PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
RELA	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Yang W (2012), Yang W (2012)	2
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
CDC34	3	CUL3	17	pull down	Plafker KS (2009)	1
HIF1A	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chew EH (2007), Sufan RI (2006), Luo W (2010), Heir P (2013), Russell RC (2008)	5
FBXW2	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xu J (2017), Xu J (2017), Xu J (2017), Huttlin EL (2017)	4
TRIM29	2	CDC34	3	pull down	Xing J (2016)	1
HIF1A	1	FBXW7	2	affinity chromatography technology	Cassavaugh JM (2011)	1
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
CDK9	3	CSNK2B	5	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Claudio PP (2006)	2
RAD21	3	CDK9	3	affinity chromatography technology	Panigrahi AK (2011)	1
UBE2D3	1	RELA	1	enzymatic study	Ryo A (2003)	1
CDC34	3	SIAH1	2	two hybrid	Rolland T (2014)	1
CDC34	3	CUL2	3	pull down	Sandoval D (2014)	1
PPARA	1	CDC34	3	pull down	Gao J (2015)	1
CDC34	3	HIF1A	1	enzymatic study	Miller F (2005)	1
BTRC	1	UBE2D3	1	pull down	Chong RA (2014)	1
FBXO32	2	CDC34	3	pull down	Csibi A (2009)	1
CSNK2B	5	PPP1CB	9	two hybrid	Wallach T (2013)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
RBX1	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down	Ohta T (2001), Sung CK (2011), DAngiolella V (2010), Kaur M (2012), Amir RE (2004), Tan M (2010), Lan L (2012), Banks D (2006), Saha A (2008), Furukawa M (2000), Gallegos JR (2008), Duan S (2011), He F (2013), Cui Y (2011), Teixeira FR (2013), Vinas-Castells R (2013), Chen Y (2009), Oda H (2010), Pick E (2007), Morimoto M (2003), Kim K (2013), Zhao D (2010), Jiang H (2005), Furukawa M (2005), Thirunavukarasou A (2015), Antonioli M (2014), Li D (2015), Watanabe K (2015), Niikura Y (2015), Zha Z (2015), Walter D (2016), Han XR (2016), Yi J (2015), Kim JH (2015), Moghe S (2012), Xu X (2008), Kuang P (2016), Kuang P (2016), Kuang P (2016), Kuchay S (2017), Xiao J (2015), McGourty CA (2016)	42
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
ITCH	1	CDC34	3	pull down	Sheng Y (2012)	1
CDC34	3	CREM	1	two hybrid	Pati D (1999)	1
ITCH	1	USP5	2	affinity chromatography technology	OConnor HF (2015)	1
NEDD4L	3	CDC34	3	pull down	Sheng Y (2012)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
PPP1CC	2	CDC34	3	affinity chromatography technology	Flores-Delgado G (2007)	1
RBX1	2	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
CUL3	17	PPP1CB	9	affinity chromatography technology	Bennett EJ (2010)	1
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
PRKN	1	CUL1	7	affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	3
FBXW11	2	CDC34	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu K (2010), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	5
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
ING4	1	CDC34	3	pull down, pull down	Hou Y (2013), Hou Y (2013)	2
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
HIF1A	1	RBX1	2	affinity chromatography technology	Heir P (2013)	1
FBXW7	2	RELA	1	affinity chromatography technology	Fekrmandi F (2015)	1
SKP2	2	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang W (2003), Sitry D (2002), Fujita N (2002), Ji P (2006), Zancai P (2005), Ji P (2004), Iovine B (2011), Calvisi DF (2009), Spruck C (2001), Bashir T (2010), Bashir T (2010), Li P (2004), Boutonnet C (2010), Rosner M (2004), Rosner M (2004), Carrano AC (1999), Carrano AC (1999), Carrano AC (1999), Wu J (2012), Strohmaier H (2001), Rodier G (2008), Rodier G (2008), Ooi LC (2013), Yumimoto K (2013), Ooi LC (2013), Cen B (2010), Enchev RI (2012), Yumimoto K (2012), Shi P (2011), Lovisa S (2016), Cen B (2009), Chan CH (2013), Ma X (2017)	33
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
PPP1CB	9	CDC34	3	affinity chromatography technology	Flores-Delgado G (2007)	1
