity chromatography technology	Kob R (2007)	1
COPS2	5	MED4	2	affinity chromatography technology	Kob R (2007)	1
THRA	2	TRIP11	5	affinity chromatography technology, pull down	Chang KH (1997), Chang KH (1997)	2
MYH6	12	TRIP11	5	affinity chromatography technology	Hein MY (2015)	1
COPS2	5	PSMC5	4	affinity chromatography technology, affinity chromatography technology	Kob R (2009), Kob R (2009)	2
MED4	2	TRIP11	5	affinity chromatography technology	Boldt K (2016)	1
TRIP11	5	ARNT	1	pull down, x-ray crystallography	Partch CL (2009), Partch CL (2009)	2
TMEM17	0	TRIP11	5	bioid	Gupta GD (2015)	1
ATXN1L	0	TRIP11	5	two hybrid	Lim J (2006)	1
YWHAE	0	TRIP11	5	affinity chromatography technology	Gloeckner CJ (2007)	1
RB1	2	TRIP11	5	two hybrid, affinity chromatography technology, pull down	Chang KH (1997), Chang KH (1997), Chang KH (1997)	3
RB1	2	ARNT	1	affinity chromatography technology	Ge NL (1998)	1
CDH1	4	YWHAE	0	bioid	Guo Z (2014)	1
EXOC3	2	TRIP11	5	affinity chromatography technology	Huttlin EL (2017)	1
BACH1	3	TRIP11	5	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	USO1	1	bioid	Guo Z (2014)	1
ASB7	1	TRIP11	5	affinity chromatography technology	Huttlin EL (2017)	1
HOOK1	0	TRIP11	5	affinity chromatography technology	Boldt K (2016)	1
CHPF	1	TRIP11	5	affinity chromatography technology	Boldt K (2016)	1
TRIP11	5	PSMC5	4	two hybrid	Choi HS (1996)	1
PSMC5	4	MED4	2	affinity chromatography technology	Huttlin EL (2017)	1