PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKACA	2	HAND1	0	enzymatic study	Firulli BA (2003)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
DNMT3L	2	HAND1	0	pull down	Pacaud R (2014)	1
DNMT3L	2	MEF2A	1	pull down	Pacaud R (2014)	1
HAND1	0	SRA1	0	far western blotting	Chooniedass-Kothari S (2010)	1
PRKCA	7	HAND1	0	enzymatic study	Firulli BA (2003)	1
TCF4	26	HAND1	0	affinity chromatography technology	Li X (2015)	1
HAND1	0	TCF3	7	pull down	Morin S (2005)	1
HAND1	0	HEYL	1	pull down	Firulli BA (2000)	1
PPP2R5D	29	HAND1	0	two hybrid	Firulli BA (2003)	1
HAND1	0	HEY2	0	pull down	Firulli BA (2000)	1
MEF2A	1	HAND1	0	affinity chromatography technology, pull down	Morin S (2005), Morin S (2005)	2