PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ORC5	0	CDC6	0	pull down	Ramachandran N (2004)	1
MCM5	1	ORC1	3	pull down	Ramachandran N (2004)	1
CDT1	2	GRWD1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	6
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
ATM	9	MCM2	3	enzymatic study	Cortez D (2004)	1
CDT1	2	FZR1	1	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
HUWE1	22	CDC20	1	affinity chromatography technology	Hein MY (2015)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
MANSC1	4	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
ATRIP	1	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003), Cortez D (2004), Cortez D (2001), Cortez D (2001), Cortez D (2001), Cortez D (2001), Rendtlew Danielsen JM (2009), Kulkarni A (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Itakura E (2004), Itakura E (2004), Itakura E (2004), Pabla N (2008), Pabla N (2011), Collis SJ (2007), Collis SJ (2007), Warmerdam DO (2010), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Bomgarden RD (2004), Choi JH (2007), Lovejoy CA (2009), Huttlin EL (2017)	27
CCL2	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDC6	0	ATRIP	1	pull down	Yoshida K (2010)	1
CDT1	2	ORC2	0	pull down	Ramachandran N (2004)	1
CDC14A	4	CDC6	0	enzymatic study	Bremmer SC (2012)	1
PROZ	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
ORC3	3	ORC6	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004)	6
KAT7	3	CDC6	0	enzymatic study	Iizuka M (2006)	1
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
BMI1	0	AKAP8L	1	affinity chromatography technology	Cao Q (2014)	1
CDK4	2	CHEK2	2	genetic interference	Shen JP (2017)	1
MCM8	3	ORC2	0	affinity chromatography technology, affinity chromatography technology	Volkening M (2005), Volkening M (2005)	2
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
TERF1	1	MCM2	3	two hybrid	Lee OH (2011)	1
FZR1	1	UBE2K	0	pull down	Jin L (2008)	1
CDC6	0	CDKN2A	1	pull down	Ramachandran N (2004)	1
MCM10	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
ATRIP	1	MCM7	5	affinity chromatography technology	Cortez D (2004)	1
MCM5	1	ORC5	0	pull down	Ramachandran N (2004)	1
CCL2	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDC6	0	UBE2K	0	two hybrid	Wang J (2011)	1
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
PCNA	0	CHEK1	2	affinity chromatography technology	Scorah J (2008)	1
CDT1	2	CDK1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sugimoto N (2004), Sugimoto N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
CDT1	2	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teer JK (2008), Sugimoto N (2004), Sugimoto N (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
CDK4	2	MYC	2	enzymatic study, two hybrid, fluorescent resonance energy transfe	Anders L (2011), Wang J (2011), Ivanov AA (2017)	3
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
IL20RA	2	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
ATM	9	CHEK1	2	unspecified method, enzymatic study, genetic interference	Kim ST (1999), Sorensen CS (2003), Shen JP (2017)	3
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
MYC	2	NOP56	0	affinity chromatography technology	Koch HB (2007)	1
TERF1	1	CDC6	0	pull down	Tatsumi Y (2008)	1
CDT1	2	CDC6	0	pull down, pull down, imaging technique	Sugimoto N (2008), Ramachandran N (2004), Sugimoto N (2015)	3
CDK2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Craney A (2016), Huttlin EL (2017)	4
FAM131B	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNB1	3	CDKN1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amador V (2007), Garcia-Wilson E (2005), Ando T (2001), Poon RY (1996), Fogeron ML (2013), Chen TC (2014)	6
CCNB1	3	PCNA	0	affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Huttlin EL (2017)	2
HIF1A	1	LAMP2	0	affinity chromatography technology, affinity chromatography technology	Olmos G (2009), Ferreira JV (2013)	2
MYC	2	MCM7	5	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Ewing RM (2007), Koch HB (2007), Koch HB (2007), Koch HB (2007)	4
