PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RASSF2	2	COA7	1	affinity chromatography technology	Couzens AL (2013)	1
MOB1B	0	RASSF5	2	bioid	Couzens AL (2013)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
STK4	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	10
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
RASSF2	2	SPRR2E	0	affinity chromatography technology	Hauri S (2013)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
PPP3CA	3	PTEN	24	affinity chromatography technology	Mistafa O (2010)	1
YWHAG	5	C1QBP	0	affinity chromatography technology	Jin J (2004)	1
RASSF2	2	OFD1	3	bioid	Couzens AL (2013)	1
RASSF5	2	STK3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Wang J (2011), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	7
STK3	1	MOB1A	2	enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Hirabayashi S (2008), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	4
RASSF2	2	YWHAB	1	affinity chromatography technology	Couzens AL (2013)	1
STK3	1	MOB1B	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid	Bao Y (2009), Bao Y (2009), Couzens AL (2013), Couzens AL (2013)	4
RASSF2	2	HDAC6	0	bioid	Couzens AL (2013)	1
YWHAZ	1	CEP131	9	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
RASSF2	2	CEP131	9	bioid	Couzens AL (2013)	1
RASSF2	2	AKAP9	13	bioid	Couzens AL (2013)	1
RASSF2	2	CALML3	0	affinity chromatography technology	Hauri S (2013)	1
YWHAE	0	C1QBP	0	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
MOB1B	0	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
PTEN	24	RASSF2	2	genetic interference	Vizeacoumar FJ (2013)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
YWHAB	1	STK3	1	affinity chromatography technology	Couzens AL (2013)	1
RASSF2	2	YWHAG	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Huttlin EL (2017)	3
RASSF2	2	PPP3CA	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
MOB1A	2	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
YWHAE	0	CEP131	9	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
RASSF2	2	C1QBP	0	affinity chromatography technology	Couzens AL (2013)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
YWHAB	1	C1QBP	0	affinity chromatography technology	Jin J (2004)	1
RASSF5	2	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	6
RASSF2	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
MOB1B	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
RASSF2	2	BIRC6	15	bioid	Couzens AL (2013)	1
RASSF2	2	YWHAZ	1	affinity chromatography technology	Couzens AL (2013)	1
MOB1A	2	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
MOB1A	2	RASSF5	2	bioid	Couzens AL (2013)	1
STK3	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	11
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
PTEN	24	SUV39H1	0	genetic interference	Vizeacoumar FJ (2013)	1
RASSF2	2	PRMT3	1	two hybrid	Weimann M (2013)	1
RASSF2	2	PPP1R9A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MOB1B	0	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
HDAC6	0	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
AKAP9	13	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
MOB1A	2	YWHAH	0	affinity chromatography technology	Couzens AL (2013)	1
RASSF2	2	YWHAQ	0	affinity chromatography technology	Couzens AL (2013)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
YWHAB	1	CEP131	9	affinity chromatography technology	Couzens AL (2013)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
KRAS	1	RASSF2	2	affinity chromatography technology, pull down	Vos MD (2003), Vos MD (2003)	2
RASSF2	2	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
RASSF2	2	YWHAE	0	affinity chromatography technology	Couzens AL (2013)	1
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
RASSF5	2	KRAS	1	pull down	Ortiz-Vega S (2002)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
RASSF2	2	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
RASSF2	2	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013)	2
RASSF2	2	PPP3CB	1	affinity chromatography technology	Huttlin EL (2015)	1
HDAC6	0	KDM1A	2	affinity chromatography technology	Joshi P (2013)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
RASSF5	2	RASSF2	2	pull down, two hybrid	Ortiz-Vega S (2002), Rolland T (2014)	2
AKAP9	13	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3