PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SGSM2	2	PNO1	0	two hybrid	Stelzl U (2005)	1
HNRNPL	3	CHD3	19	affinity chromatography technology	Fei T (2017)	1
SGSM2	2	EGFR	5	two hybrid	Stelzl U (2005)	1
SGSM2	2	FNBP1L	2	two hybrid	Stelzl U (2005)	1
SGSM2	2	MPP1	1	two hybrid	Stelzl U (2005)	1
SGSM2	2	RPS25	0	two hybrid	Stelzl U (2005)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
SGSM2	2	RGMA	2	two hybrid	Stelzl U (2005)	1
SGSM2	2	KHDRBS3	0	two hybrid	Stelzl U (2005)	1
SGSM2	2	AFP	1	two hybrid	Stelzl U (2005)	1
SGSM2	2	CA12	1	two hybrid	Stelzl U (2005)	1
SGSM2	2	GDPD2	0	two hybrid	Stelzl U (2005)	1
SGSM2	2	CELSR3	16	two hybrid	Stelzl U (2005)	1
PTPRN	3	SGSM2	2	affinity chromatography technology	Huttlin EL (2017)	1
SGSM2	2	CHD3	19	two hybrid	Stelzl U (2005)	1
EGFR	5	PNO1	0	affinity chromatography technology	Tong J (2014)	1
PTN	0	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
HNRNPL	3	FNBP1L	2	affinity chromatography technology	Fei T (2017)	1
CETN1	0	SGSM2	2	affinity chromatography technology	Huttlin EL (2017)	1
SGSM2	2	PTN	0	two hybrid	Stelzl U (2005)	1
HNRNPL	3	SGSM2	2	affinity chromatography technology	Fei T (2017)	1