TOP1	1	WEE1	2	genetic interference	Srivas R (2016)	1
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
CHEK2	2	WEE1	2	genetic interference	Srivas R (2016)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
CDKN2A	1	MCM2	3	pull down	Ramachandran N (2004)	1
TOP2A	2	WEE1	2	genetic interference	Srivas R (2016)	1
CDKN2A	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Fatyol K (2001), Fatyol K (2001), Ivanov AA (2017)	3
CDC6	0	CDK2	0	affinity chromatography technology, enzymatic study	Saha P (1998), Jiang W (1999)	2
CHEK1	2	CDC14A	4	genetic interference	Srivas R (2016)	1
CDT1	2	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Senga T (2006), Hu J (2006), Arias EE (2006), Nishitani H (2006), Tsanov N (2014), Chandrasekaran S (2011), Coleman KE (2015), Higa LA (2006)	11
PCDHGA5	2	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
CCL2	0	ORC2	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
MAPK6	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Rodriguez J (2016), Rodriguez J (2016)	2
CDK4	2	CDC6	0	enzymatic study	Anders L (2011)	1
KAT7	3	ORC2	0	enzymatic study	Iizuka M (2006)	1
MCM7	5	MCM8	3	affinity chromatography technology	Johnson EM (2003)	1
POLA1	0	PCNA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FZR1	1	HIF1A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
CDC20	1	PCNA	0	affinity chromatography technology	Craney A (2016)	1
CDK4	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Serrano M (1993), Xiong Y (1993), Takasaki Y (2001)	3
CCNB1	3	GRWD1	3	affinity chromatography technology	Lin Z (2015)	1
CDK1	0	CDC20	1	enzymatic study, affinity chromatography technology, enzymatic study	Yudkovsky Y (2000), Huttlin EL (2017), Jia L (2016)	3
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC6	0	CDKN1A	1	pull down, imaging technique	Ramachandran N (2004), Chen TC (2014)	2
FZR1	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TOP1	1	ATM	9	unspecified method	Trzcinska AM (2002)	1
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CCNA2	1	CDC20	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Di Fiore B (2010), Di Fiore B (2010), Di Fiore B (2010), Wolthuis R (2008), Wolthuis R (2008), Ge S (2009), Townsend K (2009), Di Fiore B (2010), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Huttlin EL (2017), Izawa D (2012), Hein JB (2016)	25
CDC6	0	MYC	2	pull down	Takayama M (2000)	1
TOP1	1	CHEK1	2	genetic interference	Srivas R (2016)	1
HUWE1	22	PCNA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Markkanen E (2011), Thompson JW (2014), Choe KN (2016), Choe KN (2016), Choe KN (2016), Choe KN (2016)	6
CDC6	0	FZR1	1	pull down, enzymatic study, enzymatic study	Ke PY (2004), Petersen BO (2000), Cotto-Rios XM (2011)	3
CDC6	0	PPP2R3A	4	affinity chromatography technology, pull down	Davis AJ (2008), Davis AJ (2008)	2
CCL2	0	MCM3	2	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
TGFBR2	0	CCNB1	3	pull down	Liu JH (1999)	1
GLMP	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
PCDHB11	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	CCNB1	3	affinity chromatography technology	Bae Y (2010)	1
CDT1	2	TOP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008)	3
CDT1	2	CCNB1	3	affinity chromatography technology, pull down	Sugimoto N (2004), Sugimoto N (2004)	2
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
CDK1	0	CCNF	2	affinity chromatography technology	Kong M (2000)	1
MCM3	2	CCNE1	1	affinity chromatography technology, pull down	Li J (2011), Li J (2011)	2
GRWD1	3	CDC6	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	4
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
ATM	9	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Mu JJ (2007), Hao Z (2012)	2
CCL2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDK6	0	MYC	2	enzymatic study, fluorescent resonance energy transfe	Anders L (2011), Ivanov AA (2017)	2
