PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC25B	4	PPM1F	1	affinity chromatography technology	St-Denis N (2016)	1
IGF1R	5	PPM1F	1	affinity chromatography technology	Yao Z (2017)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
TRIO	31	PPM1F	1	biochemical	Wan C (2015)	1
ELAVL1	0	CEP164	6	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP164	6	PPM1F	1	bioid	Gupta GD (2015)	1
PPM1F	1	FEM1B	1	affinity chromatography technology, pull down	Tan KM (2001), Tan KM (2001)	2
ROR2	0	PPM1F	1	two hybrid	Yao Z (2017)	1
EGFR	5	FBXO6	0	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Liu B (2012)	2
EGFR	5	ARHGEF7	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
LMTK2	8	PPM1F	1	two hybrid	Yao Z (2017)	1
NTRK1	1	PSMA3	1	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	PRKAA1	2	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
PSMA3	1	PPM1F	1	affinity chromatography technology	Fedorova OA (2011)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
MUC20	4	PPM1F	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	IGF1R	5	affinity chromatography technology	Emdal KB (2015)	1
PRKAA2	1	PRKAA1	2	affinity chromatography technology	Behrends C (2010)	1
ERBB2	6	PPM1F	1	two hybrid	Yao Z (2017)	1
AATK	6	PPM1F	1	two hybrid	Yao Z (2017)	1
PPM1F	1	CAMK2A	6	enzymatic study	Tan KM (2001)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
INSR	9	PRKAA2	1	affinity chromatography technology	Boutchueng-Djidjou M (2015)	1
EGFR	5	PPM1F	1	affinity chromatography technology	Yao Z (2017)	1
ELAVL1	0	PRKAA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	PSMA3	1	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PTK7	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
FBXO6	0	PPM1F	1	affinity chromatography technology	Liu B (2012)	1
EGFR	5	PRKAA1	2	affinity chromatography technology	Tong J (2014)	1
ELAVL1	0	PPM1F	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	TRIO	31	affinity chromatography technology	Emdal KB (2015)	1
ERBB3	3	PPM1F	1	two hybrid	Yao Z (2017)	1
FBXO6	0	IGF1R	5	affinity chromatography technology	Liu B (2012)	1
PPM1F	1	PRKAA2	1	affinity chromatography technology, affinity chromatography technology	Voss M (2011), Voss M (2011)	2
FBXO6	0	PSMA3	1	affinity chromatography technology	Liu B (2012)	1
NTRK1	1	ARHGEF7	3	affinity chromatography technology	Emdal KB (2015)	1
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
ERBB4	5	PPM1F	1	two hybrid	Yao Z (2017)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
NTRK1	1	PPM1F	1	affinity chromatography technology	Emdal KB (2015)	1
PTK7	8	PPM1F	1	two hybrid	Yao Z (2017)	1
INSR	9	PPM1F	1	affinity chromatography technology	Yao Z (2017)	1
FAM161A	2	PPM1F	1	two hybrid	Stelzl U (2005)	1
ROR1	2	PPM1F	1	two hybrid	Yao Z (2017)	1
AATK	6	CDC25B	4	two hybrid	Yao Z (2017)	1
NTRK1	1	ROR2	0	affinity chromatography technology	Emdal KB (2015)	1
PPM1F	1	ARHGEF7	3	pull down	Koh CG (2002)	1
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
NTRK1	1	PRKAA1	2	affinity chromatography technology	Emdal KB (2015)	1
PPM1F	1	PRKAA1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Voss M (2011), Voss M (2011), Voss M (2011)	3