PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TGFBR1	2	BAMBI	3	pull down, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
ACVRL1	1	PEG10	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005), Lux A (2005)	5
TGFB1	2	FKBP1A	0	two hybrid, two hybrid	Cheng SY (2002), Li Y (2013)	2
ACVRL1	1	PDXDC2P-NPIPB14P	0	affinity chromatography technology	Huttlin EL (2017)	1
FKBP1A	0	ACVR1	4	affinity chromatography technology	Chaikuad A (2012)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
ENG	5	TGFB1	2	affinity chromatography technology	Cheifetz S (1992)	1
SNX6	1	ACVRL1	1	affinity chromatography technology	Parks WT (2001)	1
ACVRL1	1	SMAD1	0	enzymatic study	Lee NY (2009)	1
TGFBR1	2	TSC22D1	1	two hybrid, affinity chromatography technology, pull down	Yan X (2011), Yan X (2011), Yan X (2011)	3
ACVR1	4	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
ACVRL1	1	TGFB1	2	affinity chromatography technology, affinity chromatography technology	Oh SP (2000), Attisano L (1993)	2
SNX6	1	TGFBR1	2	affinity chromatography technology	Parks WT (2001)	1
IGSF1	3	INHBA	1	imaging technique	Chapman SC (2001)	1
TGFBR1	2	TGFB1	2	affinity chromatography technology, affinity chromatography technology, pull down	Ebner R (1993), Oh SP (2000), Wakahara K (2005)	3
ACVRL1	1	NR1H2	2	two hybrid, pull down, affinity chromatography technology	Mo J (2002), Mo J (2002), Mo J (2002)	3
ACVR1	4	INHBA	1	affinity chromatography technology	Attisano L (1993)	1
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
ACVRL1	1	BAMBI	3	pull down	Yan X (2009)	1
ENG	5	ACVR1	4	affinity chromatography technology	Barbara NP (1999)	1
HSP90AA1	7	TGFBR1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012), Antonov AS (2012)	6
ACVRL1	1	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
ACVRL1	1	FKBP1A	0	two hybrid	Lee NY (2009)	1
KRAS	1	ACVRL1	1	genetic interference	Luo J (2009)	1
TGFBR1	2	ENG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Guerrero-Esteo M (2002), Barbara NP (1999), Blanco FJ (2008), Blanco FJ (2008), Blanco FJ (2005)	7
CSNK2B	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down	Lee NY (2009), Lee NY (2009), Lee NY (2009), Lee NY (2009), Lee NY (2009)	5
ACVR1	4	BAMBI	3	pull down	Yan X (2009)	1
ACVRL1	1	SLC25A24	1	affinity chromatography technology	Huttlin EL (2017)	1
ACVRL1	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Attisano L (1993), Attisano L (1993)	2
ACVRL1	1	HSP90AA1	7	affinity chromatography technology	Antonov AS (2012)	1
ACVR1	4	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP1A	0	TGFBR1	2	two hybrid, two hybrid, affinity chromatography technology	Wang T (1994), Liu F (1995), Wang T (1994)	3
ACVRL1	1	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
ENG	5	ACVRL1	1	affinity chromatography technology, affinity chromatography technology	Blanco FJ (2005), Blanco FJ (2005)	2
PEG10	2	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
ACVRL1	1	INHBA	1	affinity chromatography technology	Attisano L (1993)	1
PEG10	2	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2