CCL2	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDKN1A	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	McKenzie PP (2003), McKenzie PP (2003), Jeon Y (2007), Derjuga A (2001), Datta NS (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bresnahan WA (1996), Bendjennat M (2003), Bao GC (2006), Chen J (1996), Chen J (1996), Chen J (1996), Levkau B (1998), Poon RY (1996), Zhao J (1998), Wang J (2011), Fogeron ML (2013), Chen TC (2014)	20
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
MAPK6	1	MCM3	2	two hybrid	Vinayagam A (2011)	1
CCNA2	1	CDK6	0	affinity chromatography technology	Datta NS (1998)	1
CDKN2A	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
POLA1	0	MCM3	2	biochemical	Havugimana PC (2012)	1
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
KAT7	3	CDT1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Miotto B (2008), Miotto B (2008), Miotto B (2008), Wong PG (2010), Wong PG (2010)	5
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
KAT7	3	MCM2	3	enzymatic study	Iizuka M (2006)	1
MCM5	1	TOP2A	2	affinity chromatography technology	Drissi R (2015)	1
WEE1	2	CDC6	0	genetic interference	Srivas R (2016)	1
MCM5	1	TOP1	1	affinity chromatography technology	Drissi R (2015)	1
HUWE1	22	MCM2	3	affinity chromatography technology	Thompson JW (2014)	1
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
TERF1	1	ATM	9	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Kishi S (2001), Kishi S (2001), Kishi S (2001), Takai H (2007), Karlseder J (2004)	5
ATR	6	MCM2	3	enzymatic study	Cortez D (2004)	1
PON2	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COLEC11	0	CDC6	0	affinity chromatography technology	Huttlin EL (2015)	1
CDK6	0	MCM10	2	pull down	Ramachandran N (2004)	1
TOP3A	0	WEE1	2	genetic interference	Srivas R (2016)	1
HIF1A	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDC6	0	ORC3	3	pull down	Ramachandran N (2004)	1
CDT1	2	CDK4	2	affinity chromatography technology	Liu E (2004)	1
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
CHEK1	2	CDC6	0	genetic interference	Srivas R (2016)	1
LAMP2	0	PCNA	0	biochemical	Havugimana PC (2012)	1
FZR1	1	CDKN2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
LAMP2	0	ORC5	0	affinity chromatography technology	Huttlin EL (2017)	1
MANSC1	4	TSPAN3	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC6	0	MCM5	1	affinity chromatography technology	Hubbi ME (2013)	1
CCNF	2	CDC6	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Walter D (2016), Walter D (2016), Walter D (2016), Walter D (2016)	4
CDT1	2	CCNE1	1	affinity chromatography technology	Liu E (2004)	1
TERF1	1	MCM7	5	affinity chromatography technology	Giannone RJ (2010)	1
CHEK2	2	CDC6	0	genetic interference	Srivas R (2016)	1
CDK1	0	FZR1	1	enzymatic study, affinity chromatography technology	Gutierrez GJ (2010), Huttlin EL (2017)	2
MCM5	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
MYC	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NOP56	0	TOP2A	2	affinity chromatography technology	Hein MY (2015)	1
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MYC	2	AKAP8L	1	affinity chromatography technology	Koch HB (2007)	1
B3GALNT1	2	CDC6	0	two hybrid	Wang J (2011)	1
HIF1A	1	MCM3	2	affinity chromatography technology, affinity chromatography technology	Hubbi ME (2011), Hubbi ME (2011)	2
MCM7	5	ATR	6	affinity chromatography technology	Cortez D (2004)	1
MCM3	2	MCM5	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Chen YH (2015), Lossaint G (2013), Lossaint G (2013), Mulvaney KM (2016)	13
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
BPNT1	1	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
TOP3A	0	CHEK1	2	genetic interference	Srivas R (2016)	1
TOP1	1	CDC6	0	genetic interference	Srivas R (2016)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
MYC	2	WEE1	2	genetic interference	Toyoshima M (2012)	1
CDK6	0	MCM2	3	pull down	Ramachandran N (2004)	1
MAPK6	1	CDC6	0	affinity chromatography technology	Rodriguez J (2016)	1
HEY1	2	CDC6	0	affinity chromatography technology	Lopez-Mateo I (2016)	1
