PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SYNC	0	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
SYNC	0	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	PAK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Braverman LE (1999), Cowan CA (2001), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
MED4	2	GIT1	10	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
PKLR	0	ARHGEF6	0	affinity chromatography technology	Brown MC (2002)	1
GIT1	10	GIT2	2	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Kim S (2003), Kim S (2003), Kim S (2003), Huttlin EL (2017)	4
SKP1	0	ARHGEF6	0	affinity chromatography technology	Hauri S (2016)	1
NCK2	2	GIT1	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC42	3	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
ARHGEF6	0	SLC9A3R2	8	affinity chromatography technology	Boldt K (2016)	1
NCK2	2	GIT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	GIT2	2	affinity chromatography technology	So J (2015)	1
PAK2	0	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ARHGEF6	0	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGEF7	3	CBL	7	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Flanders JA (2003), Flanders JA (2003), Schmidt MH (2006), Schmidt MH (2006), Schmidt MH (2006), Wu WJ (2003), Singh VK (2012), Singh VK (2012), Chang CC (2012)	9
CBL	7	SH3GL3	1	affinity chromatography technology	Petrelli A (2002)	1
LPXN	4	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR2	0	CBL	7	pull down, affinity chromatography technology, enzymatic study	Zuo W (2013), Zuo W (2013), Zuo W (2013)	3
ARHGEF6	0	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
NCKIPSD	2	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
GIT2	2	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
LPXN	4	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
NCKIPSD	2	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	PAK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGEF6	0	ZNF580	1	two hybrid	Vinayagam A (2011)	1
RABGGTB	1	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO28	2	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
RABGGTB	1	GIT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK2	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buvall L (2013), Buvall L (2013), Huttlin EL (2015), Huttlin EL (2017)	4
SYNC	0	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
ICAM1	6	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF6	0	GPRASP2	0	two hybrid	Vinayagam A (2011)	1
ARHGEF6	0	SH3GL3	1	two hybrid	Vinayagam A (2011)	1
FBXO28	2	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
NCKIPSD	2	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC42	3	ARHGEF6	0	affinity chromatography technology, imaging technique	Feng Q (2004), Chen TC (2014)	2
PAK2	0	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
ICAM1	6	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	PAK2	0	affinity chromatography technology	Varjosalo M (2013)	1
CDC42	3	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
PAK1	2	TGFBR2	0	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
ICAM1	6	GIT2	2	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	CDC42	3	pull down, pull down, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Morreale A (2000), Wells CD (2006), Marivin A (2013), Varjosalo M (2013), Shen Y (2008), Gonzalez-Martinez D (2004)	11
SYNC	0	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
NCK2	2	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKDC	12	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Maiti AK (2010), Maiti AK (2010)	2
PAK2	0	ARHGEF7	3	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Hein MY (2015)	2
PAK1	2	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
RAC1	7	ARHGEF6	0	affinity chromatography technology, affinity chromatography technology	Sandrock K (2010), Feng Q (2004)	2
NCKIPSD	2	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
ADAM15	2	ARHGEF7	3	pull down	Kaerkkaeinen S (2006)	1
MED4	2	ARHGEF6	0	affinity chromatography technology	Lambert JP (2015)	1
CDC42	3	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wu WJ (2003), Wu WJ (2003), Simmons A (2005)	3
ADAM15	2	ARHGEF6	0	pull down	Kaerkkaeinen S (2006)	1
ICAM1	6	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF6	0	PAK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013), Huttlin EL (2017)	3
PAK2	0	GIT2	2	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
RAC1	7	GIT1	10	affinity chromatography technology	Sandrock K (2010)	1
ARHGEF6	0	ARHGEF6	0	affinity chromatography technology	Feng Q (2004)	1
NCK2	2	NCKIPSD	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
CDC42	3	ARRB2	5	two hybrid	Bandyopadhyay S (2010)	1
PAK2	0	CDC42	3	unspecified method, pull down, pull down, two hybrid, pull down, two hybrid	Stevens WK (1999), Abo A (1998), Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010), Rolland T (2014)	6
PKLR	0	PAK1	2	affinity chromatography technology	Brown MC (2002)	1
GIT2	2	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
ARHGEF6	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
MED4	2	GIT2	2	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
ICAM1	6	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
PAK2	0	GIT1	10	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
ARHGEF6	0	TGFBR2	0	affinity chromatography technology	Barrios-Rodiles M (2005)	1
ARHGEF6	0	TMEM108	1	two hybrid	Vinayagam A (2011)	1
LPXN	4	PAK1	2	affinity chromatography technology	Huttlin EL (2017)	1
GIT1	10	ARHGEF6	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Bagrodia S (1999), Vinayagam A (2011), Huttlin EL (2017)	3
FBXO28	2	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	RAC1	7	pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Katoh H (2003), Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Neri P (2011), Wu Y (2005), Jing J (2009), Qu X (2005), Matos P (2006), Wells CD (2006), Edlund S (2004), Sandrock K (2010), Miki H (2000), Higashi M (2009), Feng H (2015), Gonzalez-Martinez D (2004), Hou Y (2004), Eller-Borges R (2015), Pop M (2004)	19
ARHGEF6	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Kortuem F (2015), Kortuem F (2015)	2
RAC1	7	PAK2	0	pull down, two hybrid, pull down	Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010)	3
LPXN	4	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
CDC42	3	ARHGEF7	3	affinity chromatography technology, pull down	Wu WJ (2003), Wu WJ (2003)	2
ARHGEF6	0	TGFBR1	2	affinity chromatography technology	Barrios-Rodiles M (2005)	1
MED4	2	ARHGEF7	3	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
ARRB2	5	ARHGEF6	0	affinity chromatography technology	Xiao K (2007)	1
MED4	2	ARRB2	5	affinity chromatography technology	Lambert JP (2015)	1
LPXN	4	ARHGEF6	0	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	ARHGEF7	3	affinity chromatography technology	Hauri S (2016)	1
SKP1	0	GIT1	10	affinity chromatography technology	Hauri S (2016)	1
GIT1	10	ARHGEF7	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim S (2003), Kim S (2003), Bagrodia S (1999), Huttlin EL (2017)	4
RABGGTB	1	GIT1	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAK1	2	TGFBR1	2	pull down, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
ARHGEF6	0	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Feng Q (2004), Huttlin EL (2017)	2
ICAM1	6	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
PAK1	2	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ku GM (2001), Schmidt MH (2006), Bandyopadhyay S (2010), Varjosalo M (2013), Huttlin EL (2017)	5
NCKIPSD	2	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
RAC1	7	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Sandrock K (2010), Feng Q (2004)	2
PAK1	2	GIT1	10	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015)	2
LPXN	4	ARHGEF7	3	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	FBXO28	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hauri S (2016), Kratz AS (2016)	3