PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AZI2	1	N4BP1	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
HYPK	2	N4BP1	3	affinity chromatography technology	Choudhury KR (2012)	1
CUL3	17	N4BP1	3	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CDH1	4	N4BP1	3	bioid	Guo Z (2014)	1
ITCH	1	N4BP1	3	affinity chromatography technology, pull down	Oberst A (2007), Oberst A (2007)	2
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
LSM1	0	N4BP1	3	two hybrid	Lehner B (2004)	1
UBC	7	N4BP1	3	pull down, affinity chromatography technology, pull down	Fenner BJ (2009), Fenner BJ (2009), Zhang X (2017)	3
CDH1	4	UBC	7	bioid	Guo Z (2014)	1
CDK6	0	N4BP1	3	enzymatic study	Anders L (2011)	1
FAM114A1	0	N4BP1	3	biochemical	Kristensen AR (2012)	1