PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLK1	0	TP53BP1	3	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	van Vugt MA (2010), van Vugt MA (2010), van Vugt MA (2010), Benada J (2015), Benada J (2015)	5
GPX3	1	TP53I3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Wang H (2012), Wang H (2012), Wang H (2012), Wang H (2012)	4
TP53BP1	3	H2AFX	1	affinity chromatography technology, imaging technique, imaging technique, unspecified method, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Sengupta S (2004), Sengupta S (2004), Fernandez-Capetillo O (2002), Ward IM (2003), Walters DK (2011), Stewart GS (2003), Fraser M (2011), Rassoolzadeh H (2015)	8
TP53I3	1	EEF1G	0	two hybrid	Stelzl U (2005)	1
TP53I3	1	UNC119	4	two hybrid	Stelzl U (2005)	1
TP53I3	1	FUNDC2	0	two hybrid	Stelzl U (2005)	1
TP53I3	1	UBR1	3	two hybrid	Stelzl U (2005)	1
TP53I3	1	H2AFX	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Lee JH (2010)	3
PLK1	0	TP53I3	1	biochemical	Havugimana PC (2012)	1
TLDC1	3	TP53I3	1	biochemical	Havugimana PC (2012)	1
TP53I3	1	MDM2	2	affinity chromatography technology, pull down	Jin M (2017), Jin M (2017)	2
PLK1	0	MDM2	2	enzymatic study, affinity chromatography technology, pull down	Dias SS (2009), Dias SS (2009), Dias SS (2009)	3
TP53I3	1	TP53BP1	3	imaging technique	Lee JH (2010)	1
TP53I3	1	HMBS	2	biochemical	Wan C (2015)	1