FZR1	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNA2	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Amador V (2007), Wu G (1997), Lin ML (2011), Chen J (1996), Levkau B (1998), Poon RY (1996), Fogeron ML (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
LAMP3	1	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
POLA1	0	CCNA2	1	affinity chromatography technology, enzymatic study	Dehde S (2001), Dehde S (2001)	2
CDC6	0	CDC20	1	pull down	Ke PY (2004)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
NOP56	0	TOP1	1	affinity chromatography technology	Hayano T (2003)	1
MCM2	3	MCM10	2	pull down	Ramachandran N (2004)	1
MYC	2	TOP2A	2	affinity chromatography technology	Koch HB (2007)	1
CCNB1	3	POLA1	0	enzymatic study	Dehde S (2001)	1
CDT1	2	CDC20	1	pull down	Sugimoto N (2008)	1
CDK1	0	CDC6	0	enzymatic study	Jiang W (1999)	1
MCM10	2	CDKN1A	1	pull down	Ramachandran N (2004)	1
BPNT1	1	TOP3A	0	affinity chromatography technology	Huttlin EL (2017)	1
KAT7	3	ORC1	3	affinity chromatography technology, pull down, two hybrid	Iizuka M (1999), Iizuka M (1999), Iizuka M (1999)	3
MCM10	2	MCM7	5	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Izumi M (2000), Ramachandran N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
BPNT1	1	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
UBR1	3	CDC6	0	pull down	Madura K (1993)	1
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
CDC6	0	PPP2R3B	1	two hybrid, affinity chromatography technology, pull down	Yan Z (2000), Yan Z (2000), Yan Z (2000)	3
MCM7	5	HIF1A	1	affinity chromatography technology, pull down	Hubbi ME (2011), Hubbi ME (2011)	2
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
CDT1	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liu E (2004), Sugimoto N (2004), Sugimoto N (2004), Takeda DY (2005), Varjosalo M (2013), Hein MY (2015)	6
ATM	9	HIF1A	1	enzymatic study	Cam H (2010)	1
CDK6	0	CDC6	0	enzymatic study	Anders L (2011)	1
CDT1	2	MCM2	3	pull down	Chandrasekaran S (2011)	1
HIF1A	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDKN1A	1	PCNA	0	two hybrid, pull down, pull down, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Frouin I (2003), Watanabe H (1998), Fotedar R (1996), Jonsson ZO (1998), Gulbis JM (1996), Touitou R (2001), Yu P (2001), Yu P (2001), Chen X (2007), Chen X (2007), Wang SC (2006), Carujo S (2006), Garcia-Wilson E (2005), Howlett NG (2009), Jin Y (2008), Lee JY (2009), Ando T (2001), Ando T (2001), Takasaki Y (2001), Logette E (2011), Mistafa O (2010), Mistafa O (2010), Bruning JB (2004), Punchihewa C (2012), Mattock H (2001), Waga S (1994), Waga S (1994), Poon RY (1996), Zhang Y (1999), Warbrick E (1995), Warbrick E (1995), Poon RY (1998), Poon RY (1998), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Rizzardi LF (2014), Trombetta A (2013), Trombetta A (2013), Kim DH (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Coleman KE (2015), Huttlin EL (2017), Roessig L (2001), Roessig L (2001)	48
LAMP2	0	MCM7	5	biochemical	Havugimana PC (2012)	1
CHEK1	2	CDKN1A	1	affinity chromatography technology	Tian H (2002)	1
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
CCNF	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Choudhury R (2016), Choudhury R (2016), Choudhury R (2016)	3
CDK1	0	CHEK1	2	affinity chromatography technology	Hein MY (2015)	1
CDK1	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amador V (2007), Ando T (2001), Lin ML (2011), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
CDK2	0	TOP1	1	affinity chromatography technology	Neganova I (2011)	1
CDC20	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology	Amador V (2007), Fogeron ML (2013)	2
TOP2A	2	BMI1	0	affinity chromatography technology	Alchanati I (2009)	1
MAPK6	1	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
CDC6	0	MCM3	2	affinity chromatography technology, biochemical, pull down	Fujita M (1999), Mendez J (2000), Ramachandran N (2004)	3
CHEK1	2	POLA1	0	affinity chromatography technology	Taricani L (2009)	1
