PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
POLR2F	1	POLR3E	1	affinity chromatography technology	Hein MY (2015)	1
HIRA	5	BAG5	0	affinity chromatography technology	Lee JS (2016)	1
SOX2	4	MMS19	5	affinity chromatography technology	Cox JL (2013)	1
LATS2	1	TRIM27	2	bioid	Couzens AL (2013)	1
SNCA	0	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kalia LV (2011), Huang C (2006), Huang C (2006), Lindersson E (2004), Kawakami F (2011), Pemberton S (2011), Klucken J (2006)	7
FBXO25	1	EGFR	5	enzymatic study	Teixeira FR (2013)	1
FAM96B	0	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Gari K (2012), Gari K (2012), Huttlin EL (2015), Huttlin EL (2017)	10
STUB1	4	SNCA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Kalia LV (2011), Kalia LV (2011), Tetzlaff JE (2008)	3
RIPK4	0	FBXW11	2	affinity chromatography technology	Rodriguez J (2016)	1
FBXW11	2	BAG5	0	affinity chromatography technology	Low TY (2014)	1
EGFR	5	BAG5	0	affinity chromatography technology	Yao Z (2017)	1
ABHD15	2	STUB1	4	affinity chromatography technology	Huttlin EL (2017)	1
RMND5A	0	BAG5	0	affinity chromatography technology	Lampert F (2018)	1
KLHL10	1	CUL3	17	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
FBXW11	2	SBF2	5	affinity chromatography technology	Low TY (2014)	1
RIPK4	0	FAM96B	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM27	2	BAG5	0	two hybrid	Rolland T (2014)	1
AMBRA1	7	STUB1	4	affinity chromatography technology	Antonioli M (2014)	1
TP53	0	THAP1	1	genetic interference	Xie L (2013)	1
CUL3	17	AGO3	4	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
GBA2	5	BAG5	0	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	DNAJC13	5	affinity chromatography technology	Yao Z (2017)	1
ABHD15	2	BAG5	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	DNAJC13	5	affinity chromatography technology	Bennett EJ (2010)	1
LLGL2	4	BAG5	0	affinity chromatography technology	Hauri S (2013)	1
STUB1	4	DNAJC13	5	affinity chromatography technology	Tateishi Y (2004)	1
FBXO25	1	BAG5	0	affinity chromatography technology	Teixeira FR (2010)	1
DUSP16	0	BAG5	0	affinity chromatography technology	Yadav L (2017)	1
BAG5	0	BANP	1	two hybrid	Rolland T (2014)	1
RIPK4	0	AMBRA1	7	affinity chromatography technology	Rodriguez J (2016)	1
BAG5	0	MAD2L1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
PINK1	2	BAG5	0	two hybrid, affinity chromatography technology, pull down, pull down	Wang X (2014), Wang X (2014), Wang X (2014), Wang X (2014)	4
AGO3	4	OTUD4	2	affinity chromatography technology	Weinmann L (2009)	1
LRRK2	5	BAG5	0	two hybrid	Zheng XY (2008)	1
FBXW11	2	TP53	0	affinity chromatography technology	Low TY (2014)	1
SOX2	4	BAG5	0	affinity chromatography technology	Cox JL (2013)	1
BANP	1	TP53	0	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pavithra L (2009), Pavithra L (2009), Sinha S (2010), Sinha S (2010), Sinha S (2010), Sinha S (2012), Pavithra L (2009)	7
RMND5A	0	STUB1	4	affinity chromatography technology	Lampert F (2018)	1
FBXW11	2	AMBRA1	7	affinity chromatography technology	Low TY (2014)	1
BAG5	0	STUB1	4	pull down, affinity chromatography technology	Kalia LV (2011), Kalia LV (2011)	2
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
FRMD5	1	BAG5	0	affinity chromatography technology	Hauri S (2013)	1
AMBRA1	7	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Van Humbeeck C (2011), Van Humbeeck C (2011), Van Humbeeck C (2011), Choubey V (2014)	4
MMS19	5	BAG5	0	affinity chromatography technology	Stehling O (2012)	1
BAG5	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kalia LV (2011), Kalia LV (2011), Kalia SK (2004), Kalia SK (2004), Kalia SK (2004), Kalia SK (2004)	6
PRKN	1	BAG5	0	affinity chromatography technology, pull down	Kalia SK (2004), Kalia SK (2004)	2
UIMC1	4	HSPA4	3	affinity chromatography technology	Cho HJ (2013)	1
CUL3	17	DLG5	5	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
UIMC1	4	BAG5	0	affinity chromatography technology	Sowa ME (2009)	1
