PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	CSNK1D	3	pull down	Zemlickova E (2004)	1
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
PPP1R14A	0	CSNK1G2	1	pull down	Zemlickova E (2004)	1
CSNK1G1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CSNK1G3	5	CSNK1G1	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1G1	0	CSNK1G2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSNK1D	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CSNK1G2	1	APP	1	pull down	Olah J (2011)	1
YWHAZ	1	PRKCA	7	affinity chromatography technology	Gannon-Murakami L (2002)	1
YWHAZ	1	PRKCZ	5	pull down, enzymatic study	Zemlickova E (2003), Van Der Hoeven PC (2000)	2
PPP1R14A	0	CSNK1G3	5	pull down	Zemlickova E (2004)	1
PPP1R14A	0	PRKD1	7	pull down, enzymatic study	Zemlickova E (2004), Zemlickova E (2004)	2
PRKCA	7	PRKCH	2	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1G2	1	CSNK1G3	5	affinity chromatography technology	Huttlin EL (2017)	1
PPP1R14A	0	PRKCZ	5	pull down, enzymatic study	Zemlickova E (2004), Zemlickova E (2004)	2
CSNK1A1	1	CSNK1E	0	affinity chromatography technology	Varjosalo M (2013)	1
PPP1R14A	0	PRKCA	7	pull down, enzymatic study	Zemlickova E (2004), Zemlickova E (2004)	2
PRNP	4	PPP1R14A	0	pull down	Satoh J (2009)	1
PPP1R14A	0	PRKCE	6	pull down, enzymatic study	Zemlickova E (2004), Zemlickova E (2004)	2
PPP1R14A	0	CSNK1G1	0	pull down	Zemlickova E (2004)	1
YWHAZ	1	PRKD1	7	pull down	Zemlickova E (2003)	1
PRKCE	6	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Gannon-Murakami L (2002), Gannon-Murakami L (2002)	2
CSNK1A1	1	PPP1R14A	0	biochemical, pull down	Dubois T (2002), Zemlickova E (2004)	2
PPP1R14A	0	APP	1	pull down	Olah J (2011)	1
CSNK1E	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CSNK1A1	1	CSNK1D	3	affinity chromatography technology	Varjosalo M (2013)	1
PPP1R14A	0	PRKCH	2	pull down	Zemlickova E (2004)	1
CSNK1E	0	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
PPP1R14A	0	YWHAZ	1	pull down	Zemlickova E (2004)	1
PPP1R14A	0	CSNK1D	3	pull down	Zemlickova E (2004)	1
PPP1R14A	0	CSNK1E	0	pull down	Zemlickova E (2004)	1