PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
MCM2	3	CPNE4	2	affinity chromatography technology	Drissi R (2015)	1
PIN1	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
CPNE4	2	CPNE6	1	affinity chromatography technology	Huttlin EL (2017)	1
LAMTOR3	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
TK1	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
SMN1	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
CDKN1A	1	CPNE6	1	two hybrid	Vinayagam A (2011)	1
GRB7	1	CPNE6	1	two hybrid	Vinayagam A (2011)	1
TTR	0	CPNE6	1	two hybrid	Vinayagam A (2011)	1
MEOX2	2	CPNE6	1	two hybrid	Rolland T (2014)	1
MAPK11	1	CPNE6	1	two hybrid	Vinayagam A (2011)	1
CPNE6	1	AK5	2	two hybrid	Stelzl U (2005)	1
NOTCH3	9	CPNE6	1	pull down	Jung JG (2014)	1
MCM2	3	CPNE6	1	affinity chromatography technology	Drissi R (2015)	1
MEOX2	2	PIN1	0	two hybrid	Rolland T (2014)	1