PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAFB	1	ZWINT	1	two hybrid	Wang J (2011)	1
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
FOS	0	MAF	4	affinity chromatography technology, fluorescent resonance energy transfe	Annunziata CM (2011), Reinke AW (2013)	2
IKBKE	2	IRF3	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Friedman CS (2008), Nakhaei P (2012), Bharaj P (2016), Zhang Q (2017)	4
MAFB	1	BACH1	3	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFB	1	MAF	4	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
KDM6A	8	NCOA6	6	affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Lee J (2008)	2
MAFB	1	IRF7	2	affinity chromatography technology	Kim H (2010)	1
MAF	4	HOXD12	1	pull down	Kataoka K (2001)	1
MAFB	1	MAFB	1	two hybrid, two hybrid, two hybrid, fluorescent resonance energy transfe, two hybrid	Kim JC (2004), Chang NS (2005), Mu ZM (2002), Reinke AW (2013), Chang NS (2003)	5
MAF	4	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFB	1	IKBKE	2	affinity chromatography technology	Kim H (2010)	1
ATF4	2	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	3
MAFB	1	PAX6	3	affinity chromatography technology	Scoville DW (2015)	1
ATF4	2	KAT2B	2	pull down	Cherasse Y (2007)	1
MAFB	1	RBBP5	3	affinity chromatography technology	Scoville DW (2015)	1
MAFB	1	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAF	4	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFB	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFB	1	NCOA6	6	affinity chromatography technology	Scoville DW (2015)	1
ATF4	2	FOSL1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFB	1	FOS	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
HOXD12	1	MAFB	1	pull down	Kataoka K (2001)	1
MAFB	1	IRF3	4	affinity chromatography technology, affinity chromatography technology	Kim H (2010), Kim H (2010)	2
MAFB	1	KAT2B	2	affinity chromatography technology	Scoville DW (2015)	1
KDM6A	8	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Cho YW (2007), De Santa F (2007)	3
DDB1	6	MAFB	1	two hybrid	Ravasi T (2010)	1
NCOA6	6	RBBP5	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goo YH (2003), Goo YH (2003), Goo YH (2003), Lee J (2008), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Tang Z (2013)	9
RBBP5	3	DDB1	6	affinity chromatography technology	Higa LA (2006)	1
MAFB	1	ZDHHC2	1	two hybrid	Ravasi T (2010)	1
MAFB	1	KDM6A	8	affinity chromatography technology	Scoville DW (2015)	1
MAFB	1	ISL1	2	affinity chromatography technology	Scoville DW (2015)	1
MAFB	1	ZFP64	4	two hybrid	Ravasi T (2010)	1
NCOA6	6	FOS	0	pull down	Lee SK (2000)	1