PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIBF1	2	PTPRQ	5	affinity chromatography technology	Boldt K (2016)	1
CTNNB1	30	EZR	8	affinity chromatography technology	Hiscox S (1999)	1
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
PODXL	3	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Meder D (2005), Takeda T (2001), Takeda T (2001), Li Y (2002), Li Y (2002)	5
PRKD1	7	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
SMARCA2	17	SIN3A	13	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sif S (2001), Sif S (2001), Pal S (2003), Pal S (2003), Nakamura T (2002), Nakamura T (2002), Kemper JK (2004), Kemper JK (2004), Wan C (2015)	9
SLC9A3R2	8	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
SLC9A3R2	8	LSM12	0	biochemical	Wan C (2015)	1
CFTR	5	SLC9A3R2	8	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sun F (2000), Sun F (2000), Wang X (2006), Pankow S (2015)	4
CFTR	5	EZR	8	affinity chromatography technology, affinity chromatography technology	Sun F (2000), Pankow S (2015)	2
SLC9A3R2	8	PTPRQ	5	affinity chromatography technology	Boldt K (2016)	1
SLC9A3R2	8	NPC2	0	biochemical	Havugimana PC (2012)	1
ACTN1	5	CTNNA1	7	affinity chromatography technology, imaging technique	Knudsen KA (1995), Chen TC (2014)	2
LGALS9	0	CTNNB1	30	affinity chromatography technology	Ewing RM (2007)	1
SLC9A3R2	8	SEPT11	2	biochemical	Havugimana PC (2012)	1
EZR	8	SLC9A3R2	8	pull down, affinity chromatography technology	Yun CH (1998), Sitaraman SV (2002)	2
COPS8	2	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
ADRB2	0	SLC9A3R2	8	pull down, affinity chromatography technology	Hall RA (1998), Roy SJ (2013)	2
PDPK1	0	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Chun J (2002), Chun J (2002)	2
PLCB3	1	SLC9A3R2	8	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Hwang JI (2000), Hwang JI (2000), Hwang JI (2000), Hwang JI (2000)	4
ACTN1	5	ACTN4	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CDH1	4	ATXN2L	4	bioid	Guo Z (2014)	1
SLC9A3R2	8	SMARCA2	17	biochemical	Havugimana PC (2012)	1
ARHGEF6	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
KCTD5	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
SLC9A3R2	8	ACTN4	4	affinity chromatography technology, pull down, affinity chromatography technology	Kim JH (2002), Kim JH (2002), Boldt K (2016)	3
SLC9A3R2	8	ANXA11	0	biochemical	Wan C (2015)	1
CFTR	5	CDH1	4	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
CFTR	5	KIF3A	4	affinity chromatography technology	Wang X (2006)	1
PHLPP1	4	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), St-Denis N (2016)	2
SLC9A3R2	8	ABCC4	3	pull down	Li C (2007)	1
CFTR	5	ACTN4	4	affinity chromatography technology	Pankow S (2015)	1
PDZK1	0	KCTD5	0	affinity chromatography technology	Huttlin EL (2017)	1
SGK1	4	HRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
USH1C	2	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	PLCB3	1	bioid	Guo Z (2014)	1
SEPT11	2	TST	0	biochemical	Havugimana PC (2012)	1
SLC9A3R2	8	SGK1	4	pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Chun J (2002), Chun J (2002), Chun J (2002), Yun CC (2002), Yun CC (2002)	5
EZR	8	PRKCA	7	affinity chromatography technology	Ng T (2001)	1
ANXA11	0	NDUFV1	1	biochemical	Wan C (2015)	1
SMAD3	1	SLC9A3R2	8	affinity chromatography technology	Brown KA (2008)	1
CDH1	4	RPL29	0	bioid	Guo Z (2014)	1
ADRB2	0	NDUFV1	1	affinity chromatography technology	Roy SJ (2013)	1
LPAR2	0	PLCB3	1	pull down, affinity chromatography technology	Oh YS (2004), Oh YS (2004)	2