UBE2D3	1	ZNRF1	1	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RELA	1	PPARA	1	pull down	Delerive P (1999)	1
CDC34	3	BTRC	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, bioid, affinity chromatography technology	Semplici F (2002), Cenciarelli C (1999), Sowa ME (2009), Fernandez-Sanchez ME (2010), Chong RA (2014), Burrows AC (2012), Coyaud E (2015), Huttlin EL (2017)	8
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
TBL1X	1	SIAH1	2	affinity chromatography technology	Matsuzawa SI (2001)	1
CDC34	3	ZFAND6	0	two hybrid	Duan W (2000)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
PPARG	0	CDC34	3	pull down, pull down	Hou Y (2012), Hou Y (2013)	2
FBXL2	2	CDC34	3	pull down	Kuchay S (2013)	1
RELA	1	UBC	7	affinity chromatography technology	Schweitzer K (2015)	1
ING4	1	RELA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, pull down	Garkavtsev I (2004), Garkavtsev I (2004), Nozell S (2008), Nozell S (2008), Hou Y (2013), Hou Y (2013), Hou Y (2013), Hou Y (2013)	8
TBL1X	1	RELA	1	affinity chromatography technology, affinity chromatography technology	Ramadoss S (2011), Ramadoss S (2011)	2
PPP1CB	9	TRIM28	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Li X (2010), Li X (2010), Li X (2010), Li X (2010)	4
CDC34	3	CDC34	3	enzymatic study, enzymatic study, enzymatic study	Gazdoiu S (2005), Baboshina OV (1996), David Y (2010)	3
CDC34	3	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Vingill S (2016)	2
WARS	3	CDC34	3	biochemical	Kristensen AR (2012)	1
CSNK2B	5	RNF7	0	two hybrid, pull down, affinity chromatography technology, two hybrid	Ahn BH (2001), Ahn BH (2001), Kim YS (2002), Son MY (1999)	4
FBXO7	1	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
UBE2D3	1	MUL1	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Jung JH (2011), Ni G (2017)	3
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
FBXO7	1	PIM1	2	enzymatic study	Teixeira FR (2016)	1
RAD21	3	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
RNF7	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Duan H (2001), Duan H (2001)	2
USP5	2	CDC34	3	biochemical	Kristensen AR (2012)	1
FBXO7	1	PPP1CB	9	enzymatic study	Teixeira FR (2016)	1
FBXW11	2	PPP1CC	2	two hybrid	Wallach T (2013)	1
UBC	7	SDCBP	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CUL1	7	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
WARS	3	GNPDA1	1	biochemical	Kristensen AR (2012)	1
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
FBXO32	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Yacoub N (2016), Al-Yacoub N (2016), Reitsma JM (2017)	3
FBXW11	2	UBE2D3	1	pull down	Wu K (2010)	1
TRIM21	0	CDKN1B	1	affinity chromatography technology	Sabile A (2006)	1
TRIM28	1	UBE2D3	1	pull down	Doyle JM (2010)	1
CDK9	3	TRIM28	1	affinity chromatography technology	Jeronimo C (2007)	1
FBXW7	2	CDC34	3	pull down	Klotz K (2009)	1
SDCBP	0	SIAH1	2	two hybrid	Rolland T (2014)	1
FBXW11	2	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Suzuki H (2000), Tan P (1999), Suzuki H (1999), Suzuki H (1999), Herter JR (2002), Chong RA (2014), Herter JR (2002), Huttlin EL (2015), Huttlin EL (2017), Gazdoiu S (2007)	10
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
FBXW11	2	TRIM21	0	pull down, affinity chromatography technology	Sabile A (2006), Sabile A (2006)	2
CDK9	3	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kiernan RE (2001), Garriga J (2003)	2
CSNK2B	5	BTRC	1	affinity chromatography technology	Tsuchiya Y (2010)	1
CUL3	17	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
RNF7	0	CUL3	17	enzymatic study	Huang DT (2009)	1
CDC34	3	NFKBIA	0	enzymatic study	Wu K (2010)	1
FBXW7	2	FBXW2	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
TRIM21	0	CDC34	3	pull down	Wada K (2006)	1
UBE2D3	1	NFKBIA	0	enzymatic study, enzymatic study	Gonen H (1999), Wu K (2010)	2
RAD21	3	CDC34	3	two hybrid, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
