PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF14	2	PHF7	5	two hybrid	Woodsmith J (2012)	1
HNF1A	0	RNF14	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Wu B (2013), Wu B (2013), Wu B (2013), Wu B (2013)	4
RNF14	2	TCF3	7	affinity chromatography technology	Wu B (2013)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
DACH1	3	RNF14	2	two hybrid	Rolland T (2014)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
RNF14	2	VDR	2	two hybrid	Ting HJ (2005)	1
UBE2D2	0	RNF14	2	two hybrid	Markson G (2009)	1
RNF14	2	RNF14	2	enzymatic study	Ito K (2001)	1
DET1	2	UBE2E3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Huttlin EL (2017)	4
UBE2E1	1	RNF14	2	two hybrid, two hybrid, pull down	Ito K (2001), Markson G (2009), Ito K (2001)	3
PHF7	5	UBE2D4	0	two hybrid	Rolland T (2014)	1
UBE2U	0	RNF14	2	two hybrid	van Wijk SJ (2009)	1
DET1	2	UBE2E2	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	LEF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Grueneberg DA (2003), Behrens J (1996), Behrens J (1996), Labbe E (2000), Sierra J (2006), Gomes NP (2006), Vietor I (2005), Billin AN (2000), Fischer L (2002), Tutter AV (2001), Sadot E (2002), Feigin ME (2008), Daniels DL (2005), Porfiri E (1997), Porfiri E (1997), Hamada F (2004), Vadlamudi U (2005), Lu D (2012), Lu D (2012)	20
FAM46A	2	RNF14	2	two hybrid	Colland F (2004)	1
CTNNB1	30	RNF14	2	affinity chromatography technology	Wu B (2013)	1
RNF14	2	LEF1	3	affinity chromatography technology	Wu B (2013)	1
TCF3	7	VDR	2	affinity chromatography technology	Kim MS (2007)	1
UBE2D1	0	RNF14	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
RNF14	2	HNRNPA1	1	two hybrid, pull down, affinity chromatography technology	Yang Z (2007), Yang Z (2007), Yang Z (2007)	3
UBE2D3	1	RNF14	2	two hybrid	Markson G (2009)	1
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
DACH1	3	TCF3	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2E3	0	RNF14	2	two hybrid, two hybrid, pull down	Ito K (2001), Markson G (2009), Ito K (2001)	3
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
CTNNB1	30	HNRNPA1	1	affinity chromatography technology, affinity chromatography technology	Tian Q (2004), Sato S (2005)	2
UBE2V1	0	RNF14	2	two hybrid	Markson G (2009)	1
DET1	2	UBE2E1	1	affinity chromatography technology, affinity chromatography technology	Pick E (2007), Huttlin EL (2017)	2
RNF14	2	TAGLN	1	two hybrid, affinity chromatography technology, pull down	Yang Z (2007), Yang Z (2007), Yang Z (2007)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2E2	1	RNF14	2	two hybrid, two hybrid, pull down, two hybrid	Ito K (2001), Markson G (2009), Ito K (2001), Ambivero CT (2014)	4
VTN	1	RNF14	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RNF14	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2W	0	RNF14	2	two hybrid	Markson G (2009)	1
RNF14	2	TCF4	26	affinity chromatography technology, affinity chromatography technology	Wu B (2013), Wu B (2013)	2
TNFAIP3	3	RNF14	2	two hybrid	Hayes SD (2012)	1
DET1	2	RNF14	2	affinity chromatography technology	Pick E (2007)	1
ECT2	2	RNF14	2	affinity chromatography technology	Woods NT (2012)	1
PNPLA7	3	RNF14	2	affinity chromatography technology, affinity chromatography technology	Long DX (2015), Long DX (2015)	2
RNF14	2	AR	3	two hybrid, two hybrid, unspecified method, pull down, two hybrid, two hybrid, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Miyamoto H (2002), He B (2002), He B (2002), Kang HY (1999), Kang HY (1999), He B (2003), He B (2003), Xu K (2009), Albers M (2005), Yang Z (2007), Yang Z (2007), Wang J (2014)	12
CTNNB1	30	TCF4	26	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fasolini M (2003), Li Q (2004), Poy F (2001), Iguchi H (2007), Notani D (2010), Tran H (2008), Sanchez-Tillo E (2011), Selbach M (2006), Hamada F (2004), Hamada F (2004), Ponce E (2014), Wu B (2013), Wu B (2013), Yamamoto H (2003), Xu X (2014), Levy L (2004), Levy L (2004), Levy L (2004), Wang H (2008), Jansson EA (2005), Kotlyar M (2015), Zhu Z (2014), Lu D (2012), Lu D (2012), Lee HK (2007)	25