PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CNTROB	6	CEP192	5	bioid	Gupta GD (2015)	1
FGL2	0	SPATA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP135	2	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
TRIM27	2	SPATA2	2	two hybrid	Rolland T (2014)	1
SPATA2	2	BABAM1	1	affinity chromatography technology	Sowa ME (2009)	1
CEP128	1	CYLD	2	bioid	Gupta GD (2015)	1
ODF2	1	CEP192	5	bioid	Gupta GD (2015)	1
SPATA2	2	CEP72	0	two hybrid	Rual JF (2005)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
ODF2	1	SPATA2	2	bioid	Gupta GD (2015)	1
SPATA2	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Schlicher L (2016), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
XPO1	8	CNTROB	6	affinity chromatography technology	Kirli K (2015)	1
ODF2	1	APP	1	pull down	Olah J (2011)	1
PFDN4	0	PFDN6	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
CNTROB	6	SPATA2	2	bioid	Gupta GD (2015)	1
SPATA2	2	PFDN6	0	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	CASK	18	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
CEP128	1	CASK	18	bioid	Gupta GD (2015)	1
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
ODF2	1	CEP72	0	bioid	Gupta GD (2015)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
XPO1	8	GOLGA2	2	affinity chromatography technology	Kirli K (2015)	1
TNF	0	SPATA2	2	affinity chromatography technology	Schlicher L (2016)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
SHARPIN	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Draber P (2015), Elliott PR (2016)	3
CNTRL	5	SPATA2	2	bioid	Gupta GD (2015)	1
CEP135	2	CEP72	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	CEP192	5	bioid	Gupta GD (2015)	1
XPO1	8	SPATA2	2	affinity chromatography technology	Kirli K (2015)	1
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
CNTROB	6	CYLD	2	bioid	Gupta GD (2015)	1
XPO1	8	CYLD	2	affinity chromatography technology	Kirli K (2015)	1
CEP128	1	LZTS2	4	bioid	Gupta GD (2015)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
FGL2	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
SPATA2	2	UIMC1	4	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	LIN7C	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SPATA2	2	LZTS2	4	two hybrid	Rolland T (2014)	1
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
CEP128	1	CEP192	5	bioid	Gupta GD (2015)	1
SPATA2	2	GNAL	0	affinity chromatography technology	Sowa ME (2009)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
CYLD	2	CEP192	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Sowa ME (2009), Gomez-Ferreria MA (2012), Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	4
UIMC1	4	CASK	18	affinity chromatography technology	Sowa ME (2009)	1
XPO1	8	LIN7C	0	affinity chromatography technology	Kirli K (2015)	1
RNF31	3	SPATA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goto E (2017), Schlicher L (2016), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	6
SPATA2	2	PFDN4	0	affinity chromatography technology	Sowa ME (2009)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
CEP128	1	SPATA2	2	bioid	Gupta GD (2015)	1
SHARPIN	1	SPATA2	2	affinity chromatography technology	Elliott PR (2016)	1
ELAVL1	0	DUT	1	biochemical	Wan C (2015)	1
SPATA2	2	CASK	18	affinity chromatography technology	Sowa ME (2009)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
GOLGA2	2	SPATA2	2	two hybrid	Rolland T (2014)	1
TRAF2	1	SPATA2	2	two hybrid	Rual JF (2005)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
TRIM27	2	BABAM1	1	two hybrid	Rolland T (2014)	1
DUT	1	SPATA2	2	two hybrid	Rual JF (2005)	1
ODF2	1	CYLD	2	bioid	Gupta GD (2015)	1
CEP192	5	SPATA2	2	bioid	Firat-Karalar EN (2014)	1
CNTRL	5	ODF2	1	bioid	Gupta GD (2015)	1
CEP135	2	SPATA2	2	bioid	Gupta GD (2015)	1
BABAM1	1	GNAL	0	affinity chromatography technology	Sowa ME (2009)	1
CEP135	2	LZTS2	4	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	LZTS2	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP72	0	bioid	Gupta GD (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
XPO1	8	LZTS2	4	affinity chromatography technology	Kirli K (2015)	1
SPATA2	2	LIN7C	0	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	SPATA2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CNTRL	5	CEP192	5	bioid	Gupta GD (2015)	1
UIMC1	4	LIN7C	0	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	ODF2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TNF	0	affinity chromatography technology	Xin H (2011)	1
SPATA2	2	APP	1	pull down	Olah J (2011)	1
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
SPATA2	2	SSNA1	0	affinity chromatography technology	Sowa ME (2009)	1
UIMC1	4	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017), Li Y (2017)	15
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CYLD	2	bioid	Gupta GD (2015)	1
MAD1L1	2	SPATA2	2	two hybrid	Rolland T (2014)	1