Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ORMDL3 rs2872507 AA + AG fluticasone propionate efficacy yes as measured by increase in FEV1. This was significant in the whole group and in atopic asthmatics but not non-atopic asthmatics. (NB: allele frequencies are from table 2 and is from larger numbers of patients than those that had FEV1 phenotypes) Genotypes AA + AG are associated with increased response to fluticasone propionate in children with Asthma as compared to genotype GG. 22986918 981344658