PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DTNBP1	1	DCTN1	6	two hybrid	Camargo LM (2007)	1
YWHAG	5	KIAA0408	0	two hybrid	Rual JF (2005)	1
KIAA0408	0	BEGAIN	3	two hybrid	Rual JF (2005)	1
ABI3	1	DTNBP1	1	two hybrid	Rual JF (2005)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
KRT15	2	ABI3	1	two hybrid	Rual JF (2005)	1
VIM	0	KIAA0408	0	two hybrid	Rual JF (2005)	1
MDFI	1	KIAA0408	0	two hybrid	Rual JF (2005)	1
KIAA0408	0	CEP72	0	two hybrid	Rual JF (2005)	1
TRAF2	1	KIAA0408	0	two hybrid	Rual JF (2005)	1
KIAA0408	0	PRMT6	2	two hybrid	Weimann M (2013)	1
GFAP	0	KIAA0408	0	two hybrid	Rual JF (2005)	1
KIAA0408	0	SORBS3	5	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
CCDC85B	0	CARD9	3	two hybrid	Rual JF (2005)	1
KIAA0408	0	ABI3	1	two hybrid	Rual JF (2005)	1
KIAA0408	0	KDM1A	2	two hybrid	Weimann M (2013)	1
AP2B1	3	KIAA0408	0	two hybrid	Rual JF (2005)	1
PFDN1	0	DCTN1	6	two hybrid	Vinayagam A (2011)	1
KIAA0408	0	HOOK2	0	two hybrid	Rual JF (2005)	1
SFN	1	KIAA0408	0	two hybrid	Rual JF (2005)	1
GFAP	0	KRT15	2	two hybrid	Rolland T (2014)	1
DTNBP1	1	KIAA0408	0	two hybrid	Camargo LM (2007)	1
TRIM37	7	KIAA0408	0	two hybrid	Rual JF (2005)	1
XRCC6	3	KIAA0408	0	two hybrid	Vinayagam A (2011)	1
KRT15	2	KIAA0408	0	two hybrid	Rual JF (2005)	1
KIAA0408	0	CCDC85B	0	two hybrid	Rual JF (2005)	1
TLE1	6	KIAA0408	0	two hybrid	Vinayagam A (2011)	1
DCTN1	6	KIAA0408	0	two hybrid	Vinayagam A (2011)	1
MAGEA11	1	KIAA0408	0	two hybrid	Rual JF (2005)	1
GFAP	0	VIM	0	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
KIAA0408	0	TEX11	0	two hybrid	Rual JF (2005)	1
ZDHHC17	1	KIAA0408	0	two hybrid	Butland SL (2014)	1
KIAA0408	0	CARD9	3	two hybrid	Rual JF (2005)	1
PFDN1	0	KIAA0408	0	two hybrid	Vinayagam A (2011)	1
YWHAG	5	VIM	0	affinity chromatography technology	Jin J (2004)	1
DCTN1	6	VIM	0	affinity chromatography technology	Payne C (2003)	1