PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCOR1	9	NR1D2	1	genetic interference, pull down	Downes M (1996), Muscat GE (1998)	2
C1D	0	NCOR2	12	pull down	Zamir I (1997)	1
C1D	0	NCOR1	9	pull down, affinity chromatography technology	Zamir I (1997), Zamir I (1997)	2
NR2E3	2	NR1D1	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
NCOR1	9	NR1D1	1	genetic interference, two hybrid	Downes M (1996), Albers M (2005)	2
NR1D1	1	HDAC3	5	affinity chromatography technology	Yin L (2010)	1
C1D	0	APP	1	pull down	Olah J (2011)	1
NR1D1	1	MYCBP2	11	affinity chromatography technology, affinity chromatography technology	Yin L (2010), Yin L (2010)	2
C1D	0	NR1D1	1	pull down, affinity chromatography technology	Zamir I (1997), Zamir I (1997)	2
INPP1	0	NR1D1	1	two hybrid	Corominas R (2014)	1
NR1D2	1	NR1D1	1	affinity chromatography technology	Huttlin EL (2017)	1
NR1D1	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Yin L (2010), Yin L (2010)	2
NR1D1	1	NCOR2	12	pull down	Johnson DR (2006)	1
NR1D1	1	APP	1	pull down	Olah J (2011)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
NCOR2	12	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Fischle W (2002), Fischle W (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Guenther MG (2000), Guenther MG (2000), Kim MY (2006), Wang L (2006), Torres-Padilla ME (2002), Codina A (2005), Wen YD (2000), Rajendran P (2011), Liu A (2006), Bantscheff M (2011), Joshi P (2013), Xu F (2016)	27