PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM14	1	RBM39	2	two hybrid, bioid	Tan P (2017), Tan P (2017)	2
TRIM14	1	ACTA2	1	two hybrid, bioid	Tan P (2017), Tan P (2017)	2
PPP6C	7	WRNIP1	3	affinity chromatography technology	Tan P (2017)	1
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
TRIM14	1	PPP6C	7	two hybrid, affinity chromatography technology, bioid	Tan P (2017), Tan P (2017), Tan P (2017)	3
IKBKG	0	TRIM14	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014)	3
DDX58	3	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
RNF125	0	TRIM14	1	affinity chromatography technology, enzymatic study	Jia X (2017), Jia X (2017)	2
MAVS	1	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
TRIM14	1	WRNIP1	3	two hybrid, affinity chromatography technology	Tan P (2017), Tan P (2017)	2
TRIM14	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014), Tan P (2017), Tan P (2017)	5
TRIM14	1	USP14	1	two hybrid, bioid	Tan P (2017), Tan P (2017)	2
MAVS	1	WRNIP1	3	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
DDX58	3	TRIM14	1	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2