PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INPP5D	2	LYN	2	affinity chromatography technology, pull down	Baran CP (2003), Baran CP (2003)	2
GRB2	2	AP2M1	5	affinity chromatography technology	Blagoev B (2003)	1
GRB2	2	CD22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000), Otipoby KL (2001)	3
SYK	3	INPP5D	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012), de Castro RO (2012)	3
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
LYN	2	PTPN6	0	pull down	Yoshida K (1999)	1
AP2M1	5	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CD22	3	SYK	3	affinity chromatography technology	Law CL (1996)	1
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
CD22	3	AP2A1	1	affinity chromatography technology	John B (2003)	1
AP2M1	5	CD22	3	two hybrid	John B (2003)	1
SHC1	0	CD22	3	affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000)	2
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
GRB2	2	AP2A1	1	affinity chromatography technology	Blagoev B (2003)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
PTPRC	1	LYN	2	affinity chromatography technology, pull down	Brown VK (1994), Brown VK (1994)	2
INPP5D	2	CD22	3	affinity chromatography technology, affinity chromatography technology	Poe JC (2000), Poe JC (2000)	2
CD19	3	CD22	3	affinity chromatography technology	Carter RH (1997)	1
CD22	3	CPA4	2	affinity chromatography technology	Huttlin EL (2017)	1
SHC1	0	PLCG1	6	affinity chromatography technology	Fixman ED (1996)	1
CD22	3	S100A7	1	affinity chromatography technology	Huttlin EL (2017)	1
PTPN6	0	SYK	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ganju RK (2000), Dustin LB (1999), Dustin LB (1999)	3
CD22	3	PTPN6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blasioli J (1999), Blasioli J (1999), Otipoby KL (2001), Greer SF (1999), Law CL (1996), Adachi T (2001)	6
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
INPP5D	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002)	9
CD22	3	PLCG1	6	affinity chromatography technology	Law CL (1996)	1
CD19	3	SYK	3	affinity chromatography technology	Carter RH (1997)	1
LYN	2	CD22	3	enzymatic study, affinity chromatography technology	Poe JC (2000), Greer SF (1999)	2
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
SHC1	0	AP2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2017)	3
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
SHC1	0	S100A7	1	affinity chromatography technology	Brehme M (2009)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
CD22	3	PTPRC	1	affinity chromatography technology	Greer SF (1999)	1
PLCG1	6	SYK	3	affinity chromatography technology	Sidorenko SP (1995)	1