TSPAN3	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC6	0	MCM10	2	pull down	Ramachandran N (2004)	1
MYC	2	TOP1	1	affinity chromatography technology	Koch HB (2007)	1
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
CDC6	0	ATM	9	pull down	Yoshida K (2010)	1
CDKN2A	1	CDK6	0	unspecified method, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Fahraeus R (1996), Russo AA (1998), Kaldis P (2001), Yarbrough WG (1999), Della Torre G (2001), Ezhevsky SA (1997), Ezhevsky SA (1997), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Souza-Rodrigues E (2007), Huttlin EL (2015), Huttlin EL (2017), Ivanov AA (2017)	15
CHEK1	2	WEE1	2	genetic interference, genetic interference	Srivas R (2016), Srivas R (2016)	2
ATRIP	1	MCM2	3	affinity chromatography technology	Izawa N (2011)	1
ATRIP	1	ATM	9	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
ORC2	0	CCNA2	1	affinity chromatography technology	Mendez J (2002)	1
MAPK6	1	MCM7	5	affinity chromatography technology	Rodriguez J (2016)	1
WEE1	2	MCM2	3	affinity chromatography technology	Boldt K (2016)	1
ORC6	0	CDC6	0	pull down	Ramachandran N (2004)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
MYC	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Koshiji M (2004), Koshiji M (2004), Ivanov AA (2017)	3
WEE1	2	FZR1	1	genetic interference	Srivas R (2016)	1
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
NOP56	0	CDC6	0	affinity chromatography technology	Hein MY (2015)	1
CDK1	0	WEE1	2	enzymatic study	Watanabe N (2004)	1
CCNB1	3	CCNF	2	affinity chromatography technology	Kong M (2000)	1
CDT1	2	ORC1	3	pull down	Ramachandran N (2004)	1
CDKN2A	1	ATR	6	affinity chromatography technology	Rocha S (2005)	1
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
CHEK2	2	CDC14A	4	genetic interference	Srivas R (2016)	1
MCM5	1	ORC2	0	two hybrid, two hybrid, biochemical	Kneissl M (2003), Kneissl M (2003), Wan C (2015)	3
FZR1	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CCNE1	1	CDC6	0	enzymatic study	Jiang W (1999)	1
PCNA	0	TOP1	1	affinity chromatography technology	Takasaki Y (2001)	1
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
CCNA2	1	FZR1	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Jin L (2008), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Williamson A (2011), Huttlin EL (2017), Choudhury R (2016)	8
CDK2	0	POLA1	0	enzymatic study, affinity chromatography technology, enzymatic study	Matsuo K (2000), Dehde S (2001), Dehde S (2001)	3
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
TOP3A	0	CDC6	0	genetic interference	Srivas R (2016)	1
TNFRSF8	2	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC20	1	CCNB1	3	enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Garnett MJ (2009), ODonovan KJ (2010), Ke PY (2004), Braunstein I (2007), van Zon W (2010), van Zon W (2010), Pfleger CM (2001), Wolthuis R (2008), Kwan PS (2013), Tian W (2012), Han JS (2013), Lim HJ (2013), Han JS (2014), Brown NG (2014), Townsend K (2009), Sedgwick GG (2013), Lara-Gonzalez P (2011), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Wu T (2010), Uzunova K (2012), Shoji S (2014), Sedgwick GG (2013), Lara-Gonzalez P (2011), Diaz-Martinez LA (2015), Brown NG (2015), Lischetti T (2014), Tipton AR (2013), Lee SB (2015), Lee SB (2015), Jia L (2016)	33
CCNF	2	CDC20	1	affinity chromatography technology	Choudhury R (2016)	1
CDC6	0	PSKH1	0	pull down, affinity chromatography technology	Petersen BO (1999), Petersen BO (1999)	2
CDK4	2	MCM2	3	pull down	Ramachandran N (2004)	1
MCM7	5	GRWD1	3	imaging technique	Sugimoto N (2015)	1
MAGEA10	1	PON2	0	affinity chromatography technology	Hein MY (2015)	1
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
TNFRSF10A	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	ATR	6	affinity chromatography technology	Huttlin EL (2017)	1
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
MCM3	2	MCM10	2	pull down	Ramachandran N (2004)	1
TOP2A	2	CHEK1	2	genetic interference	Srivas R (2016)	1
