PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNRC6C	3	PAN3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chekulaeva M (2011), Braun JE (2011), Braun JE (2011)	3
PAN2	3	ZEB1	3	affinity chromatography technology, affinity chromatography technology	Zhou Z (2017), Zhou Z (2017)	2
PAN2	3	PAN3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uchida N (2004), Sowa ME (2009), Bett JS (2013), Jonas S (2014)	4
PAN2	3	CCT7	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bett JS (2013)	2
PAN2	3	PLEC	39	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bett JS (2013)	2
PAN2	3	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Uchida N (2004), Ezzeddine N (2007), Bett JS (2013)	3
ZFP36	2	PAN2	3	affinity chromatography technology, affinity chromatography technology	Clement SL (2011), Clement SL (2011)	2
TNRC6C	3	PABPC1	5	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huntzinger E (2010), Jinek M (2010), Jinek M (2010), Fabian MR (2009), Chekulaeva M (2011), Chekulaeva M (2011), Huang KL (2013), Braun JE (2011)	8
ZFP36	2	PABPC1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kedar VP (2010), Kedar VP (2010), Kedar VP (2010), Clement SL (2011)	4
TNRC6C	3	PAN2	3	affinity chromatography technology, affinity chromatography technology	Chekulaeva M (2011), Braun JE (2011)	2
PAN3	1	PABPC1	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Funakoshi Y (2007), Funakoshi Y (2007), Funakoshi Y (2007), Ezzeddine N (2007), Huang KL (2013)	5