SLC9A3R2	8	ADORA2B	0	affinity chromatography technology	Sitaraman SV (2002)	1
SLC9A3R2	8	ATXN2L	4	biochemical	Wan C (2015)	1
SLC9A3R2	8	HRAS	2	biochemical	Havugimana PC (2012)	1
TUSC3	1	SLC9A3R2	8	affinity chromatography technology	Huttlin EL (2017)	1
LGALS9	0	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	CTNNA1	7	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	ATXN2L	4	affinity chromatography technology	Wang X (2006)	1
SLC9A3R2	8	RTN4	4	biochemical	Havugimana PC (2012)	1
SEPT11	2	SMARCA2	17	biochemical	Havugimana PC (2012)	1
SLC9A3R2	8	TOMM40	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
KCNJ1	0	SLC9A3R2	8	two hybrid, pull down	Yoo D (2004), Yoo D (2004)	2
PDZK1	0	ABCC4	3	pull down, affinity chromatography technology	Li C (2007), Huttlin EL (2017)	2
KIFAP3	1	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
TRIP6	2	SLC9A3R2	8	affinity chromatography technology	E S (2009)	1
YAP1	0	ACTN1	5	affinity chromatography technology	Enzo E (2015)	1
PTPRQ	5	AHI1	4	affinity chromatography technology	Boldt K (2016)	1
YAP1	0	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	EZR	8	affinity chromatography technology, bioid	Hiscox S (1999), Guo Z (2014)	2
MRAP2	0	SLC9A3R2	8	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R2	8	CTNNA1	7	affinity chromatography technology	Boldt K (2016)	1
TRIP6	2	KCTD5	0	affinity chromatography technology	Ewing RM (2007)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
SLC9A3R2	8	RPL29	0	biochemical	Havugimana PC (2012)	1
SLC9A3R2	8	TST	0	biochemical	Havugimana PC (2012)	1
TOMM40	1	NDUFV1	1	biochemical	Wan C (2015)	1
KIF3B	3	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
WWTR1	1	SLC9A3R2	8	affinity chromatography technology	Kanai F (2000)	1
CDH1	4	RTN4	4	bioid	Guo Z (2014)	1
SLC9A3R2	8	AHI1	4	affinity chromatography technology	Boldt K (2016)	1
WASF3	3	SLC9A3R2	8	affinity chromatography technology	Huttlin EL (2017)	1
KIF3A	4	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	TRIP6	2	bioid	Guo Z (2014)	1
NUDT5	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
PRKCA	7	CTNNB1	30	affinity chromatography technology	Mertz JA (2011)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
KIF3A	4	KIFAP3	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lolkema MP (2007), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
MRAP2	0	PODXL	3	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R2	8	NUSAP1	0	biochemical	Havugimana PC (2012)	1
GTF2E2	2	SLC9A3R2	8	affinity chromatography technology	Huttlin EL (2017)	1
SLC9A3R2	8	MARS2	0	biochemical	Wan C (2015)	1
PHLPP1	4	PHLPP2	5	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), St-Denis N (2016)	2
TST	0	UBE2M	0	biochemical	Havugimana PC (2012)	1
CFTR	5	SEPT11	2	affinity chromatography technology	Wang X (2006)	1
SLC9A3R2	8	PPT1	1	biochemical	Havugimana PC (2012)	1
CTNNB1	30	COPS8	2	affinity chromatography technology	Huang X (2009)	1
SLC9A3R2	8	LPAR2	0	affinity chromatography technology, affinity chromatography technology, pull down	E S (2009), Oh YS (2004), Oh YS (2004)	3
SLC9A3R2	8	PRKCA	7	pull down	Lee-Kwon W (2003)	1
CDH1	4	YAP1	0	bioid	Guo Z (2014)	1
CFTR	5	CTNNB1	30	affinity chromatography technology	Pankow S (2015)	1
PDZK1	0	SLC9A3	10	two hybrid	Gisler SM (2003)	1
CFTR	5	ABCC4	3	affinity chromatography technology	Li C (2007)	1
PLCB2	0	SLC9A3R2	8	affinity chromatography technology	Hwang JI (2000)	1
SLC9A3R2	8	UBE2M	0	biochemical	Havugimana PC (2012)	1
