PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAF1D	0	FEZ1	0	two hybrid	Vinayagam A (2011)	1
PAM16	0	FEZ1	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PTPRS	15	FEZ1	0	two hybrid	Stelzl U (2005)	1
BARD1	4	LRIF1	3	two hybrid	Goehler H (2004)	1
FEZ1	0	PRKCZ	5	affinity chromatography technology, affinity chromatography technology	Kuroda S (1999), Kuroda S (1999)	2
PLK1	0	DNAAF5	4	affinity chromatography technology	Hein MY (2015)	1
FEZ1	0	HTT	14	pull down, two hybrid, affinity chromatography technology	Goehler H (2004), Goehler H (2004), Huttlin EL (2017)	3
DISC1	6	IMMT	0	two hybrid, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Park YU (2010), Park YU (2010), Park YU (2010), Park YU (2010), Park YU (2010), Park YU (2010), Camargo LM (2007)	7
NDUFB9	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	ASPM	9	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	SELENON	4	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	TUBA3C	1	affinity chromatography technology	Huttlin EL (2017)	1
LRIF1	3	HAP1	1	two hybrid, two hybrid	Goehler H (2004), Goehler H (2004)	2
WWC1	5	LRIF1	3	two hybrid	Stelzl U (2005)	1
CSTF2	2	FEZ1	0	two hybrid	Stelzl U (2005)	1
FEZ2	0	TBC1D25	3	two hybrid	Assmann EM (2006)	1
FEZ1	0	LANCL2	1	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	SAP30L	0	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
FEZ1	0	WWC1	5	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
P4HB	1	SERPINH1	2	biochemical	Havugimana PC (2012)	1
GTF2F1	0	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	SCOC	3	two hybrid, affinity chromatography technology	Assmann EM (2006), Huttlin EL (2017)	2
CSTF2	2	IMMT	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	LRIF1	3	two hybrid	Goehler H (2004)	1
FEZ1	0	SMC3	16	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
FEZ1	0	BRD1	5	two hybrid	Assmann EM (2006)	1
BARD1	4	HAP1	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
TAC3	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	FEZ1	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
PPP4R3B	3	FEZ1	0	two hybrid	Stelzl U (2005)	1
FEZ2	0	SMC3	16	two hybrid	Assmann EM (2006)	1
FEZ2	0	DRAP1	2	two hybrid	Assmann EM (2006)	1
TOMM20	0	HAP1	1	two hybrid	Stelzl U (2005)	1
BARD1	4	AURKA	1	affinity chromatography technology	Bosse KR (2012)	1
OLFML3	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
TOMM20	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
AURKA	1	TLK2	16	affinity chromatography technology, enzymatic study	Li Z (2007), Li Z (2007)	2
FEZ1	0	SCCPDH	2	affinity chromatography technology	Huttlin EL (2017)	1
TOMM20	0	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ2	0	CLASP2	4	two hybrid	Assmann EM (2006)	1
AURKA	1	TAF9	2	affinity chromatography technology	Hein MY (2015)	1
CCL7	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
WWC1	5	PRKCZ	5	two hybrid, pull down, enzymatic study, affinity chromatography technology	Buether K (2004), Buether K (2004), Buether K (2004), Huttlin EL (2017)	4
FEZ1	0	SPECC1L	5	affinity chromatography technology	Huttlin EL (2017)	1
FEZ2	0	BRD1	5	two hybrid	Assmann EM (2006)	1
FEZ1	0	ACTG1	5	affinity chromatography technology	Miyoshi K (2003)	1
TAF1D	0	PTN	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
NDUFB9	0	HAP1	1	two hybrid	Stelzl U (2005)	1
FEZ2	0	PDCD7	0	two hybrid	Assmann EM (2006)	1
FEZ1	0	PLK1	0	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	ATP12A	5	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	MYO5A	17	affinity chromatography technology	Huttlin EL (2017)	1
C8orf33	3	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
NEK1	6	FEZ1	0	two hybrid, pull down	Surpili MJ (2003), Surpili MJ (2003)	2
FEZ1	0	TLK2	16	two hybrid	Assmann EM (2006)	1
GTF2F1	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
DISC1	6	SMC3	16	two hybrid	Camargo LM (2007)	1
FEZ1	0	SMARCD1	5	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
TAF1D	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
FEZ1	0	IFT140	4	affinity chromatography technology	Huttlin EL (2017)	1
NDUFB9	0	IMMT	0	two hybrid	Stelzl U (2005)	1
TAF1D	0	IMMT	0	two hybrid	Vinayagam A (2011)	1
TXNDC9	0	IMMT	0	two hybrid	Stelzl U (2005)	1
PTH	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	DRAP1	2	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
FEZ2	0	ZNF251	1	two hybrid	Assmann EM (2006)	1
FEZ1	0	AURKA	1	affinity chromatography technology	Huttlin EL (2017)	1
FEZ2	0	TLK2	16	two hybrid	Assmann EM (2006)	1
FEZ1	0	CEP192	5	affinity chromatography technology	Huttlin EL (2017)	1
HAP1	1	FEZ1	0	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
