PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF518A	5	MYH9	19	affinity chromatography technology	Hauri S (2016)	1
PCDHA12	2	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
PCDHGA5	2	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
CBX1	0	TRIM28	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Chang CW (2008), Chang CW (2008), Ryan RF (1999), Rosnoblet C (2011), Moriyama T (2015), Huttlin EL (2017), Hauri S (2016)	8
HDAC6	0	ZNF518A	5	affinity chromatography technology	Hein MY (2015)	1
CLEC11A	0	ZNF518A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF518A	5	CSTA	1	affinity chromatography technology	Hauri S (2016)	1
MYH9	19	GNG12	0	affinity chromatography technology	Hein MY (2015)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
CBX3	1	MYL12B	0	affinity chromatography technology	Hauri S (2016)	1
CBX3	1	ZNF518A	5	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
ZNF518A	5	EIF3B	3	affinity chromatography technology	Hauri S (2016)	1
APBA2	1	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
ZNF518A	5	MYL12B	0	affinity chromatography technology	Hauri S (2016)	1
HIF1A	1	TRIM28	1	affinity chromatography technology	Cai Q (2013)	1
EIPR1	1	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
HDAC6	0	HIF1A	1	affinity chromatography technology	Qian DZ (2006)	1
ZNF518A	5	GNG12	0	affinity chromatography technology	Hauri S (2016)	1
PCDH20	2	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
XPA	1	ZNF518A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCDHGB4	0	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
HDAC6	0	MYH9	19	affinity chromatography technology	Watson GW (2016)	1
CBX1	0	ZNF518A	5	affinity chromatography technology	Hauri S (2016)	1
GSTP1	0	ZNF518A	5	affinity chromatography technology	Hein MY (2015)	1
CBR1	0	ZNF518A	5	affinity chromatography technology	Hein MY (2015)	1
ZNF518A	5	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
CBX5	3	ZNF518A	5	affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Hauri S (2016)	2
BBS7	2	ZNF518A	5	affinity chromatography technology	Huttlin EL (2017)	1
ZNF518A	5	DCTN2	0	affinity chromatography technology	Hauri S (2016)	1
HIF1A	1	ZNF518A	5	affinity chromatography technology	Hein MY (2015)	1