PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLA2	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
ULK2	0	ZNF32	0	two hybrid	Wang J (2011)	1
CBX6	1	ULK2	0	affinity chromatography technology	Vandamme J (2011)	1
LNX1	7	SYNGAP1	65	affinity chromatography technology	Lenihan JA (2017)	1
ULK2	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
ULK1	8	GABARAPL2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method	Okazaki N (2000), Okazaki N (2000), Behrends C (2010), Alemu EA (2012), Alemu EA (2012)	5
GABARAP	0	ULK2	0	unspecified method	Alemu EA (2012)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
DIXDC1	4	ULK2	0	two hybrid	Wang J (2011)	1
SQSTM1	0	ULK1	8	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ro SH (2014), Ro SH (2014), Lim J (2015), Lim J (2015)	4
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
ULK2	0	RB1CC1	9	affinity chromatography technology	Behrends C (2010)	1
ULK1	8	RB1CC1	9	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Rui YN (2015)	2
ULK2	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
ULK1	8	ULK2	0	genetic interference	Goodwin JM (2017)	1
ULK2	0	SYNGAP1	65	pull down	Tomoda T (2004)	1
ULK1	8	GABARAP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Ewing RM (2007), Okazaki N (2000), Okazaki N (2000), Alemu EA (2012), Alemu EA (2012), Dunlop EA (2014)	6
GABARAPL2	0	ULK2	0	unspecified method	Alemu EA (2012)	1
NASP	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
ULK2	0	NASP	3	two hybrid	Stelzl U (2005)	1
ULK1	8	SYNGAP1	65	two hybrid, pull down, affinity chromatography technology	Tomoda T (2004), Tomoda T (2004), Tomoda T (2004)	3
GABARAP	0	RB1CC1	9	affinity chromatography technology, unspecified method	Alemu EA (2012), Alemu EA (2012)	2
LNX1	7	ULK2	0	two hybrid	Wang J (2011)	1
SETDB1	3	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
SQSTM1	0	ULK2	0	pull down	Pridgeon JW (2004)	1
ULK2	0	POLA2	2	two hybrid	Stelzl U (2005)	1