CDC34	3	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
USP5	2	GNPDA1	1	biochemical	Kristensen AR (2012)	1
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
CDC34	3	TBL1X	1	enzymatic study	Perissi V (2004)	1
MARCH2	2	CDC34	3	pull down	Bartee E (2004)	1
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
HIF1A	1	TRIM28	1	affinity chromatography technology	Cai Q (2013)	1
TRIM28	1	CDC34	3	pull down	Doyle JM (2010)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
WWP2	7	CDC34	3	pull down	Sheng Y (2012)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
TCEANC2	0	CDC34	3	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	CDC34	3	pull down, enzymatic study, pull down	Cen B (2010), Umanskaya K (2007), Ji P (2006)	3
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
HINT1	0	RBX1	2	pull down, affinity chromatography technology, affinity chromatography technology	Cen B (2009), Cen B (2009), Cen B (2009)	3
CDC34	3	FBXW2	0	enzymatic study	Cenciarelli C (1999)	1
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC34	3	CSNK2B	5	pull down, affinity chromatography technology, enzymatic study	Block K (2001), Block K (2001), Block K (2001)	3
FBXO7	1	ATF5	4	enzymatic study	Teixeira FR (2016)	1
RELA	1	PPARG	0	affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Hou Y (2012), Hou Y (2012), Lu X (2013), Chen F (2003), Chen F (2003), Perez A (2008), Jeninga EH (2007)	7
CDC34	3	FBXO4	0	enzymatic study	Cenciarelli C (1999)	1
RAD23A	1	PRKN	1	enzymatic study, affinity chromatography technology	Scanlon TC (2009), Sarraf SA (2013)	2
PRKN	1	CDC34	3	pull down	Kazlauskaite A (2014)	1
CDC34	3	RELA	1	enzymatic study	Ryo A (2003)	1
CUL1	7	PPP1CC	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	RELA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015), Huttlin EL (2017)	3
CDC34	3	SDCBP	0	two hybrid	Rolland T (2014)	1
RNF7	0	VHL	0	affinity chromatography technology	Tan M (2008)	1
VHL	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kohroki J (2005), Kamura T (2002), Kuznetsova AV (2003), Norman JA (2006), Knauth K (2006), Kamura T (2004), Heir P (2013), Essers PB (2014), Lee SB (2016)	10
USP5	2	WARS	3	biochemical	Kristensen AR (2012)	1
VHL	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Kamura T (2001), Hacker KE (2008), Hacker KE (2008), Menon S (2008), Chew EH (2007), Ietta F (2006), Megumi Y (2005), Kamura T (2002), Kuznetsova AV (2003), Hansen WJ (2002), Cockman ME (2000), Lisztwan J (1999), Lisztwan J (1999), Sufan RI (2006), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Knauth K (2006), Lonergan KM (1998), Lai Y (2012), Miller F (2005), Mahrour N (2008), Grosfeld A (2007), Russell RC (2011), Foxler DE (2012), Bonicalzi ME (2001), Bennett EJ (2010), Kanaya K (2002), Liakopoulos D (1999), Pause A (1997), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Pause A (1999), Pause A (1999), Xin H (2011), Kamura T (2004), Kamura T (2004), Heir P (2013), Russell RC (2008), Russell RC (2008), Essers PB (2014), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Heir P (2016), Chen K (2016), Uematsu K (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	54
CDC34	3	PIM1	2	affinity chromatography technology	Cen B (2010)	1
FBXO32	2	UBE2D3	1	pull down	Lokireddy S (2011)	1
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
CUL2	3	SKP2	2	affinity chromatography technology	Kimura Y (2007)	1
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
RAD21	3	UBC	7	affinity chromatography technology	Panigrahi AK (2011)	1
FBXW2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Xu J (2017)	2
TRIM28	1	PPP1CC	2	affinity chromatography technology, affinity chromatography technology	Li X (2010), Li X (2010)	2
CDC34	3	ATF5	4	affinity chromatography technology, two hybrid	Wei Y (2008), Pati D (1999)	2
CUL1	7	WWP2	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
