PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NOD1	3	NOD2	1	affinity chromatography technology, affinity chromatography technology	Travassos LH (2010), Travassos LH (2010)	2
TRAF2	1	TNFRSF9	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Jang IK (1998), Jang IK (1998), Arch RH (1998), Arch RH (1998), Ma BY (2005), Martinez-Forero I (2013), Saoulli K (1998), Saoulli K (1998)	9
BANP	1	FAM90A1	1	two hybrid	Rolland T (2014)	1
LTBR	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
SMURF2	3	TRAF4	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Colland F (2004), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013)	8
BMI1	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
ARNT2	5	PDE4DIP	10	two hybrid	Corominas R (2014)	1
ZNF581	0	BANP	1	two hybrid	Rolland T (2014)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
CBL	7	MYH9	19	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Valiya Veettil M (2011), Valiya Veettil M (2011), Valiya Veettil M (2011), Brehme M (2009)	4
TRAF4	1	HIP1R	5	biochemical	Wan C (2015)	1
PSMC3	0	KDM1A	2	two hybrid	Rolland T (2014)	1
TRAF4	1	UBL4B	0	two hybrid	Rolland T (2014)	1
MAP3K4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
TRAF2	1	SMURF1	4	genetic interference	Li S (2010)	1
LTBR	0	TRAF4	1	pull down	Krajewska M (1998)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
TRAF6	0	WWP1	3	affinity chromatography technology	Lin XW (2013)	1
KRT31	0	TRAF4	1	two hybrid	Rolland T (2014)	1
TRAF4	1	NPAS2	0	two hybrid	Rozan LM (2006)	1
GP6	0	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
FAM90A1	1	KRT40	0	two hybrid	Rolland T (2014)	1
TRAF4	1	BAHD1	3	two hybrid	Rolland T (2014)	1
NGFR	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ye X (1999), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Geetha T (2012), Geetha T (2012)	7
KRT31	0	FAM90A1	1	two hybrid	Rolland T (2014)	1
SMURF1	4	PRMT5	3	affinity chromatography technology	Xie Y (2013)	1
MAP3K7	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu XY (2008), Jiang Z (2002), Jiang Z (2002), Lee HJ (2012), Yao J (2007)	5
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
TRAF2	1	FAM90A1	1	two hybrid	Rolland T (2014)	1
TRAF4	1	WWP2	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SUZ12	0	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
TNFRSF4	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Arch RH (1998), Arch RH (1998), Ma BY (2005)	3
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
TRAF4	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
GP1BB	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
CTNNB1	30	TGFBR2	0	affinity chromatography technology	Tian YC (2002)	1
BMI1	0	KDM1A	2	genetic interference	Wong AS (2016)	1
TRAF2	1	LNX1	7	two hybrid	Rual JF (2005)	1
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
TICAM1	3	TRAF4	1	affinity chromatography technology	Takeshita F (2005)	1
ZNF581	0	KDM1A	2	two hybrid	Weimann M (2013)	1
TRAF4	1	ISYNA1	0	two hybrid	Rolland T (2014)	1
PTK2B	6	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haglund K (2004), Haglund K (2004), Sanjay A (2001), Schmidt MH (2003)	4
TRAF4	1	FBXL18	5	two hybrid	Rolland T (2014)	1
TRAF4	1	MRPL28	1	two hybrid	Rolland T (2014)	1
TRAF4	1	ALKBH4	2	two hybrid	Rolland T (2014)	1
CALCOCO2	0	ZNF581	0	two hybrid	Rolland T (2014)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
PRMT5	3	TYK2	1	pull down	Pollack BP (1999)	1
TRAF4	1	WBP11	0	two hybrid	Rolland T (2014)	1
ARNT2	5	TRIM37	7	two hybrid	Corominas R (2014)	1
TRIM37	7	TRAF4	1	pull down	Zapata JM (2001)	1
GP1BB	1	NCF1	2	pull down, affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011), Arthur JF (2011)	3
SMURF2	3	TRAF2	1	affinity chromatography technology	Carpentier I (2008)	1
CBLC	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TGFBR2	0	CBL	7	pull down, affinity chromatography technology, enzymatic study	Zuo W (2013), Zuo W (2013), Zuo W (2013)	3
BYSL	3	KRT31	0	two hybrid	Rolland T (2014)	1
CALCOCO2	0	BAHD1	3	two hybrid	Rolland T (2014)	1
IRAK1	1	CHUK	5	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
TRAF4	1	ZNF581	0	two hybrid	Rolland T (2014)	1
SMURF1	4	RNF114	0	enzymatic study	Andrews PS (2010)	1
TGFBR2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Kim SI (2009), Kim SI (2009)	2