SLC9A3R2	8	NUDT19	2	biochemical	Havugimana PC (2012)	1
SLC9A3R2	8	SIN3A	13	biochemical	Havugimana PC (2012)	1
NUDT5	0	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
TRIP6	2	LPAR2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Xu J (2004), Xu J (2004), Xu J (2004), E S (2009), E S (2009), Solaz-Fuster MC (2006)	6
TMA16	0	SLC9A3R2	8	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	NUDT5	0	bioid	Guo Z (2014)	1
YAP1	0	TRIP6	2	affinity chromatography technology	Enzo E (2015)	1
PIBF1	2	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
RPS28	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
NPC2	0	NUDT19	2	biochemical	Havugimana PC (2012)	1
SMAD3	1	SIN3A	13	pull down	Liberati NT (2001)	1
CFTR	5	KCNJ1	0	affinity chromatography technology	Yoo D (2004)	1
EZR	8	ADORA2B	0	affinity chromatography technology	Sitaraman SV (2002)	1
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
NUDT5	0	YAP1	0	affinity chromatography technology	Boldt K (2016)	1
PHLPP2	5	EZR	8	affinity chromatography technology	Sowa ME (2009)	1
SLC9A3R2	8	ACTN1	5	affinity chromatography technology	Boldt K (2016)	1
SMAD3	1	ATXN2L	4	affinity chromatography technology	Brown KA (2008)	1
PHLPP2	5	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), St-Denis N (2016)	2
KIF3A	4	KIF3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lolkema MP (2007), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	4
YAP1	0	RTN4	4	affinity chromatography technology	Enzo E (2015)	1
ACTN1	5	EZR	8	biochemical	Havugimana PC (2012)	1
SGK1	4	PDPK1	0	pull down, pull down, enzymatic study	Chun J (2002), Park J (1999), Jung H (2007)	3
PTPRQ	5	EZR	8	affinity chromatography technology	Boldt K (2016)	1
CDH23	9	USH1C	2	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Boeda B (2002), Boeda B (2002), Siemens J (2002), Siemens J (2002), Siemens J (2002)	5
PTH1R	2	SLC9A3R2	8	far western blotting, far western blotting, affinity chromatography technology	Mahon MJ (2002), Mahon MJ (2002), Mahon MJ (2002)	3
SLC9A3R2	8	NDUFV1	1	biochemical	Wan C (2015)	1
ARHGAP44	5	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
ATXN2L	4	LSM12	0	biochemical	Wan C (2015)	1
ACTN4	4	CTNNB1	30	imaging technique	Chen TC (2014)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
PIBF1	2	AHI1	4	affinity chromatography technology	Boldt K (2016)	1
OTUD7B	3	SLC9A3R2	8	affinity chromatography technology	Sowa ME (2009)	1
PRKD1	7	YAP1	0	affinity chromatography technology	Boldt K (2016)	1
SLC26A3	1	SLC9A3R2	8	pull down	Lamprecht G (2002)	1
PDZK1	0	CFTR	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gentzsch M (2003), Gentzsch M (2003), Wang S (2000), Li C (2007)	4
SEPT11	2	SIN3A	13	biochemical	Havugimana PC (2012)	1
PDZK1	0	SLC9A3R2	8	two hybrid	Gisler SM (2003)	1
SEPT11	2	TOMM40	1	biochemical	Havugimana PC (2012)	1
LGALS9	0	PODXL	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC9A3R2	8	TACO1	1	biochemical	Havugimana PC (2012)	1
SIN3A	13	GTF2E2	2	biochemical	Wan C (2015)	1
CDH1	4	SLC9A3R2	8	bioid	Guo Z (2014)	1
CFTR	5	ACTN1	5	affinity chromatography technology	Pankow S (2015)	1
TOMM40	1	ANXA11	0	biochemical	Wan C (2015)	1
KIFAP3	1	KIF3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	3
CDH1	4	ACTN4	4	affinity chromatography technology	Catimel B (2005)	1
YAP1	0	SLC9A3R2	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Boldt K (2016), Enzo E (2015)	3
SLC9A3	10	SLC9A3R2	8	pull down	Yun CH (1998)	1
CDH23	9	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1