CDK1	0	POLA1	0	enzymatic study	Dehde S (2001)	1
ATM	9	BMI1	0	affinity chromatography technology, affinity chromatography technology	Facchino S (2010), Pan MR (2011)	2
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
CDC14A	4	FZR1	1	enzymatic study	Bembenek J (2001)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
TOP2A	2	CDC6	0	genetic interference	Srivas R (2016)	1
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MYC	2	POLA1	0	genetic interference	Toyoshima M (2012)	1
POLA1	0	CCNE1	1	affinity chromatography technology	Dehde S (2001)	1
AKAP8L	1	CDC6	0	affinity chromatography technology	Martins S (2003)	1
CDC6	0	ORC1	3	two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004)	7
CDC6	0	HUWE1	22	two hybrid, pull down, affinity chromatography technology	Hall JR (2007), Hall JR (2007), Hall JR (2007)	3
TGFBR2	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TNFRSF1A	3	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
MCM10	2	ORC3	3	pull down	Ramachandran N (2004)	1
CCNB1	3	CDC14A	4	affinity chromatography technology	Paulsen MT (2006)	1
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
FAM131B	0	TOP2A	2	affinity chromatography technology	Huttlin EL (2017)	1
MCM7	5	ORC3	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
TOP1	1	GRWD1	3	unspecified method	Trzcinska AM (2002)	1
ORC1	3	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mendez J (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
PCNA	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLA1	0	MCM2	3	affinity chromatography technology	Dehde S (2001)	1
CDKN1A	1	CDK6	0	affinity chromatography technology, pull down, affinity chromatography technology	Selma Dagtas A (2010), Ramachandran N (2004), Huttlin EL (2017)	3
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
CDC6	0	ATR	6	pull down, affinity chromatography technology	Yoshida K (2010), Yoshida K (2010)	2
FZR1	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ATR	6	PPP2R3A	4	unspecified method	Kim ST (1999)	1
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
CDC6	0	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Petersen BO (1999), Petersen BO (1999), Saha P (1998), Jiang W (1999)	4
CDC6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Hubbi ME (2013), Hubbi ME (2013)	2
MCM5	1	CDKN2A	1	pull down	Ramachandran N (2004)	1
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
PCNA	0	MCM7	5	affinity chromatography technology	Han J (2014)	1
CDKN2A	1	TOP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Ayrault O (2004), Ayrault O (2003), Ayrault O (2003)	3
MAPK6	1	AKAP8L	1	affinity chromatography technology	Rodriguez J (2016)	1
MCM8	3	CDC6	0	affinity chromatography technology, affinity chromatography technology	Volkening M (2005), Volkening M (2005)	2
ATR	6	CHEK2	2	enzymatic study, enzymatic study, genetic interference	Olson E (2006), Matsuoka S (2000), Srivas R (2016)	3
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
ORC2	0	MCM10	2	two hybrid, affinity chromatography technology, pull down	Izumi M (2000), Izumi M (2000), Ramachandran N (2004)	3
CDC6	0	BMI1	0	affinity chromatography technology	Agherbi H (2009)	1
CCNA2	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Huttlin EL (2015), Huttlin EL (2017)	3
HUWE1	22	CDK1	0	affinity chromatography technology	Thompson JW (2014)	1
CDC6	0	POLA1	0	biochemical	Wan C (2015)	1
CDK4	2	TOP1	1	genetic interference	Shen JP (2017)	1
MCM7	5	CDT1	2	imaging technique	Sugimoto N (2015)	1
CDKN2A	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3
CDT1	2	TOP2A	2	pull down, affinity chromatography technology, affinity chromatography technology	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008)	3
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
ISLR	0	CDC6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
MAGEA10	1	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
LAMP2	0	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	CDC6	0	two hybrid	Saha P (1998)	1