PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK11B	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Mikolajczyk M (2004), Mikolajczyk M (2004)	2
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
TGM2	2	RBM25	5	affinity chromatography technology	Hein MY (2015)	1
POU2F1	5	VDR	2	pull down	Kakizawa T (1999)	1
KMT2E	7	CDK11B	1	affinity chromatography technology	Ding X (2015)	1
NTRK1	1	PNKP	3	affinity chromatography technology	Emdal KB (2015)	1
PNKP	3	CDK11B	1	affinity chromatography technology	Koch CA (2004)	1
RNPS1	1	CDK11A	1	affinity chromatography technology	Loyer P (1998)	1
YWHAQ	0	HSPA8	4	affinity chromatography technology	Jin J (2004)	1
HIST1H1E	5	CDK11B	1	affinity chromatography technology	Huttlin EL (2017)	1
VDR	2	CDK11B	1	affinity chromatography technology, affinity chromatography technology	Chi Y (2009), Chi Y (2009)	2
EIF3F	1	CDK11A	1	two hybrid, affinity chromatography technology	Shi J (2003), Shi J (2003)	2
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
CDK11B	1	CCND3	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Zhang S (2002), Zhang S (2002), Zhang S (2002), Wang J (2011)	4
UHRF2	1	PIN1	0	affinity chromatography technology	Lai M (2016)	1
FGF8	0	CDK11B	1	affinity chromatography technology	Huttlin EL (2017)	1
POU2F1	5	ESR1	0	pull down	Prefontaine GG (1999)	1
CDK11B	1	RBM25	5	biochemical	Havugimana PC (2012)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
CDK11B	1	POU2F1	5	affinity chromatography technology, affinity chromatography technology	Kang J (2011), Kang J (2011)	2
YWHAB	1	RNPS1	1	affinity chromatography technology	Jin J (2004)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
NTRK1	1	RANBP9	5	affinity chromatography technology	Emdal KB (2015)	1
MEPCE	1	CSNK2A2	1	affinity chromatography technology	Jeronimo C (2007)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
PIN1	0	CDK11B	1	pull down	Ingham RJ (2005)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
TGM2	2	YWHAG	5	biochemical	Kristensen AR (2012)	1
NTRK1	1	CDK11B	1	affinity chromatography technology	Emdal KB (2015)	1
JMJD6	1	RBM25	5	affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Huttlin EL (2017)	2
YWHAG	5	CDK11B	1	affinity chromatography technology, pull down	Feng Y (2005), Feng Y (2005)	2
RANBP9	5	CDK11B	1	pull down, affinity chromatography technology, enzymatic study	Mikolajczyk M (2003), Mikolajczyk M (2003), Mikolajczyk M (2003)	3
NTRK1	1	YWHAB	1	affinity chromatography technology	Emdal KB (2015)	1
CCND3	1	VDR	2	two hybrid	Wang J (2011)	1
CDK11B	1	MSN	0	two hybrid	Wang J (2011)	1
MEPCE	1	CDK11B	1	affinity chromatography technology	Jeronimo C (2007)	1
MSN	0	HSPA4	3	biochemical	Wan C (2015)	1
EIF3F	1	CSNK2A2	1	affinity chromatography technology	Sowa ME (2009)	1
TGM2	2	YWHAZ	1	biochemical	Kristensen AR (2012)	1
NTRK1	1	CSNK2A2	1	affinity chromatography technology	Emdal KB (2015)	1
CDC37	0	HSPA8	4	affinity chromatography technology	Li J (2013)	1
CDK11B	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Mikolajczyk M (2004), Taipale M (2012)	2
ZNF221	2	CDK11B	1	affinity chromatography technology	Huttlin EL (2017)	1
JMJD6	1	CDK11B	1	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CDK11B	1	TPPP	3	two hybrid	Wang J (2011)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
YWHAB	1	CDK11B	1	affinity chromatography technology, pull down	Feng Y (2005), Feng Y (2005)	2
CDK11B	1	RAP1A	1	biochemical	Havugimana PC (2012)	1
NTRK1	1	YWHAZ	1	affinity chromatography technology	Emdal KB (2015)	1
CDK11B	1	KAT7	3	two hybrid, pull down, affinity chromatography technology, two hybrid	Zong H (2005), Zong H (2005), Zong H (2005), Wang J (2011)	4
UHRF2	1	CDK11A	1	affinity chromatography technology	Lai M (2016)	1
NTRK1	1	AP3D1	7	affinity chromatography technology	Emdal KB (2015)	1
CDK11B	1	RPS27A	1	two hybrid	Wang J (2011)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
CDC37	0	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
PIN1	0	CSNK2A2	1	pull down, affinity chromatography technology	Messenger MM (2002), Messenger MM (2002)	2
RNPS1	1	RBM25	5	affinity chromatography technology	Ewing RM (2007)	1
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
