PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCEAL1	3	PDCD5	0	affinity chromatography technology	Sowa ME (2009)	1
TRIM25	5	UROS	0	biochemical, affinity chromatography technology	Wan C (2015), Choudhury NR (2017)	2
TCEAL1	3	HOXB9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	MAPK14	0	affinity chromatography technology	Choudhury NR (2017)	1
ZUFSP	0	USP11	3	affinity chromatography technology	Hermanns T (2018)	1
MAPK14	0	PTPN11	20	biochemical	Kristensen AR (2012)	1
IFT43	0	USP11	3	affinity chromatography technology	Huttlin EL (2017)	1
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
TCEAL1	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GMPS	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Reddy BA (2014), Reddy BA (2014)	2
PPP2R2A	0	HSPA4L	1	biochemical	Kristensen AR (2012)	1
TCEAL1	3	TCEAL4	0	affinity chromatography technology	Sowa ME (2009)	1
DYRK1B	1	TCEAL1	3	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	TCEAL1	3	affinity chromatography technology	Varjosalo M (2013)	1
TCEAL1	3	DTL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	HSPA4L	1	affinity chromatography technology	Ewing RM (2007)	1
TCEAL1	3	CDCA2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	TIPIN	1	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	UHRF1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Felle M (2011), Felle M (2011), Felle M (2011), Felle M (2011), Qin W (2011), Qin W (2011), Ma H (2012), Ma H (2012), Ma H (2012), Chen H (2013), Nishiyama A (2013), Hein MY (2015), Zhang ZM (2015), Zhang ZM (2015), Zhang ZM (2015), Pfoh R (2015), Pfoh R (2015), Ferry L (2017)	18
TCEAL1	3	FEM1A	2	affinity chromatography technology	Sowa ME (2009)	1
FAF1	1	CUL2	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
MAPK6	1	TCEAL1	3	affinity chromatography technology	Rodriguez J (2016)	1
USP11	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Maertens GN (2010), Maertens GN (2010), Ma H (2012), Hein MY (2015)	7
UBE2Q1	0	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Shafiee SM (2015), Shafiee SM (2015), Shafiee SM (2015)	3
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
UHRF1	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study	Ma J (2015), Ma J (2015), Ma J (2015), Ma J (2015)	4
TCEAL4	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hein MY (2015), Hein MY (2015)	3
PPP2R2A	0	55844	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Huttlin EL (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	5
MAPK14	0	DYRK1B	1	enzymatic study	Lee K (2000)	1
PDCD5	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Xu L (2012), Xu L (2012), Xu L (2012), Xu L (2012), Park SY (2015)	5
TCEAL1	3	PPP2R2A	0	affinity chromatography technology	Ewing RM (2007)	1
TCEAL1	3	GMPS	1	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	TCEAL1	3	affinity chromatography technology	Huttlin EL (2015)	1
TCEAL1	3	TDP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
UROS	0	TCEAL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	55844	0	affinity chromatography technology	Sowa ME (2009)	1
TCEAL1	3	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
TCEAL1	3	C9orf40	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	HOXB6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	UHRF1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
CUL2	3	FEM1C	2	affinity chromatography technology	Bennett EJ (2010)	1
TCEAL1	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
WDR4	4	TCEAL1	3	affinity chromatography technology	Huttlin EL (2017)	1
TCEAL1	3	SASS6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	MAPK6	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
EGLN3	0	SSR3	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	HSPA4L	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
TCEAL1	3	MCMBP	3	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	ZNF703	0	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
UBC	7	TCEAL1	3	pull down	Zhang X (2017)	1
UBC	7	ELOC	0	pull down	Zhang X (2017)	1
TCEAL1	3	CHEK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAF1	1	USP11	3	affinity chromatography technology	Raman M (2015)	1
MAPK6	1	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	STAT3	0	affinity chromatography technology	Choudhury NR (2017)	1
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	USP11	3	affinity chromatography technology	Choudhury NR (2017)	1
MAPK6	1	TDP2	2	two hybrid	Vinayagam A (2011)	1
USP7	14	MCMBP	3	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, pull down	Sowa ME (2009), Jagannathan M (2014), Jagannathan M (2014), Jagannathan M (2014), Jagannathan M (2014)	5
EGLN3	0	HOXB9	0	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL1	3	EYA3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
