PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIP10	1	WASL	2	pull down, biochemical	Tsujita K (2006), Wan C (2015)	2
WASL	2	WASF1	10	biochemical	Wan C (2015)	1
TRIP10	1	INTS9	1	biochemical	Kristensen AR (2012)	1
POT1	2	SH3BP1	0	two hybrid	Lee OH (2011)	1
BAG6	2	TRIP10	1	affinity chromatography technology	Hein MY (2015)	1
TRIP10	1	WAS	0	two hybrid, pull down, affinity chromatography technology, two hybrid	Tian L (2000), Tian L (2000), Tian L (2000), Yu H (2011)	4
SMARCE1	1	TRIP10	1	two hybrid	Rolland T (2014)	1
ARHGAP17	1	SH3BP1	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIP10	1	SF3A1	1	biochemical	Wan C (2015)	1
SIGLEC5	2	TRIP10	1	affinity chromatography technology	Huttlin EL (2017)	1
WDR44	0	OSBPL11	0	biochemical	Kristensen AR (2012)	1
AP1B1	6	TBC1D2	2	biochemical	Kristensen AR (2012)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
ZDHHC17	1	TRIP10	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
POLD1	5	TBC1D2	2	biochemical	Kristensen AR (2012)	1
BAG6	2	TSEN2	5	affinity chromatography technology	Hein MY (2015)	1
TRIP10	1	STAT3	0	affinity chromatography technology, pull down	Chung YH (2004), Chung YH (2004)	2
CYFIP1	2	TRIP10	1	biochemical	Wan C (2015)	1
TRIP10	1	WBP11	0	two hybrid	Rual JF (2005)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
NPLOC4	4	TRIP10	1	affinity chromatography technology	Raman M (2015)	1
TRIP10	1	UPF2	2	biochemical	Wan C (2015)	1
25885	0	TRIP10	1	biochemical	Wan C (2015)	1
MCM4	3	TRIP10	1	biochemical	Wan C (2015)	1
RHOJ	0	WAS	0	two hybrid	Vignal E (2000)	1
TRIP10	1	POLD1	5	biochemical	Kristensen AR (2012)	1
WASF1	10	PRKACA	2	affinity chromatography technology	Westphal RS (2000)	1
AP1G1	8	OSBPL11	0	biochemical	Kristensen AR (2012)	1
AP1B1	6	TRIP10	1	biochemical	Kristensen AR (2012)	1
RHOQ	0	TRIP10	1	two hybrid, affinity chromatography technology, pull down	Chang L (2002), Chang L (2002), Chang L (2002)	3
SMURF1	4	HNRNPU	12	affinity chromatography technology	Xie Y (2013)	1
TRIP10	1	COPB2	3	biochemical	Wan C (2015)	1
COPE	2	COPA	6	two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Stelzl U (2005), Eugster A (2000), Faulstich D (1996), Harter C (1998), Pavel J (1998), Pavel J (1998), Havugimana PC (2012), Wan C (2015)	8
MCM4	3	SF3A1	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Boldt K (2016)	3
TERF1	1	TRIP10	1	two hybrid	Lee OH (2011)	1
TINF2	1	TRIP10	1	two hybrid	Lee OH (2011)	1
TRIP10	1	SH3BP1	0	two hybrid	Rolland T (2014)	1
TRIP10	1	COPE	2	biochemical	Wan C (2015)	1
TRIP10	1	COPA	6	biochemical	Wan C (2015)	1
TRIP10	1	ARHGAP12	2	two hybrid	Rolland T (2014)	1
POLD1	5	UPF2	2	affinity chromatography technology	Azzalin CM (2006)	1
ARHGAP44	5	ARHGAP17	1	affinity chromatography technology	Huttlin EL (2017)	1
ABL2	4	TRIP10	1	two hybrid	DeGrado-Warren J (2008)	1
HNRNPU	12	SF3A1	1	biochemical	Havugimana PC (2012)	1
90378	0	TRIP10	1	affinity chromatography technology	Hein MY (2015)	1
SMURF1	4	SF3A1	1	affinity chromatography technology	Xie Y (2013)	1
AP1B1	6	INTS9	1	biochemical	Kristensen AR (2012)	1
TSEN2	5	POLD1	5	biochemical	Kristensen AR (2012)	1
CYFIP1	2	WASF1	10	biochemical	Wan C (2015)	1
ARHGAP44	5	CDC42	3	enzymatic study	Richnau N (2001)	1
TRIP10	1	TRIP10	1	two hybrid	Rolland T (2014)	1
POT1	2	TRIP10	1	two hybrid	Lee OH (2011)	1
