Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ADIPOQ	9370	SPIRONOLACTONE	CHEMBL1393		NCI	17142138
ADIPOQ	9370	FENOFIBRATE	CHEMBL672		NCI	17194889
ADIPOQ	9370	NEVIRAPINE	CHEMBL57		NCI	15305892

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ADIPOQ	rs1063538	CC + CT	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotypes CC + CT are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotype TT.	25405601	1444667028
ADIPOQ	rs2241766	GT	pioglitazone	efficacy	yes	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%). When comparing the response rates between patients with the GT versus TT genotypes, the GT genotypes were associated with a greater frequency of response (52.94% versus 12.7% p=0.001) as well as a greater decrease in HbA1c% as compared to patients with the TT genotype (1.15 versus 0.52 p=0.001). Logistic regression analysis showed that rs2241766 GT genotype was associated with response to pioglitazone. *Please note: there were no individuals of genotype GG.	Genotype GT is associated with increased response to pioglitazone in people with Diabetes Mellitus as compared to genotype TT.	25405601	1444666816
ADIPOQ	rs16861194	AG	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotype AG are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotype AA.	25405601	1444666944
ADIPOQ	rs2082940	CC	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotype CC are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotypes CT + TT.	25405601	1444666966
ADIPOQ	rs266729	CC	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotype CC are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotypes CG + GG.	25405601	1444666932
ADIPOQ	rs1063537	CC	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotype CC are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotypes CT + TT.	25405601	1444666960
ADIPOQ	rs1501299	GT + TT	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotypes GT + TT are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotype TT.	25405601	1444666874
ADIPOQ	rs3821799	CT + TT	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%). The TT genotype was associated with a greater decrease in waist circumference as compared to the TC and CC genotypes after pioglitazone therapy (p=0.033).	Genotypes CT + TT are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotype CC.	25405601	1444666920
ADIPOQ	rs2241767	AA	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%).	Genotype AA are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotypes AG + GG.	25405601	1444666909
ADIPOQ	rs3774261	AG + GG	pioglitazone	efficacy	no	Response was defined as "any decrease greater than (or equal to) 15%" of glycated hemoglobin (HbA1C%). The AA genotype was associated with a greater decrease in waist circumference as compared to the AG and GG genotypes after pioglitazone therapy (p=0.019) although the AG and GG genotypes were associated with a greater decrease in fasting insulin as compared to the AA genotype (p=0.03).	Genotypes AG + GG are not associated with response to pioglitazone in people with Diabetes Mellitus as compared to genotype AA.	25405601	1444666926