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
UBL4A	0	RPS6KB1	1	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	KIF11	5	affinity chromatography technology	Xie Y (2013)	1
CHUK	5	MAP3K4	1	enzymatic study	Marinis JM (2012)	1
KDM1A	2	PRMT5	3	genetic interference	Wong AS (2016)	1
CALCOCO2	0	BCL6B	0	two hybrid	Rolland T (2014)	1
WWP2	7	FBXL18	5	two hybrid	Rolland T (2014)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
LNX1	7	MYH9	19	affinity chromatography technology	Lenihan JA (2017)	1
BYSL	3	TRIM37	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TRAF6	0	PSMC3	0	affinity chromatography technology	Bouwmeester T (2004)	1
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
TGFBR2	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
BMI1	0	TRAF4	1	affinity chromatography technology	Cao Q (2014)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
USP7	14	TRAF4	1	pull down, affinity chromatography technology, affinity chromatography technology	Zapata JM (2001), Yi P (2013), Yi P (2013)	3
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM214B	1	TRAF4	1	two hybrid	Yu H (2011)	1
BMI1	0	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010), de Bie P (2010), Lecona E (2015), Lecona E (2015)	6
GP1BB	1	TRAF4	1	pull down, affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011), Arthur JF (2011)	3
TRAF4	1	SPDL1	2	two hybrid	Rolland T (2014)	1
TRAF4	1	CALCOCO2	0	two hybrid	Rozan LM (2006)	1
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
GP6	0	NCF1	2	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
CALCOCO2	0	LNX1	7	two hybrid	Rual JF (2005)	1
NCF2	0	NCF1	2	pull down, pull down, far western blotting, pull down, unspecified method, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology	Lapouge K (2002), Leto TL (1994), Leto TL (1994), Rinckel LA (1999), Dahan I (2002), Kami K (2002), Kami K (2002), Takeshita F (2005), Marty C (2006), Marty C (2006)	10
PDE4DIP	10	KDM1A	2	two hybrid	Weimann M (2013)	1
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
MAGEC2	0	TRAF4	1	two hybrid	Kozakova L (2015)	1
TRAF4	1	MYH9	19	affinity chromatography technology	Rozan LM (2006)	1
TRAF4	1	BANP	1	two hybrid	Rolland T (2014)	1
LNX1	7	WWP1	3	two hybrid	Wolting CD (2011)	1
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
UBL4A	0	PRMT5	3	affinity chromatography technology	Xu Y (2012)	1
TRAF6	0	UBE2O	5	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
UBL4A	0	RPL14	2	affinity chromatography technology	Xu Y (2012)	1
TRAF4	1	WWP1	3	two hybrid	Rolland T (2014)	1
TRAF4	1	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
TRAF4	1	NOD2	1	affinity chromatography technology, affinity chromatography technology	Marinis JM (2011), Marinis JM (2011)	2
AKT1	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014)	2
USP7	14	MYH9	19	affinity chromatography technology	Bhattacharya S (2015)	1
TRAF4	1	TRAF4	1	affinity chromatography technology, two hybrid, pull down	Pullen SS (1998), Rolland T (2014), Rousseau A (2013)	3
NCF1	2	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
TGFBR2	0	TYK2	1	affinity chromatography technology	Huttlin EL (2015)	1
FAM90A1	1	TRAF4	1	two hybrid	Yu H (2011)	1
LNX1	7	TYK2	1	affinity chromatography technology	Wolting CD (2011)	1
TRAF4	1	KDM1A	2	two hybrid	Weimann M (2013)	1
UBL4A	0	TRAF4	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
TRAF4	1	GPRASP1	5	two hybrid	Rozan LM (2006)	1
TYK2	1	TRAF4	1	two hybrid	Rolland T (2014)	1
BMI1	0	WBP11	0	affinity chromatography technology	Cao Q (2014)	1
RPL14	2	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF4	1	DTX3	4	two hybrid	Woodsmith J (2012)	1
TRAF4	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozan LM (2006), Yang F (2015), Yang F (2015)	3
CBL	7	TRAF4	1	two hybrid	Woodsmith J (2012)	1
TRAF4	1	TBC1D7	1	two hybrid	Rolland T (2014)	1
CD40	3	CBL	7	affinity chromatography technology	Deregibus MC (2003)	1
TGFBR1	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Ebisawa T (2001), Murakami G (2003)	3
CALCOCO2	0	FAM90A1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
FBXL18	5	KRT40	0	two hybrid	Rolland T (2014)	1
GP6	0	PTK2B	6	affinity chromatography technology	Arthur JF (2011)	1
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