MAD2L1	0	MAD1L1	2	two hybrid, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Sironi L (2001), Murakumo Y (2000), Chen J (2001), Sironi L (2001), Sironi L (2001), Tipton AR (2011), De Antoni A (2005), De Antoni A (2005), Fava LL (2011), Fava LL (2011), Wang J (2011), Rodriguez-Bravo V (2014), Wang K (2014), Hein MY (2015), Sedgwick GG (2016), Sedgwick GG (2016), Yang M (2008), Kim S (2010), Kim S (2010), Theng SS (2014)	21
PINK1	2	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Moriwaki Y (2008)	2
RIPK4	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	BAG5	0	affinity chromatography technology	Bennett EJ (2010)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
OTUD4	2	BAG5	0	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	MMS19	5	affinity chromatography technology	Bennett EJ (2010)	1
NDRG2	1	BAG5	0	affinity chromatography technology	Huttlin EL (2015)	1
EGFR	5	CIRBP	1	affinity chromatography technology	Yao Z (2017)	1
P2RX6	0	BAG5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	PTPN18	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
POLR2F	1	BAG5	0	affinity chromatography technology	Hein MY (2015)	1
PTPN18	1	BAG5	0	affinity chromatography technology	St-Denis N (2016)	1
LLGL2	4	STUB1	4	affinity chromatography technology	Hauri S (2013)	1
BAG5	0	MAD1L1	2	biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
LATS2	1	BAG5	0	bioid	Couzens AL (2013)	1
SBF2	5	BAG5	0	bioid	St-Denis N (2016)	1
CUL3	17	HIRA	5	affinity chromatography technology	Wimuttisuk W (2014)	1
EGFR	5	ABL2	4	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
CUL3	17	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
BAG5	0	CCDC155	2	two hybrid	Rolland T (2014)	1
PRKN	1	CIRBP	1	affinity chromatography technology	Zanon A (2013)	1
SNCA	0	LRRK2	5	affinity chromatography technology, affinity chromatography technology	Qing H (2009), Qing H (2009)	2
TP53	0	BAG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Horikawa I (2014), Yue X (2016), Yue X (2016), Yue X (2016)	4
BAG5	0	DLG5	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CUL3	17	CIRBP	1	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
ALDH3B1	0	BAG5	0	affinity chromatography technology	Huttlin EL (2015)	1
KCNC4	1	BAG5	0	affinity chromatography technology	Huttlin EL (2017)	1
AGO3	4	BAG5	0	affinity chromatography technology	Hein MY (2015)	1
AMBRA1	7	BAG5	0	affinity chromatography technology	Antonioli M (2014)	1
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
BAG5	0	ABL2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM96B	0	BAG5	0	affinity chromatography technology	Stehling O (2013)	1
RIPK4	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	BAG5	0	affinity chromatography technology	Rodriguez J (2016)	1
EGFR	5	MMS19	5	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
SOX2	4	RMND5A	0	affinity chromatography technology	Cox JL (2013)	1
CUL3	17	MAD2L1	0	affinity chromatography technology	Bennett EJ (2010)	1
BAG5	0	DNAJC13	5	affinity chromatography technology	Huttlin EL (2015)	1
BAG5	0	CIRBP	1	two hybrid	Wang J (2011)	1
LRRK2	5	PRKN	1	affinity chromatography technology, affinity chromatography technology	Smith WW (2005), Smith WW (2005)	2
SNCA	0	BAG5	0	affinity chromatography technology, pull down	Kalia LV (2011), Kalia LV (2011)	2
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
PINK1	2	SNCA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Um JW (2009), Um JW (2009), Szargel R (2016), Szargel R (2016)	4
KLHL10	1	BAG5	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
LRRK2	5	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ho DH (2015), Ho DH (2015), Ho DH (2015)	3
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
BAG5	0	THAP1	1	two hybrid	Rolland T (2014)	1
TP53	0	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BAG5	0	FAM118B	0	two hybrid	Rolland T (2014)	1
LRRK2	5	HSPA4	3	affinity chromatography technology	Sen S (2009)	1
POLR3E	1	BAG5	0	affinity chromatography technology	Huttlin EL (2017)	1
LRRK2	5	STUB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ko HS (2009), Ko HS (2009), Ding X (2009), Ding X (2009), Rudenko IN (2017), Rudenko IN (2017)	6
TP53	0	SBF2	5	genetic interference	Xie L (2013)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
RIPK4	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1