PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADRB1	3	GPRASP1	5	pull down	Simonin F (2004)	1
4985	0	GPRASP1	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Whistler JL (2002), Whistler JL (2002), Whistler JL (2002), Whistler JL (2002), Simonin F (2004), Simonin F (2004), Simonin F (2004)	7
OFD1	3	GPRASP1	5	two hybrid	Stelzl U (2005)	1
PBK	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
C8orf33	3	GPRASP1	5	two hybrid	Stelzl U (2005)	1
HMOX2	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
HTR7	2	GPRASP1	5	pull down	Simonin F (2004)	1
STMN2	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
PFDN1	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
MAP7D1	2	GPRASP1	5	two hybrid	Stelzl U (2005)	1
MARK2	6	GPRASP1	5	affinity chromatography technology	Sowa ME (2009)	1
STMN2	0	GPRASP2	0	two hybrid	Vinayagam A (2011)	1
ADRB1	3	GPRASP2	0	pull down	Simonin F (2004)	1
CALCR	0	GPRASP2	0	pull down	Simonin F (2004)	1
TBXA2R	1	GPRASP1	5	pull down	Simonin F (2004)	1
HGH1	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
OPRK1	1	GPRASP1	5	pull down	Simonin F (2004)	1
TRAF4	1	GPRASP1	5	two hybrid	Rozan LM (2006)	1
ATXN7	0	GPRASP1	5	two hybrid	Kahle JJ (2011)	1
LAMTOR5	1	GPRASP1	5	two hybrid	Stelzl U (2005)	1
OPRL1	2	GPRASP1	5	pull down	Simonin F (2004)	1
CALCR	0	GPRASP1	5	pull down	Simonin F (2004)	1
OPRM1	0	GPRASP1	5	pull down	Simonin F (2004)	1
TFG	3	GPRASP1	5	two hybrid	Stelzl U (2005)	1
OPRM1	0	4985	0	affinity chromatography technology, affinity chromatography technology	Gomes I (2000), He SQ (2011)	2
CHRM2	1	GPRASP1	5	pull down	Simonin F (2004)	1
CRIP1	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
GLYAT	3	GPRASP1	5	two hybrid	Stelzl U (2005)	1
GPRASP2	0	GPRASP1	5	affinity chromatography technology	Li S (2014)	1
CHRM1	3	GPRASP2	0	pull down	Simonin F (2004)	1
HTR7	2	GPRASP2	0	pull down	Simonin F (2004)	1
CHRM1	3	GPRASP1	5	pull down	Simonin F (2004)	1
SNAPIN	1	GPRASP1	5	two hybrid	Stelzl U (2005)	1
TAC3	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1