PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PHYHIP	2	FAM131A	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	PNPLA2	2	two hybrid	Stelzl U (2005)	1
TRIP6	2	LIMD1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TTR	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	TTR	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	WDR89	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	LIMD1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	COPS6	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	PRMT5	3	two hybrid	Stelzl U (2005)	1
PHYHIP	2	ZZEF1	5	two hybrid	Stelzl U (2005)	1
PHYHIP	2	NDRG1	2	two hybrid	Stelzl U (2005)	1
PHYHIP	2	PRKD2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	S100A13	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	MED8	0	two hybrid	Stelzl U (2005)	1
PAQR5	0	PHYHIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	ERG28	0	two hybrid	Stelzl U (2005)	1
TMEM255B	0	PHYHIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	KIF15	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANKRD12	6	PHYHIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	PPIE	1	two hybrid	Stelzl U (2005)	1
PHYHIP	2	TRIP6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	HDAC11	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	PTRH2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	SMARCC2	9	two hybrid	Stelzl U (2005)	1
PHYHIP	2	MAGED4B	0	two hybrid	Stelzl U (2005)	1
CA10	5	PHYHIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHYHIP	2	NDUFV3	2	two hybrid	Stelzl U (2005)	1
PHYHIP	2	EEF1A1	0	two hybrid	Stelzl U (2005)	1
TTR	0	ERG28	0	two hybrid	Vinayagam A (2011)	1
PHYHIP	2	METTL18	4	two hybrid	Stelzl U (2005)	1