Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ZNF432	rs3752120	TT	adrenergics, inhalants	efficacy	yes	This is stated as "Having 2 copies of the mutant allele and not being treated with inhaled corticosteroids produces a higher bronchodilator response than having 2 mutant alleles and being treated with inhaled corticosteroids(ICS)." By "mutant" allele, presumably the minor allele (T) is meant. CAMP has 3 arms: budesonide,nedocromil and placebo. Subjects in the budesonide arm were considered exposed to ICS. For LOCCS(which was used as a replication cohort), subjects who said that they had used ICS either daily or 2-6x/wk over the past 6 months were considered to have used ICS. Subjects who responded: "1-2x/month", "<1x/month" or "never" were considered to not have used ICS. A comparison between genotypes was not done. The authors state that the clinical implication is not clear,and that "Inhaled corticosteroids appear to modulate the association of bronchodilator response with variant(s) in the ZNF432 gene among adults and children with asthma."	Genotype TT is associated with decreased response to adrenergics, inhalants, beclomethasone, budesonide, corticosteroids, fluticasone propionate, fluticasone/salmeterol or salbutamol in people with Asthma.	24280104	1183698784