PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZFYVE9	5	PPP1CC	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Colland F (2004), Rolland T (2014), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	5
CTNNB1	30	PPARG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zurlo D (2014), Zurlo D (2014), Jansson EA (2005), Jiang Y (2009)	4
EGLN3	0	FHL2	0	affinity chromatography technology	Rodriguez J (2016)	1
ZFYVE9	5	RBBP6	7	two hybrid	Colland F (2004)	1
PPP1CA	3	CLTC	12	two hybrid	Esteves SL (2012)	1
ZFYVE9	5	ERBIN	5	two hybrid	Colland F (2004)	1
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
PPP1CA	3	ERBIN	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
PPARG	0	SMAD3	1	affinity chromatography technology	Lin LC (2011)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
ZFYVE9	5	BAG6	2	two hybrid	Colland F (2004)	1
CLTC	12	PPP2R1A	8	biochemical	Wan C (2015)	1
CLTC	12	ERBIN	5	affinity chromatography technology	Hein MY (2015)	1
SMAD2	5	ZFYVE9	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Faresse N (2008), Miura S (2000), Seo SR (2006), Brown KA (2008), Colland F (2004), Lu D (2013)	9
ZFYVE9	5	SUMF2	0	two hybrid	Colland F (2004)	1
UBC	7	FHL2	0	affinity chromatography technology	Matsumoto M (2005)	1
EGLN3	0	PPP1CA	3	affinity chromatography technology	Rodriguez J (2016)	1
ZFYVE9	5	BMP4	0	two hybrid	Colland F (2004)	1
ZFYVE9	5	TSG101	1	affinity chromatography technology, affinity chromatography technology	Kostaras E (2012), Kostaras E (2012)	2
SPART	0	CLTC	12	affinity chromatography technology	Milewska M (2009)	1
ZFYVE9	5	SPART	0	two hybrid	Colland F (2004)	1
PPP1CC	2	ERBIN	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
SMAD3	1	SVEP1	10	two hybrid	Colland F (2004)	1
RNF11	0	ZFYVE9	5	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, two hybrid	Kostaras E (2012), Kostaras E (2012), Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2014), Kostaras E (2012)	7
UBC	7	ZFYVE9	5	pull down	Kostaras E (2012)	1
ZFYVE9	5	STAM2	0	affinity chromatography technology	Kostaras E (2012)	1
ZFYVE9	5	SUPT5H	2	two hybrid	Colland F (2004)	1
PPARG	0	SMAD2	5	affinity chromatography technology	Lu D (2013)	1
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
PPP1R3A	2	ERBIN	5	affinity chromatography technology	Hauri S (2013)	1
EGLN3	0	ANKLE2	5	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	ERBIN	5	affinity chromatography technology	Rodriguez J (2016)	1
HERC2	9	CTNNB1	30	affinity chromatography technology	Galligan JT (2015)	1
ZFYVE9	5	NUP155	2	two hybrid	Colland F (2004)	1
EGLN3	0	ZFYVE9	5	affinity chromatography technology	Rodriguez J (2016)	1
ZFYVE9	5	PPP2R1A	8	two hybrid	Colland F (2004)	1
DAZAP2	1	CTNNB1	30	affinity chromatography technology	Lukas J (2009)	1
ZFYVE9	5	ETS2	1	two hybrid	Colland F (2004)	1
PPP1R3A	2	ZFYVE9	5	affinity chromatography technology	Hauri S (2013)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
SMAD2	5	PPP2R1A	8	two hybrid	Colland F (2004)	1
ZFYVE9	5	NIT1	1	two hybrid	Colland F (2004)	1
ERBIN	5	CTNNB1	30	unspecified method	Boisguerin P (2004)	1
ZFYVE9	5	DAZAP2	1	two hybrid	Colland F (2004)	1
PML	7	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology	Satow R (2012), Satow R (2012), Shtutman M (2002)	3
EGLN3	0	PML	7	affinity chromatography technology	Rodriguez J (2016)	1
FAM46A	2	BAG6	2	two hybrid	Colland F (2004)	1
PML	7	ZFYVE9	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2004), Lin HK (2004), Seo SR (2006)	3
PPP1R3A	2	PPP1CB	9	affinity chromatography technology	Hauri S (2013)	1
ZFYVE9	5	ZMYND8	5	two hybrid	Colland F (2004)	1
PPP1R3A	2	PPP1CA	3	affinity chromatography technology	Hauri S (2013)	1
NCKIPSD	2	ZFYVE9	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	PPP2R1A	8	affinity chromatography technology	Rodriguez J (2016)	1
