PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LATS1	3	USP9X	15	affinity chromatography technology, biochemical	Toloczko A (2017), Toloczko A (2017)	2
NUAK1	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014)	2
NUAK1	2	S100A8	0	affinity chromatography technology	Ewing RM (2007)	1
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
LATS1	3	APP	1	pull down	Olah J (2011)	1
PPP1CC	2	NUAK1	2	two hybrid	Esteves SL (2012)	1
SRRM2	18	APP	1	pull down	Olah J (2011)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
NUAK1	2	PLK1	0	affinity chromatography technology	Banerjee S (2014)	1
NUAK1	2	SRRM2	18	affinity chromatography technology	So J (2015)	1
LATS1	3	PPP1CC	2	affinity chromatography technology	Chiyoda T (2012)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
NUAK1	2	USP9X	15	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Al-Hakim AK (2008), Al-Hakim AK (2008), Al-Hakim AK (2008), Banerjee S (2014)	4
FBXO25	1	PPP1R12A	6	affinity chromatography technology	Teixeira FR (2010)	1
NUAK1	2	3494	0	affinity chromatography technology	Ewing RM (2007)	1
FBXW11	2	PPP1CC	2	two hybrid	Wallach T (2013)	1
FBXO25	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
S100A8	0	APP	1	pull down	Olah J (2011)	1
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
NUAK1	2	PPP1R12A	6	affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014)	2
ELAVL1	0	NUAK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
FBXO25	1	NUAK1	2	enzymatic study	Teixeira FR (2013)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
NUAK1	2	PRKAR1A	4	affinity chromatography technology	Ewing RM (2007)	1
PPP1CB	9	PPP1R12C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	4
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
BTRC	1	PRKAR1A	4	affinity chromatography technology	Coyaud E (2015)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NUAK1	2	S100A9	0	affinity chromatography technology	Ewing RM (2007)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
CUL1	7	PPP1CC	2	affinity chromatography technology	Bennett EJ (2010)	1
NUAK1	2	LATS1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Humbert N (2010), Humbert N (2010), Humbert N (2010)	3
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	PRKAA1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NUAK1	2	PPP1R12C	1	affinity chromatography technology	Banerjee S (2014)	1
NUAK1	2	PPP1CB	9	affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014)	2
ELAVL1	0	PPP1CB	9	affinity chromatography technology	Abdelmohsen K (2009)	1
SRRM2	18	ELAVL1	0	affinity chromatography technology	McCracken S (2005)	1
PRKAA1	2	NUAK1	2	affinity chromatography technology	Al-Hakim AK (2005)	1
PPP1R12A	6	PPP1R12B	2	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
FBXW11	2	PRPSAP1	0	affinity chromatography technology	Low TY (2014)	1
NUAK1	2	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014), Banerjee S (2014), Huttlin EL (2017)	4
S100A9	0	S100A8	0	two hybrid, pull down	Bandyopadhyay S (2010), Vogl T (2004)	2
PPP1R12B	2	SKP1	0	biochemical	Wan C (2015)	1
LATS1	3	PPP1R12A	6	enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiyoda T (2012), Chiyoda T (2012), Chiyoda T (2012)	3
NUAK1	2	PPP1R12B	2	affinity chromatography technology	Banerjee S (2014)	1
NUAK1	2	KRT77	3	affinity chromatography technology	Ewing RM (2007)	1
ELAVL1	0	PRKAR1A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
NUAK1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014), Banerjee S (2014), Huttlin EL (2017)	4
PPP1CB	9	PPP1R12A	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Ewing RM (2007), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	7
NUAK1	2	PRPSAP1	0	affinity chromatography technology	Ewing RM (2007)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NUAK1	2	APP	1	pull down	Olah J (2011)	1
LATS1	3	PLK1	0	affinity chromatography technology	Chiyoda T (2012)	1
PPP1R12B	2	PPP1CB	9	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Fujioka M (1998), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	5
PPP1R12A	6	PPP1R12C	1	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ELAVL1	0	PPP1R12A	6	affinity chromatography technology	Abdelmohsen K (2009)	1
NUAK1	2	CUL1	7	affinity chromatography technology	Banerjee S (2014)	1
PPP1CC	2	SKP1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
ELAVL1	0	PPP1CC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP1R12A	6	CUL1	7	biochemical	Kristensen AR (2012)	1