YWHAE	0	CDK11B	1	affinity chromatography technology, pull down	Feng Y (2005), Feng Y (2005)	2
TGM2	2	CDK11B	1	affinity chromatography technology	Hein MY (2015)	1
YWHAE	0	CDC37	0	affinity chromatography technology	Zuo S (2010)	1
YWHAE	0	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
RNPS1	1	CSNK2A2	1	affinity chromatography technology	Ewing RM (2007)	1
YWHAQ	0	PNKP	3	affinity chromatography technology	Ewing RM (2007)	1
HSPA8	4	TGM2	2	two hybrid	Wang J (2011)	1
CDK11A	1	RBM25	5	affinity chromatography technology	Varjosalo M (2013)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
RANBP9	5	ESR1	0	pull down	Poirier MB (2006)	1
AP2M1	5	RPS27A	1	affinity chromatography technology	Li J (2013)	1
HSPA8	4	RNPS1	1	biochemical	Havugimana PC (2012)	1
ESR1	0	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nair SC (1996), Tateishi Y (2004), Suzuki T (2011), Azuma K (2004), Azuma K (2004), Nalvarte I (2010), Dhamad AE (2016)	7
AP3D1	7	RBM25	5	biochemical	Wan C (2015)	1
CDK11A	1	CSNK2A2	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013)	2
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
NTRK1	1	MEPCE	1	affinity chromatography technology	Emdal KB (2015)	1
YWHAG	5	RNPS1	1	affinity chromatography technology	Jin J (2004)	1
NTRK1	1	RBM25	5	affinity chromatography technology	Emdal KB (2015)	1
RAP1A	1	NTRK1	1	affinity chromatography technology	Wu C (2001)	1
ZRSR2	0	JMJD6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RSBN1	3	CDK11B	1	affinity chromatography technology	Huttlin EL (2017)	1
JMJD6	1	HSPA4	3	biochemical	Kristensen AR (2012)	1
CDK11B	1	HSPA8	4	affinity chromatography technology	Mikolajczyk M (2004)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
YWHAZ	1	CDK11B	1	affinity chromatography technology, pull down	Feng Y (2005), Feng Y (2005)	2
NTRK1	1	YWHAG	5	affinity chromatography technology	Emdal KB (2015)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
RNPS1	1	CDK11B	1	affinity chromatography technology	Ewing RM (2007)	1
CDK11B	1	CDK11B	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Mikolajczyk M (2004), Mikolajczyk M (2004), Mikolajczyk M (2003)	3
ESR1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Ambrosino C (2010), Tarallo R (2011), Gebauer M (1998), Dhamad AE (2016), Dhamad AE (2016)	7
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
RNPS1	1	RANBP9	5	affinity chromatography technology	Ewing RM (2007)	1
PIN1	0	RNPS1	1	pull down	Ingham RJ (2005)	1
TGM2	2	YWHAQ	0	biochemical	Kristensen AR (2012)	1
RAP1A	1	HSPA4	3	pull down	Stoletov KV (2004)	1
CDC37	0	CDK11A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Li J (2013), Huttlin EL (2017)	4
PIN1	0	CDK11A	1	pull down	Ingham RJ (2005)	1
NTRK1	1	YWHAQ	0	affinity chromatography technology	Emdal KB (2015)	1
AP2M1	5	CDK11B	1	two hybrid	Wang J (2011)	1
HSP90AA1	7	CDK11A	1	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Huttlin EL (2017)	2
AP3D1	7	CDK11B	1	biochemical	Havugimana PC (2012)	1
UHRF2	1	CDK11B	1	affinity chromatography technology	Lai M (2016)	1
CDK11B	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mikolajczyk M (2004), Mikolajczyk M (2004), Li J (2013)	3
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
HSPA8	4	POU2F1	5	biochemical	Havugimana PC (2012)	1
CSNK2A2	1	CDK11B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CSNK2A2	1	TGM2	2	two hybrid	Wang J (2011)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
NTRK1	1	EIF3F	1	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	AP2M1	5	affinity chromatography technology	Tarallo R (2011)	1
CSNK2A2	1	CDC37	0	affinity chromatography technology	Hauri S (2016)	1
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2
YWHAQ	0	CDK11B	1	affinity chromatography technology, pull down	Feng Y (2005), Feng Y (2005)	2
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
CDK11A	1	CDK11B	1	affinity chromatography technology	Huttlin EL (2015)	1
CDK11B	1	EIF3F	1	enzymatic study	Shi J (2009)	1
MEPCE	1	YWHAZ	1	affinity chromatography technology	Jeronimo C (2007)	1
ZRSR2	0	CDK11B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK11B	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Wang Y (2009)	3
HSP90AA1	7	CSNK2A2	1	pull down	Miyata Y (1995)	1
NTRK1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2