PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNMT3L	2	PAX6	3	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
MSX1	0	LHX2	0	pull down	Bendall AJ (1998)	1
DNMT3L	2	LDB1	2	pull down	Pacaud R (2014)	1
LDB1	2	LHX2	0	two hybrid	Ravasi T (2010)	1
LHX2	0	CITED2	0	two hybrid, pull down, affinity chromatography technology	Glenn DJ (1999), Glenn DJ (1999), Glenn DJ (1999)	3
PAX6	3	LHX2	0	pull down	Mikkola I (2001)	1
DNMT3L	2	LHX2	0	pull down	Pacaud R (2014)	1