PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBTD1	0	UBE2D3	1	two hybrid, biochemical, affinity chromatography technology	Uhler JP (2013), Uhler JP (2013), Uhler JP (2013)	3
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
UBE2I	0	RNF10	0	two hybrid	Markson G (2009)	1
XPO1	8	SETDB1	3	affinity chromatography technology	Kirli K (2015)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
EEF1A1	0	HSP90AA1	7	affinity chromatography technology	Aranda-Orgilles B (2008)	1
UBE2D1	0	RNF10	0	two hybrid	Markson G (2009)	1
UBE2J2	1	RNF10	0	two hybrid	Markson G (2009)	1
SNCA	0	RNF10	0	pull down	Schnack C (2008)	1
MEOX2	2	RNF10	0	two hybrid, pull down, affinity chromatography technology	Lin J (2005), Lin J (2005), Lin J (2005)	3
MOV10	6	RNF10	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	UBE2O	5	affinity chromatography technology	Castello A (2012)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
RNF10	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
RNF10	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
RNF10	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
UBE2E3	0	RNF10	0	two hybrid, affinity chromatography technology	Markson G (2009), Huttlin EL (2017)	2
EGLN3	0	RNF10	0	affinity chromatography technology	Rodriguez J (2016)	1
TARDBP	4	ENO1	3	affinity chromatography technology	Davis SA (2018)	1
SNCA	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
HSP90AA1	7	SNCA	0	pull down	Falsone SF (2009)	1
UBE2D2	0	RNF10	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TARDBP	4	RNF10	0	affinity chromatography technology	Freibaum BD (2010)	1
TERF1	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
MDM2	2	EEF1A1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Frum R (2007), Frum R (2007), Frum R (2007), Tsai NP (2012), Tsai NP (2012)	5
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	RNF10	0	affinity chromatography technology	Taipale M (2012)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
ENO1	3	RNF10	0	affinity chromatography technology	Castello A (2012)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
MDM2	2	RNF10	0	two hybrid	Woodsmith J (2012)	1
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
MDM2	2	UBE2E2	1	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2D3	1	TRIM26	1	two hybrid	Markson G (2009)	1
UBE2V1	0	RNF10	0	two hybrid	Markson G (2009)	1
UBTD1	0	UBE2D2	0	two hybrid, biochemical	Uhler JP (2013), Uhler JP (2013)	2
MOV10	6	EEF1A1	0	affinity chromatography technology	Castello A (2012)	1
UBE2E1	1	RNF10	0	two hybrid	Markson G (2009)	1
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
NXF1	0	EEF1A1	0	affinity chromatography technology	Castello A (2012)	1
MDM2	2	UBE2E3	0	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
UBE2D1	0	TRIM26	1	two hybrid	Markson G (2009)	1
MDM2	2	SETDB1	3	two hybrid	Wang J (2011)	1
RNF10	0	CCDC90B	2	two hybrid	Stelzl U (2005)	1
XPO1	8	UTP14A	0	affinity chromatography technology	Kirli K (2015)	1
UBE2W	0	RNF10	0	two hybrid	Markson G (2009)	1
KDM1A	2	CCDC90B	2	two hybrid	Stelzl U (2005)	1
KDM1A	2	XPO1	8	genetic interference	Horlbeck MA (2018)	1
UBE2E2	1	RNF10	0	two hybrid	Markson G (2009)	1
TARDBP	4	MOV10	6	affinity chromatography technology	Freibaum BD (2010)	1
TRIM26	1	RNF10	0	two hybrid	Woodsmith J (2012)	1
UBE2O	5	RNF10	0	two hybrid	Markson G (2009)	1
UBTD1	0	UBE2D1	0	biochemical	Uhler JP (2013)	1
TERF1	1	RNF10	0	two hybrid	Lee OH (2011)	1
HSP90AA1	7	SETDB1	3	affinity chromatography technology	Taipale M (2012)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
RNF10	0	UTP14A	0	two hybrid	Stelzl U (2005)	1
XPO1	8	RNF10	0	affinity chromatography technology	Kirli K (2015)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2O	5	UBE2D3	1	pull down	Xu Y (2017)	1
UBE2I	0	NXF1	0	affinity chromatography technology	Hein MY (2015)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
UBE2U	0	RNF10	0	two hybrid	Markson G (2009)	1
UBTD1	0	UBE2D4	0	two hybrid	Uhler JP (2013)	1
GRB2	2	ENO1	3	two hybrid	Wang J (2008)	1
UBE2H	3	RNF10	0	two hybrid	Markson G (2009)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TERF1	1	KDM1A	2	two hybrid	Weimann M (2013)	1
UBE2I	0	SETDB1	3	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	KDM1A	2	affinity chromatography technology	Rodriguez J (2016)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
NXF1	0	RNF10	0	affinity chromatography technology	Castello A (2012)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
TARDBP	4	HSP90AA1	7	affinity chromatography technology	Zhang YJ (2010)	1
TARDBP	4	SETDB1	3	two hybrid	Stelzl U (2005)	1
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	RNF10	0	two hybrid	Wang J (2008)	1
XPO1	8	TRIM26	1	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
MOV10	6	SETDB1	3	affinity chromatography technology	Castello A (2012)	1
RNF10	0	TLE1	6	two hybrid	Stelzl U (2005)	1
UBE2D3	1	RNF10	0	two hybrid	Markson G (2009)	1
TARDBP	4	NXF1	0	affinity chromatography technology	Freibaum BD (2010)	1
TARDBP	4	UBE2E3	0	two hybrid, affinity chromatography technology	Hans F (2014), Hans F (2014)	2
TARDBP	4	EEF1A1	0	affinity chromatography technology	Davis SA (2018)	1
UBE2D4	0	RNF10	0	two hybrid	Markson G (2009)	1
UBE2D2	0	TRIM26	1	two hybrid	Markson G (2009)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
UBE2U	0	MDM2	2	two hybrid	van Wijk SJ (2009)	1
RNF10	0	KDM1A	2	two hybrid	Weimann M (2013)	1
KDM1A	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
NXF1	0	HSP90AA1	7	affinity chromatography technology	Castello A (2012)	1
UBTD1	0	RNF10	0	two hybrid	Uhler JP (2013)	1
SHMT2	3	RNF10	0	affinity chromatography technology	Castello A (2012)	1