PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TAF1L	2	TAF6	4	biochemical	Havugimana PC (2012)	1
TP53	0	TBPL1	0	pull down, affinity chromatography technology, affinity chromatography technology	Maeda R (2017), Maeda R (2017), Maeda R (2017)	3
TBPL1	0	PMVK	0	affinity chromatography technology	Ewing RM (2007)	1
TAF4	4	TAF6	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NDUFA6	0	TBPL1	0	two hybrid	Stelzl U (2005)	1
TERF1	1	GTF2A2	0	affinity chromatography technology	Giannone RJ (2010)	1
HSPA9	2	TP53	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wadhwa R (2002), Wadhwa R (2002), Sun Y (2007), Li Y (2012), Fogeron ML (2013), Horikawa I (2014)	6
RAB35	0	APP	1	pull down	Olah J (2011)	1
FBXO7	1	TBPL1	0	enzymatic study	Teixeira FR (2016)	1
TAF6	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TBPL1	0	TAF1	9	affinity chromatography technology	Jeronimo C (2007)	1
TP53	0	TAF6	4	pull down, affinity chromatography technology, affinity chromatography technology	Wilhelm E (2010), Wilhelm E (2010), Wilhelm E (2010)	3
TBPL1	0	HSPA9	2	affinity chromatography technology	Jeronimo C (2007)	1
GTF2A1	1	TAF4	4	affinity chromatography technology	Jeronimo C (2007)	1
FBXO7	1	HSPA9	2	affinity chromatography technology	Teixeira FR (2016)	1
TBPL1	0	TAF6	4	affinity chromatography technology	Jeronimo C (2007)	1
TAF1	9	TAF4	4	pull down, biochemical, biochemical, affinity chromatography technology	Guermah M (2001), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	4
ELAVL1	0	TERF2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TBP	0	TAF4	4	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Liu X (2008), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Ogryzko VV (1998)	10
GTF2A1	1	TBP	0	pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	DeJong J (1995), Langelier MF (2001), Ozer J (1998), Solow S (2001), Sun X (1994), Jeronimo C (2007), Maldonado E (1990), Mitsiou DJ (2003), Mitsiou DJ (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	12
GTF2A2	0	TBP	0	pull down, pull down, pull down, imaging technique, pull down, pull down	DeJong J (1995), Ozer J (1998), Sun X (1994), Ozer J (1996), Ozer J (1996), Gupta K (2017)	6
RAB35	0	TBPL1	0	two hybrid	Stelzl U (2005)	1
TAF1L	2	TBP	0	two hybrid	Wang PJ (2002)	1
GTF2A1	1	GTF2A2	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Ozer J (1996), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
TBPL1	0	TAF1L	2	affinity chromatography technology	Jeronimo C (2007)	1
PRNP	4	TBPL1	0	pull down	Satoh J (2009)	1
TBPL1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TAF1	9	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cvekl A (1999), Li HH (2004), Li HH (2004), Li HH (2004)	4
TBPL1	0	TAF4	4	affinity chromatography technology	Jeronimo C (2007)	1
TBPL1	0	GTF2B	1	pull down	Rabenstein MD (1999)	1
RPL10	3	TBPL1	0	two hybrid	Stelzl U (2005)	1
FUS	0	TBPL1	0	affinity chromatography technology	Wang T (2014)	1
FUS	0	HSPA9	2	affinity chromatography technology	Wang T (2014)	1
TAF1L	2	TAF4	4	biochemical	Havugimana PC (2012)	1
TBP	0	TAF5	1	affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Bellorini M (1997), Tao Y (1997), Ruppert S (1993), Knuesel MT (2009), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Soutoglou E (2005), Ogryzko VV (1998), Le Douarin B (1995), Wan C (2015)	15
TERF2	2	GTF2A1	1	affinity chromatography technology	Giannone RJ (2010)	1
GTF2B	1	TBP	0	biochemical, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	Scully R (1997), Scully R (1997), Bushnell DA (2004), Friedman MJ (2007), Tsai FT (2000), Bagby S (1995), Lin Y (1997)	7
TAF1	9	GTF2A1	1	enzymatic study	Solow S (2001)	1
TAF4	4	TAF5	1	affinity chromatography technology, biochemical	Brand M (2001), Wan C (2015)	2
TERF2	2	TBPL1	0	affinity chromatography technology	Giannone RJ (2010)	1
TBP	0	TAF6	4	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Nakamura T (2002), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Soutoglou E (2005), Ogryzko VV (1998)	14
GTF2A1	1	TBPL2	1	affinity chromatography technology	Jeronimo C (2007)	1
TNNT1	0	TBPL1	0	two hybrid	Rolland T (2014)	1
TERF1	1	TBPL1	0	affinity chromatography technology	Giannone RJ (2010)	1
HSPA9	2	APP	1	pull down	Olah J (2011)	1
TAF6	4	TAF5	1	pull down, affinity chromatography technology, biochemical, biochemical	Hsieh YJ (1999), Tao Y (1997), Havugimana PC (2012), Wan C (2015)	4
TBPL1	0	GTF2A2	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jeronimo C (2007)	2
GTF2A1	1	TAF6	4	affinity chromatography technology	Jeronimo C (2007)	1
ELAVL1	0	TBPL1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TBPL1	0	TBPL2	1	affinity chromatography technology	Jeronimo C (2007)	1
TBPL1	0	TBP	0	affinity chromatography technology	Jeronimo C (2007)	1
RPL10	3	GTF2B	1	affinity chromatography technology	Hein MY (2015)	1
TAF1L	2	TAF5	1	biochemical	Havugimana PC (2012)	1
ELAVL1	0	TAF4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TERF2	2	GTF2A2	0	affinity chromatography technology	Giannone RJ (2010)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
TBP	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Seto E (1992), Cvekl A (1999), Wu Y (2001), Qadri I (2002), Qadri I (2002), Sommer MH (1994)	6
GTF2A1	1	TAF5	1	affinity chromatography technology	Jeronimo C (2007)	1
TP53	0	TAF5	1	affinity chromatography technology	Li HH (2004)	1
GTF2A2	0	TAF4	4	pull down	Guermah M (2001)	1
TAF5	1	TAF1	9	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tao Y (1997), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	4
TAF1	9	TBP	0	pull down, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Siegert JL (1999), Bellorini M (1997), Ruppert S (1993), OBrien T (1998), Knuesel MT (2009), Hilton TL (2005), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Klemm RD (1995), Dallas PB (1997), Ogryzko VV (1998), Gupta K (2017)	15
TAF6	4	TAF1	9	pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hisatake K (1995), Nakamura T (2002), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	5
TBPL1	0	TAF5	1	affinity chromatography technology	Jeronimo C (2007)	1
TBPL1	0	GTF2A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Teichmann M (1999), Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	5
GTF2A1	1	HSPA9	2	affinity chromatography technology	Jeronimo C (2007)	1
FBXO7	1	RPL10	3	affinity chromatography technology	Teixeira FR (2016)	1