PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ACAP1	0	RAB11FIP3	2	affinity chromatography technology	Inoue H (2008)	1
ARF6	0	RAB11FIP3	2	pull down, imaging technique, affinity chromatography technology, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005), Inoue H (2008)	4
GRB2	2	ACAP1	0	two hybrid	Grossmann A (2015)	1
23246	0	ACAP1	0	affinity chromatography technology	Kellner M (2015)	1
ARF6	0	ACAP1	0	pull down, affinity chromatography technology	Klein S (2006), Klein S (2006)	2
RABGAP1L	4	ACAP1	0	two hybrid	Grossmann A (2015)	1
ACAP1	0	AKT1	1	affinity chromatography technology, enzymatic study	Li J (2005), Li J (2005)	2
ACAP1	0	IFFO1	0	two hybrid	Rual JF (2005)	1
ITGB1	4	ACAP1	0	affinity chromatography technology, pull down	Li J (2005), Li J (2005)	2