PHF7	5	TCEAL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP7	14	GMPS	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van der Knaap JA (2005), van der Knaap JA (2005), van der Knaap JA (2005), Sowa ME (2009), Sarkari F (2009), Wan C (2015), Hein MY (2015), Pfoh R (2015), Pfoh R (2015), Reddy BA (2014), Reddy BA (2014)	11
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
IFT43	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	FEM1A	2	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
CHEK1	2	USP11	3	genetic interference	Srivas R (2016)	1
ZUFSP	0	UBC	7	enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Hermanns T (2018), Hermanns T (2018), Hermanns T (2018), Kwasna D (2018), Kwasna D (2018), Kwasna D (2018), Haahr P (2018), Haahr P (2018), Haahr P (2018)	9
MAPK14	0	HOXB9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	EYA3	0	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL1	3	USP4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	PPP2R2A	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
TCEAL1	3	SSR3	0	affinity chromatography technology	Ewing RM (2007)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
SASS6	1	HAUS7	0	bioid	Gupta GD (2015)	1
EGLN3	0	ELOC	0	affinity chromatography technology	Rodriguez J (2016)	1
IFT43	0	TCEAL1	3	affinity chromatography technology	Huttlin EL (2017)	1
UHRF1	3	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2012), Ma H (2012), Ma H (2012)	3
TCEAL1	3	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
TCEAL1	3	CUL2	3	affinity chromatography technology	Sowa ME (2009)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
TCEAL1	3	ZKSCAN4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	WDR4	4	affinity chromatography technology	Choudhury NR (2017)	1
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
CHEK1	2	DTL	0	affinity chromatography technology, enzymatic study, enzymatic study	Huh J (2013), Cheng YC (2013), Huh J (2013)	3
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
TCEAL1	3	ZNF503	0	affinity chromatography technology	Huttlin EL (2015)	1
MAPK14	0	USP11	3	affinity chromatography technology	Varjosalo M (2013)	1
TRIM25	5	EYA3	0	affinity chromatography technology	Choudhury NR (2017)	1
HOXB6	0	TCEAL1	3	two hybrid	Ravasi T (2010)	1
DTL	0	TP53	0	affinity chromatography technology, enzymatic study	Banks D (2006), Banks D (2006)	2
USP11	3	USP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Zhang L (2012)	3
EGLN3	0	TCEAL1	3	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL1	3	FEM1C	2	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	CHEK1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Qing P (2011), Zhang P (2014), Zhang P (2014), Tan X (2015), Alonso-de Vega I (2014)	5
TCEAL1	3	ELOC	0	affinity chromatography technology	Sowa ME (2009)	1
WDR4	4	PPP2R2A	0	biochemical	Wan C (2015)	1
CUL2	3	FEM1A	2	affinity chromatography technology	Bennett EJ (2010)	1
TCEAL1	3	ZNF703	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	UBE2Q1	0	affinity chromatography technology	Rodriguez J (2016)	1
DYRK1B	1	USP11	3	affinity chromatography technology	Varjosalo M (2013)	1
TCEAL1	3	UBE2Q1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	SSR3	0	affinity chromatography technology	Choudhury NR (2017)	1
USP11	3	UBE2Q1	0	affinity chromatography technology	Hein MY (2015)	1
SCNM1	0	TCEAL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	FAF1	1	affinity chromatography technology	Choudhury NR (2017)	1
TCEAL1	3	ZUFSP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hermanns T (2018)	3
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
TCEAL1	3	STAT3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHF7	5	USP7	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCEAL1	3	POGK	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
TCEAL1	3	KDM3A	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
EGLN3	0	GMPS	1	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
EGLN3	0	TCEAL4	0	affinity chromatography technology	Rodriguez J (2016)	1
TRUB1	2	TCEAL1	3	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	USP11	3	affinity chromatography technology	Rodriguez J (2016)	1
STAT3	0	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Gunaje JJ (2001), M L (2016)	2
MAPK6	1	HSPA4L	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HAUS7	0	affinity chromatography technology	Rodriguez J (2016)	1
USP11	3	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
TCEAL4	0	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
HAUS7	0	TCEAL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRUB1	2	USP11	3	affinity chromatography technology	Huttlin EL (2017)	1
TCEAL4	0	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Hein MY (2015), Hein MY (2015)	5
EGLN3	0	MCMBP	3	affinity chromatography technology	Rodriguez J (2016)	1