SMAD3	1	ZFYVE9	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Lin HK (2004), Tsukazaki T (1998), Tsukazaki T (1998), Brown KA (2008), Colland F (2004), Qin BY (2002), Qin BY (2002), Huttlin EL (2015), Huttlin EL (2017)	9
ZFYVE9	5	PPARG	0	affinity chromatography technology	Lu D (2013)	1
CLTC	12	ZFYVE9	5	pull down	Kostaras E (2012)	1
ZFYVE9	5	FHL2	0	two hybrid	Colland F (2004)	1
TSG101	1	BAG6	2	affinity chromatography technology	Schlundt A (2009)	1
ZFYVE9	5	PPP1CB	9	two hybrid	Colland F (2004)	1
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
DEFA6	0	ZFYVE9	5	affinity chromatography technology	Huttlin EL (2017)	1
FHL2	0	JUP	7	two hybrid	Rolland T (2014)	1
SCYL2	2	CLTC	12	affinity chromatography technology	So J (2015)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
PPP2R1A	8	ANKLE2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Fogeron ML (2013), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	6
ZFYVE9	5	RHOT2	1	two hybrid	Colland F (2004)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBC	7	PPP2R1A	8	affinity chromatography technology	Matsumoto M (2005)	1
PPP1CC	2	CLTC	12	two hybrid	Esteves SL (2012)	1
SMAD2	5	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
EGLN3	0	BAG6	2	affinity chromatography technology	Rodriguez J (2016)	1
HERC2	9	ZFYVE9	5	affinity chromatography technology, affinity chromatography technology	Galligan JT (2015), Galligan JT (2015)	2
SMAD2	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Xi Y (2013)	3
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
DAZAP2	1	STAM2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZFYVE9	5	SCYL2	2	two hybrid	Colland F (2004)	1
PML	7	PPARG	0	two hybrid	Ravasi T (2010)	1
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
ZFYVE9	5	CTNNB1	30	two hybrid	Colland F (2004)	1
RHOT2	1	UBC	7	affinity chromatography technology	Huttlin EL (2017)	1
ZFYVE9	5	FAM46A	2	two hybrid	Colland F (2004)	1
FHL2	0	SMAD2	5	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
ZFYVE9	5	SVEP1	10	two hybrid	Colland F (2004)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
ZFYVE9	5	JUP	7	two hybrid	Colland F (2004)	1
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
ZFYVE9	5	UBXN11	1	two hybrid	Colland F (2004)	1
PPP1CA	3	ZFYVE9	5	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Esteves SL (2012), Colland F (2004), Colland F (2004), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	6
EGLN3	0	RHOT2	1	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	PPP1CB	9	affinity chromatography technology	Matsumoto M (2005)	1
STAM2	0	TSG101	1	biochemical	Wan C (2015)	1
UBC	7	SPART	0	affinity chromatography technology	Matsumoto M (2005)	1
RNF11	0	STAM2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2012)	4
SMAD3	1	ERBIN	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warner DR (2003), Xi Q (2008), Brown KA (2008), Dai F (2007), Dai F (2007), Dai F (2007)	6
HERC2	9	EIF4G1	9	affinity chromatography technology	Galligan JT (2015)	1
EGLN3	0	TSG101	1	affinity chromatography technology	Rodriguez J (2016)	1
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
SMAD3	1	PPP2R1A	8	two hybrid	Colland F (2004)	1
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ZFYVE9	5	ANKLE2	5	two hybrid	Colland F (2004)	1
ZFYVE9	5	RNPEP	0	two hybrid	Colland F (2004)	1
ZFYVE9	5	EIF4G1	9	two hybrid	Colland F (2004)	1
ZFYVE9	5	CHD6	6	two hybrid	Colland F (2004)	1
EGLN3	0	PPP1CC	2	affinity chromatography technology	Rodriguez J (2016)	1
ST7	2	ZFYVE9	5	affinity chromatography technology, two hybrid	Battle MA (2003), Battle MA (2003)	2
CTNNB1	30	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Wei Y (2003), Wei Y (2003), Wei Y (2003), Wei Y (2003)	4