TRAF2	1	BANP	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NOD1	3	RIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down	Inohara N (1999), Hirata Y (2006), Ver Heul AM (2013)	3
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
SMURF2	3	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Hsu HY (2014)	2
SMURF2	3	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Yan X (2011), Cai Y (2012), Cai Y (2012), Zhang L (2013), Chandhoke AS (2015), Hsu HY (2014)	7
CALCOCO2	0	TRAF6	0	two hybrid	Wang J (2011)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
RPS6KB1	1	AKT1	1	biochemical, imaging technique	Berven LA (2004), Chen TC (2014)	2
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
PDE4DIP	10	ZNF581	0	two hybrid	Rolland T (2014)	1
NOD2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Kim JY (2008), Chen CM (2004), Chen CM (2004), Chen CM (2004), Chen CM (2004), Windheim M (2007)	6
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
ARNT2	5	NPAS2	0	two hybrid	Corominas R (2014)	1
TRAF2	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2013), Zhang X (2013), Zhang X (2013), Ren HY (2015)	4
TGFBR1	2	TGFBR2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Kawabata M (1995), Razani B (2001), Yan X (2011), Yan X (2009), Kim SI (2009), Kim SI (2009), Datta PK (2000), Perlman R (2001), Cho W (2015)	9
TRAF2	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
TYK2	1	CBL	7	affinity chromatography technology	Uddin S (1996)	1
TGFB1I1	2	PTK2B	6	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Matsuya M (1998), Wang X (2002), Wang X (2002), Wang X (2002), Wang X (2002), Matsuya M (1998), Matsuya M (1998), Thomas SM (1999)	8
TGFBR2	0	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Cao Q (2016)	4
TRAF4	1	KRT40	0	two hybrid	Rolland T (2014)	1
IRAK1	1	TRAF4	1	affinity chromatography technology	Takeshita F (2005)	1
QARS	1	TRAF2	1	two hybrid	Rual JF (2005)	1
CD40	3	CHUK	5	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TRIM37	7	SUZ12	0	biochemical, affinity chromatography technology, affinity chromatography technology	Bhatnagar S (2014), Bhatnagar S (2014), Bhatnagar S (2014)	3
ARNT2	5	TRAF4	1	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
TRAF4	1	GORASP2	1	two hybrid	Rolland T (2014)	1
MRPL28	1	BANP	1	two hybrid	Rolland T (2014)	1
USP15	4	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
ZNF581	0	LNX1	7	two hybrid	Rolland T (2014)	1
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
TRAF2	1	KANSL1	11	two hybrid	Rual JF (2005)	1
TRAF4	1	KIF11	5	affinity chromatography technology	Rozan LM (2006)	1
TRAF4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
CENPE	1	TRAF4	1	two hybrid	Du J (2009)	1
TRAF4	1	441362	0	two hybrid	Rolland T (2014)	1
BYSL	3	PDE4DIP	10	two hybrid	Rolland T (2014)	1
ARNT2	5	CALCOCO2	0	two hybrid	Corominas R (2014)	1
TRAF2	1	BAHD1	3	two hybrid	Rual JF (2005)	1
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
CBLC	1	TGFB1I1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Ryan PE (2012), Ryan PE (2012), Desai LP (2014)	3
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
TRAF4	1	RNF114	0	two hybrid	Woodsmith J (2012)	1
TRAF2	1	GORASP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HOMEZ	2	LNX1	7	two hybrid	Rolland T (2014)	1
ZNF581	0	KRT40	0	two hybrid	Rolland T (2014)	1
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
BYSL	3	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF512B	2	TRAF4	1	two hybrid	Colland F (2004)	1
CD40	3	USP15	4	affinity chromatography technology	Ewing RM (2007)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
TRAF4	1	EXOC7	3	two hybrid	Rolland T (2014)	1
SUZ12	0	TRAF4	1	affinity chromatography technology	Cao Q (2014)	1
NGFR	3	TRAF2	1	affinity chromatography technology, pull down	Ye X (1999), Ye X (1999)	2
CTNNB1	30	USP15	4	affinity chromatography technology, affinity chromatography technology	Greenblatt MB (2016), Greenblatt MB (2016)	2
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
GP1BB	1	TGFB1I1	2	pull down, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
SUMO1	0	TRAF4	1	two hybrid	Rolland T (2014)	1
TYK2	1	KRT40	0	two hybrid	Rolland T (2014)	1
ARNT2	5	TRAF2	1	two hybrid	Corominas R (2014)	1
TNFRSF9	1	TNFRSF4	1	affinity chromatography technology, affinity chromatography technology	Ma BY (2005), Ma BY (2005)	2
