PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	CCT2	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
CASQ2	0	CUL7	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Li X (2015)	4
OBSL1	9	VCP	6	affinity chromatography technology	Hanson D (2014)	1
FBXW8	2	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008)	13
GLMN	2	FBXW7	2	pull down	Tron AE (2012)	1
VCP	6	CUL7	4	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Hanson D (2014)	2
CUL7	4	CCT2	1	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CUL9	5	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pei XH (2011), Pei XH (2011), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007)	5
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
ANKRA2	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Nie J (2015), Nie J (2015), Nie J (2015), Nie J (2015)	4
SKP1	0	CCDC8	1	affinity chromatography technology	Hauri S (2016)	1
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
CUL7	4	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CCDC8	1	CCT2	1	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
LGALS3BP	5	CCT2	1	affinity chromatography technology	Fogeron ML (2013)	1
CCDC8	1	VCP	6	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
CASQ2	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
OBSL1	9	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
LGALS3BP	5	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
OBSL1	9	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CCDC8	1	LGALS3BP	5	affinity chromatography technology	Hanson D (2014)	1
GLMN	2	CUL9	5	affinity chromatography technology	Huttlin EL (2017)	1
ANKRA2	0	CUL7	4	affinity chromatography technology, affinity chromatography technology	Nie J (2015), Nie J (2015)	2
CASQ2	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OBSL1	9	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CCDC8	1	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
VCP	6	CDK1	0	affinity chromatography technology	Yu CC (2013)	1
CUL7	4	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
FBXW8	2	OBSL1	9	affinity chromatography technology	Litterman N (2011)	1
FBXW8	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016)	9
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
OBSL1	9	LGALS3BP	5	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	FBXW8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
TP53	0	CUL9	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nikolaev AY (2003), Nikolaev AY (2003), Nikolaev AY (2003), Nikolaev AY (2003), Nikolaev AY (2003), Becker K (2007), Dowell JD (2007), Pei XH (2011), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007), Vitali R (2008), Vitali R (2008), Kasper JS (2006), Fogeron ML (2013), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	18
HNRNPU	12	VTN	1	biochemical	Havugimana PC (2012)	1
CUL7	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Arai T (2003), Arai T (2003)	2
CUL7	4	GLMN	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arai T (2003), Arai T (2003), Huttlin EL (2017)	3
OBSL1	9	CCT2	1	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CCDC8	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
TP53	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andrews P (2006), Andrews P (2006), Andrews P (2006), Dowell JD (2007), Dowell JD (2007), Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Kim SS (2007), Kim SS (2007), Kim SS (2007), Kaustov L (2007), Kasper JS (2006), Kasper JS (2006), Kasper JS (2006), Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017), Guo H (2014)	22
TP53	0	FBXW8	2	affinity chromatography technology	Li X (2015)	1
MAPK14	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
TP53	0	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
FBXW8	2	CCT2	1	affinity chromatography technology	Litterman N (2011)	1
ANKRA2	0	OBSL1	9	affinity chromatography technology	Nie J (2015)	1
CUL7	4	VTN	1	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Huttlin EL (2017)	2
FBXW8	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Xu X (2008)	3
CDK1	0	TP53	0	enzymatic study, affinity chromatography technology	Luciani MG (2000), Ababneh M (2001)	2
TP53	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai C (2011), Dai C (2011), Dai C (2011), Dai C (2011), Fogeron ML (2013), Hanson D (2014), Hanson D (2014)	7
MAPK14	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CUL7	4	CUL7	4	affinity chromatography technology, affinity chromatography technology	Xu X (2012), Hanson D (2014)	2
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
CUL7	4	CUL9	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Skaar JR (2007), Skaar JR (2005), Skaar JR (2005)	6
CASQ2	0	FBXW8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCT2	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology	Lin YF (2012), Lin YF (2012), Yu CC (2013)	3
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
RBX1	2	GLMN	2	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, pull down	Tron AE (2012), Tron AE (2012), Duda DM (2012), Duda DM (2012), Tron AE (2012), Tron AE (2012)	6
RBX1	2	CUL7	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Dias DC (2002), Dias DC (2002), Andrews P (2006), Andrews P (2006), Huber C (2005), Huber C (2005), Xu X (2012), Nie J (2015)	9
CUL7	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Tsutsumi T (2008), Xu X (2012), Hauri S (2016)	4
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
GLMN	2	SKP1	0	pull down	Tron AE (2012)	1
CUL7	4	CDK1	0	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CUL7	4	LGALS3BP	5	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Huttlin EL (2017)	2
FBXW8	2	CCDC8	1	affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Hanson D (2014)	2