PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STXBP1	38	STX1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Bhaskar K (2004), Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Barclay JW (2003), Ciufo LF (2005)	6
CEP70	1	SYTL4	0	two hybrid	Rolland T (2014)	1
FXR2	2	SYTL4	0	two hybrid	Rolland T (2014)	1
USP20	3	SYTL4	0	affinity chromatography technology	Sowa ME (2009)	1
RAB11A	4	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
TBC1D30	3	MYO5B	13	affinity chromatography technology	Vogel GF (2015)	1
MYO5B	13	RAB11A	4	two hybrid, affinity chromatography technology	Roland JT (2007), Vogel GF (2015)	2
FXR2	2	CCDC85B	0	two hybrid	Rual JF (2005)	1
EVI5	2	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
EVI5	2	MYO5B	13	affinity chromatography technology	Vogel GF (2015)	1
MYO5B	13	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
SYTL4	0	STXBP1	38	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fukuda M (2003), Ciufo LF (2005), van Breevoort D (2014), van Breevoort D (2014)	4
MYO5B	13	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
RAB11A	4	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
RAB8A	0	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
STXBP1	38	STX2	1	affinity chromatography technology, affinity chromatography technology	Schraw TD (2003), van Breevoort D (2014)	2
SYTL4	0	STX2	1	affinity chromatography technology	van Breevoort D (2014)	1
SYTL4	0	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
STXBP1	38	STX3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Breevoort D (2014), van Breevoort D (2014), Huttlin EL (2015), Huttlin EL (2017)	4
RAB11A	4	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
RAB27B	0	SYTL4	0	affinity chromatography technology, pull down, affinity chromatography technology	Zhao S (2002), Zhao S (2002), Huttlin EL (2017)	3
ZBTB7B	6	SYTL4	0	two hybrid	Rolland T (2014)	1
STX3	3	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
RAB8B	0	SYTL4	0	affinity chromatography technology	Huttlin EL (2017)	1
TBC1D30	3	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
RAB8A	0	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
HMG20A	0	SYTL4	0	two hybrid	Rolland T (2014)	1
RAB8B	0	RAB8A	0	affinity chromatography technology	Huttlin EL (2017)	1
SYTL4	0	RAB8A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukuda M (2003), Fukuda M (2002), Fukuda M (2002), Kuroda TS (2002), Kuroda TS (2002), Hampson A (2013), Hampson A (2013), Hampson A (2013), Hampson A (2013), van Breevoort D (2014), Vogel GF (2015), Vogel GF (2015)	12
SYTL4	0	RAB3A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fukuda M (2003), Kuroda TS (2002), Kuroda TS (2002), Yi Z (2002), Huttlin EL (2015), Huttlin EL (2017)	6
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
EVI5	2	STX3	3	affinity chromatography technology, pull down	Vogel GF (2015), Vogel GF (2015)	2
RAB11A	4	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
CCDC85B	0	SYTL4	0	two hybrid	Rual JF (2005)	1
SYTL4	0	STX3	3	affinity chromatography technology, affinity chromatography technology	van Breevoort D (2014), Vogel GF (2015)	2
SYTL4	0	STX1A	2	affinity chromatography technology, affinity chromatography technology, pull down	Fukuda M (2003), Torii S (2002), Torii S (2002)	3
RAB27A	0	SYTL4	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yi Z (2002), Fukuda M (2003), Fukuda M (2003), Fukuda M (2002), Fukuda M (2002), Torii S (2002), Kuroda TS (2002), Kuroda TS (2002), Yi Z (2002), van Breevoort D (2014)	10
MYO5B	13	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
RAB3A	0	RAB3B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYO5B	13	RAB8A	0	two hybrid, affinity chromatography technology	Roland JT (2007), Vogel GF (2015)	2
TBC1D30	3	STX3	3	affinity chromatography technology, pull down	Vogel GF (2015), Vogel GF (2015)	2