WWP2	7	PRMT5	3	affinity chromatography technology	Chaudhary N (2014)	1
SMURF1	4	BYSL	3	affinity chromatography technology	Xie Y (2013)	1
TGFBR1	2	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Eichhorn PJ (2012), Zhang L (2013), Herhaus L (2014)	3
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
BAHD1	3	KDM1A	2	two hybrid	Weimann M (2013)	1
TRIM37	7	BMI1	0	imaging technique	Bhatnagar S (2014)	1
ZNF3	0	TRAF4	1	two hybrid	Rolland T (2014)	1
USP7	14	ARNT2	5	two hybrid	Lim J (2006)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
CD40	3	TRAF4	1	affinity chromatography technology	Werneburg BG (2001)	1
TRAF4	1	339044	0	two hybrid	Rolland T (2014)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
USP7	14	SUZ12	0	pull down	de Bie P (2010)	1
TRAF4	1	NOS1AP	0	two hybrid	Rolland T (2014)	1
TRAF4	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Wang A (2014), Wang A (2014)	2
TRAF4	1	TNFRSF9	1	affinity chromatography technology	Ma BY (2005)	1
AKT1	1	IRAK1	1	affinity chromatography technology	Chen BC (2002)	1
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
KANSL1	11	KDM1A	2	two hybrid	Weimann M (2013)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
TRAF4	1	FTH1	0	two hybrid	Rozan LM (2006)	1
WWP1	3	FBXL18	5	two hybrid	Rolland T (2014)	1
TRAF4	1	PSMC3	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rozan LM (2006), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF4	1	HOMEZ	2	two hybrid	Rolland T (2014)	1
PSMC3	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAHD1	3	KRT40	0	two hybrid	Rolland T (2014)	1
FAT1	12	TRAF4	1	two hybrid	de Bock CE (2017)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
NCF2	0	TRAF4	1	affinity chromatography technology	Takeshita F (2005)	1
MIA2	5	TRAF4	1	affinity chromatography technology	Huttlin EL (2017)	1
CHUK	5	TRAF4	1	enzymatic study	Marinis JM (2012)	1
KRT31	0	PDE4DIP	10	two hybrid	Rolland T (2014)	1
TRAF4	1	TNFRSF4	1	affinity chromatography technology	Ma BY (2005)	1
USP15	4	KRT31	0	affinity chromatography technology	Sowa ME (2009)	1
NGFR	3	TRAF4	1	affinity chromatography technology, pull down, pull down	Ye X (1999), Ye X (1999), Krajewska M (1998)	3
GP6	0	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Arthur JF (2011), Arthur JF (2011)	2
CALCOCO2	0	FBXL18	5	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NCF1	2	TRAF4	1	affinity chromatography technology, two hybrid	Xu YC (2002), Takeshita F (2005)	2
TP53BP2	5	TRAF4	1	two hybrid	Rolland T (2014)	1
TRAF4	1	MAP3K4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abell AN (2005), Abell AN (2005), Marinis JM (2011), Marinis JM (2011)	4
QARS	1	TRAF4	1	two hybrid	Rolland T (2014)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
LTBR	0	TRIM37	7	pull down	Zapata JM (2001)	1
TGFBR1	2	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
NGFR	3	TRIM37	7	pull down	Zapata JM (2001)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
CALCOCO2	0	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF4	1	NOD1	3	affinity chromatography technology	Marinis JM (2011)	1
CTNNB1	30	CHUK	5	affinity chromatography technology, pull down, enzymatic study	Lamberti C (2001), Lamberti C (2001), Albanese C (2003)	3
TRAF4	1	RPS6KB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fleckenstein DS (2003), Ren HY (2015), Ren HY (2015)	3
TRAF4	1	CBLC	1	two hybrid	Woodsmith J (2012)	1
USP15	4	SPDL1	2	two hybrid	Rolland T (2014)	1
BYSL	3	TRAF4	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LNX1	7	TRAF4	1	affinity chromatography technology	Lenihan JA (2017)	1
TRAF4	1	TGFB1I1	2	affinity chromatography technology	Arthur JF (2011)	1
TRIM37	7	CTNNB1	30	affinity chromatography technology	Jiang J (2016)	1
SMURF1	4	TRAF4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Li S (2010), Li S (2010), Li S (2010), Li S (2010), Li S (2010), Zhang L (2013)	6
TRAF4	1	MAP3K7	2	affinity chromatography technology	Zhang L (2013)	1
TRAF4	1	BCL6B	0	two hybrid	Rolland T (2014)	1
MYH9	19	HIP1R	5	affinity chromatography technology	Hein MY (2015)	1
TRAF4	1	PDE4DIP	10	two hybrid	Rozan LM (2006)	1
ZNF512B	2	PDE4DIP	10	two hybrid	Colland F (2004)	1
WWP2	7	USP15	4	affinity chromatography technology	Chaudhary N (2014)	1
TRAF4	1	KANSL1	11	two hybrid	Rolland T (2014)	1
CATSPER4	2	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2