AP1B1	6	AP1G1	8	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Takatsu H (1998), Foelsch H (1999), Page LJ (1995), Havugimana PC (2012), Hirst J (2000), Wan C (2015)	6
WASL	2	RHOQ	0	pull down, two hybrid	Abe T (2003), Abe T (2003)	2
WASL	2	CDC42	3	pull down, pull down, two hybrid, pull down	Carlier MF (2000), Miki H (1998), Bandyopadhyay S (2010), Martinez-Quiles N (2001)	4
TERF1	1	CYFIP1	2	affinity chromatography technology	Giannone RJ (2010)	1
PRKACA	2	AKAP9	13	affinity chromatography technology	Varjosalo M (2013)	1
TRIP10	1	WDR44	0	biochemical	Kristensen AR (2012)	1
COPB2	3	COPA	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Eugster A (2000), Harter C (1998), Pavel J (1998), Pavel J (1998), Wegmann D (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	8
COPB2	3	COPE	2	two hybrid, affinity chromatography technology, biochemical	Eugster A (2000), Pavel J (1998), Havugimana PC (2012)	3
TRIP10	1	RHOJ	0	two hybrid	Rolland T (2014)	1
TSEN2	5	TBC1D2	2	biochemical	Kristensen AR (2012)	1
TBC1D2	2	INTS9	1	biochemical	Kristensen AR (2012)	1
AKAP9	13	TRIP10	1	two hybrid, pull down	Larocca MC (2004), Larocca MC (2004)	2
HTT	14	ZDHHC17	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid	Faber PW (1998), Singaraja RR (2002), Singaraja RR (2002), Singaraja RR (2002), Suter B (2013), Butland SL (2014)	6
HNRNPU	12	90378	0	affinity chromatography technology	Hein MY (2015)	1
PRKACA	2	TRIP10	1	enzymatic study	Larocca MC (2004)	1
TRIP10	1	TBC1D2	2	biochemical	Kristensen AR (2012)	1
ZDHHC17	1	INPP5D	2	two hybrid	Butland SL (2014)	1
TRIP10	1	CDC42	3	two hybrid, pull down, pull down	Aspenstroem P (1997), Tian L (2000), Aspenstroem P (1997)	3
TRIP10	1	SBK1	0	affinity chromatography technology	Linkermann A (2009)	1
TRIP10	1	OSBPL11	0	biochemical	Kristensen AR (2012)	1
TRIP10	1	ARHGAP44	5	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
POLD1	5	WDR44	0	biochemical	Kristensen AR (2012)	1
CDC42	3	WAS	0	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Tian L (2000), Kim AS (2000), Kolluri R (1996), Symons M (1996), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Edlund S (2004), Tetley GJN (2017)	9
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
TRIP10	1	HNRNPU	12	biochemical	Wan C (2015)	1
TRIP10	1	ARHGAP17	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Richnau N (2001), Richnau N (2001), Richnau N (2001), Rolland T (2014)	4
ARHGAP17	1	CDC42	3	enzymatic study	Richnau N (2001)	1
TRIP10	1	HTT	14	two hybrid, pull down	Holbert S (2003), Holbert S (2003)	2
FAM189B	2	NPLOC4	4	affinity chromatography technology	Huttlin EL (2017)	1
STAT3	0	ABL2	4	two hybrid	Grossmann A (2015)	1
WASL	2	RHOJ	0	two hybrid	Rolland T (2014)	1
TRIP10	1	DNM2	2	affinity chromatography technology, pull down	Linkermann A (2009), Tsujita K (2006)	2
TRIP10	1	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
TSEN2	5	TRIP10	1	biochemical	Kristensen AR (2012)	1
TRIP10	1	INPP5D	2	affinity chromatography technology	Linkermann A (2009)	1
WASF1	10	TRIP10	1	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
AP1G1	8	TRIP10	1	biochemical	Kristensen AR (2012)	1
FAM189B	2	TRIP10	1	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	TRIP10	1	enzymatic study	Andrews PS (2010)	1
TERF1	1	SH3BP1	0	two hybrid	Lee OH (2011)	1
ARHGAP44	5	SH3BP1	0	affinity chromatography technology	Huttlin EL (2017)	1
LRRC31	4	TRIP10	1	affinity chromatography technology	Huttlin EL (2017)	1