PRKCZ	5	FEZ2	0	affinity chromatography technology, affinity chromatography technology	Fujita T (2004), Fujita T (2004)	2
IMMT	0	LRIF1	3	two hybrid	Goehler H (2004)	1
FEZ1	0	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
NBR1	0	FEZ1	0	two hybrid, affinity chromatography technology	Whitehouse C (2002), Whitehouse C (2002)	2
C8orf33	3	FEZ1	0	two hybrid	Vinayagam A (2011)	1
FEZ1	0	KLHDC2	1	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	ANK3	16	affinity chromatography technology	Huttlin EL (2017)	1
BARD1	4	CSTF2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (1999), Kleiman FE (1999), Cevher MA (2010)	5
FEZ1	0	RAB3GAP1	5	two hybrid	Assmann EM (2006)	1
HTATSF1	3	FEZ1	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	NELFA	2	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	ZNF251	1	two hybrid	Assmann EM (2006)	1
FEZ1	0	FEZ2	0	two hybrid	Assmann EM (2006)	1
GEMIN7	0	FEZ1	0	two hybrid	Vinayagam A (2011)	1
FEZ1	0	DGKD	6	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	MED25	1	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	TBC1D25	3	two hybrid	Assmann EM (2006)	1
FEZ1	0	MRS2	3	affinity chromatography technology	Huttlin EL (2017)	1
FEZ1	0	UBE4B	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Okumura F (2004), Okumura F (2004), Okumura F (2004)	3
HAP1	1	HTT	14	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Li XJ (1995), Li SH (1998), Li SH (1998), Li SH (1998), Li XJ (1995), Li XJ (1995), Li SH (1998), Goehler H (2004), Goehler H (2004)	9
BARD1	4	FEZ1	0	two hybrid	Goehler H (2004)	1
FEZ1	0	CKAP4	0	affinity chromatography technology	Huttlin EL (2017)	1
C8orf33	3	IMMT	0	two hybrid	Vinayagam A (2011)	1
PRKCZ	5	CKAP4	0	affinity chromatography technology	So J (2015)	1
P4HB	1	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	ZNF638	8	affinity chromatography technology	Huttlin EL (2017)	1
COL9A2	4	HAP1	1	two hybrid	Stelzl U (2005)	1
FEZ1	0	FEZ1	0	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
IMMT	0	HAP1	1	two hybrid	Goehler H (2004)	1
COL9A2	4	FEZ1	0	two hybrid	Stelzl U (2005)	1
TUBA3C	1	TXNDC9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAF9	2	DRAP1	2	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Rolland T (2014), Yu H (2011)	4
BARD1	4	PTN	0	two hybrid	Goehler H (2004)	1
DISC1	6	FEZ1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Miyoshi K (2003), Miyoshi K (2003), Miyoshi K (2003)	3
DIS3L2	8	FEZ1	0	two hybrid	Stelzl U (2005)	1
TTR	0	FEZ1	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
NEK1	6	FEZ2	0	two hybrid, pull down	Surpili MJ (2003), Surpili MJ (2003)	2
FEZ2	0	WWC1	5	two hybrid	Assmann EM (2006)	1
HTT	14	NBR1	0	affinity chromatography technology	Filimonenko M (2010)	1
BORA	0	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seki A (2008), Seki A (2008), Svendsen JM (2009), Zou J (2013), Huttlin EL (2015), Huttlin EL (2017)	6
TAF9	2	FEZ1	0	pull down	Miyamoto-Sato E (2010)	1
FEZ1	0	IMMT	0	two hybrid	Goehler H (2004)	1
P4HB	1	FEZ1	0	two hybrid	Stelzl U (2005)	1
ZNF638	8	TBC1D25	3	affinity chromatography technology	Boldt K (2016)	1
PLK1	0	SMC3	16	biochemical	Wan C (2015)	1
DISC1	6	ACTG1	5	two hybrid	Camargo LM (2007)	1
FEZ2	0	SCOC	3	two hybrid, affinity chromatography technology	Assmann EM (2006), Huttlin EL (2017)	2
TAC3	0	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	TEDC2	0	two hybrid	Assmann EM (2006)	1
FEZ2	0	TEDC2	0	two hybrid	Assmann EM (2006)	1
FEZ2	0	SAP30L	0	two hybrid	Assmann EM (2006)	1
MEST	2	FEZ1	0	two hybrid	Vinayagam A (2011)	1
SERPINH1	2	FEZ1	0	two hybrid	Vinayagam A (2011)	1
STAR	1	FEZ1	0	two hybrid	Stelzl U (2005)	1
DNAAF5	4	FEZ1	0	two hybrid	Stelzl U (2005)	1
AURKA	1	CEP192	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Hutchins JR (2010), Fogeron ML (2013), Huttlin EL (2015), Firat-Karalar EN (2014), Huttlin EL (2017)	5
PDCD7	0	HAP1	1	two hybrid	Stelzl U (2005)	1
PTN	0	FEZ1	0	two hybrid	Goehler H (2004)	1
FEZ2	0	RAI14	4	two hybrid	Assmann EM (2006)	1
PDCD7	0	FEZ1	0	two hybrid, two hybrid	Stelzl U (2005), Assmann EM (2006)	2
FEZ2	0	RAB3GAP1	5	two hybrid	Assmann EM (2006)	1
TAF1D	0	LRIF1	3	two hybrid	Vinayagam A (2011)	1
FEZ1	0	CLASP2	4	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
FEZ1	0	ZYG11A	3	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	HTT	14	affinity chromatography technology	Lee J (2005)	1
PTPRS	15	PTN	0	two hybrid	Stelzl U (2005)	1
FEZ1	0	RAI14	4	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
BORA	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
AURKA	1	PLK1	0	affinity chromatography technology, biochemical	Katayama H (2008), Havugimana PC (2012)	2
PLK1	0	RAI14	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2