VHL	0	CDC34	3	pull down	Masson N (2001)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC34	3	FBXL3	1	enzymatic study	Cenciarelli C (1999)	1
CUL2	3	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
FBXW11	2	UBA1	1	affinity chromatography technology	Low TY (2014)	1
CDKN1B	1	VHL	0	genetic interference	Shen JP (2017)	1
FBXL2	2	UBE2D3	1	pull down	Kuchay S (2013)	1
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
RELA	1	CUL2	3	affinity chromatography technology, affinity chromatography technology	Geng H (2009), Wang Y (2014)	2
CDC34	3	RAD23A	1	biochemical	Kristensen AR (2012)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
RELA	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Spencer E (1999), Spencer E (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	5
FBXO32	2	RBX1	2	affinity chromatography technology	Al-Yacoub N (2016)	1
RAD23A	1	UBA1	1	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
PRKN	1	FBXO4	0	affinity chromatography technology	Gong Y (2014)	1
NFKBIA	0	RELA	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Kiernan R (2003), Kiernan R (2003), Spencer E (1999), Spencer E (1999), Hay DC (2001), Hansen SK (1994), Malek S (1998), Cohen L (1998), Robert I (2009), Sasaki CY (2005), Wu BY (1995), Fagan-Garcia K (2011), Livolsi A (2001), Van Antwerp DJ (1996), Van Antwerp DJ (1996), Krappmann D (1996), Chen Z (1995), Bottero V (2001), Wang H (2010), DiDonato J (1996), Carvalho G (2010), Carvalho G (2010), Suzuki H (1999), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Pringle LM (2011), Pringle LM (2011), Pringle LM (2011), DiDonato J (1996), Ryo A (2003), Ryo A (2003), Inan MS (2000), Burstein E (2005), Chu ZL (1996), Chu ZL (1996), Starokadomskyy P (2013), Wang J (2011), Arenzana-Seisdedos F (1995), Arenzana-Seisdedos F (1997), Wood KM (1998), Cockman ME (2006), Cockman ME (2006), Li JM (2013), Rodriguez MS (1999), Huttlin EL (2015), Hein MY (2015), Taura M (2015), Kim MY (2015), Schweitzer K (2016), Schweitzer K (2016), Hochrainer K (2015), Jiang GM (2017), Huttlin EL (2017), Kumar S (2012), Kumar S (2012)	56
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
VHL	0	TRIM28	1	pull down	Li Z (2003)	1
NEDD4L	3	RNF7	0	pull down	Persaud A (2009)	1
FBXW11	2	WARS	3	affinity chromatography technology	Low TY (2014)	1
HIF1A	1	TCEANC2	0	affinity chromatography technology	Hein MY (2015)	1
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
FBXO4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Hagens O (2006), Choo YY (2011), Liu B (2012), Jeong YT (2013), Huttlin EL (2017), Reitsma JM (2017)	8
CSNK2B	5	NFKBIA	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsuchiya Y (2010), Taylor JA (1999), Taylor JA (1999)	3
GNPDA1	1	RAD23A	1	biochemical	Kristensen AR (2012)	1
RNF7	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Tan M (2010), Kuang P (2016), Kuang P (2016), Kuang P (2016)	4
SKP2	2	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down	Roe JS (2011), Roe JS (2011), Roe JS (2011)	3
USP5	2	UBA1	1	affinity chromatography technology	Song AX (2014)	1
BTRC	1	HINT1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Shi Z (2016), Shi Z (2016), Shi Z (2016)	3
FBXW2	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu J (2017), Xu J (2017), Xu J (2017)	3
CDC34	3	CDKN1B	1	enzymatic study, unspecified method	Ryu KS (2008), Duda DM (2012)	2
RBX1	2	CDC34	3	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wu K (2002), Block K (2005), Block K (2005), Chen A (2000), Cen B (2010), Cen B (2009), DAngiolella V (2010), Spruck C (2001), Shaik S (2012), Kruiswijk F (2012), Tan M (2010), Bashir T (2010), Higa LA (2003), Kanayama A (2004), Lan L (2012), Welcker M (2011), Banks D (2006), Kumar KG (2003), Higa LA (2006), Saha A (2008), Jin J (2005), Cen B (2009), Tedesco D (2002), Choi YS (2010), Duan S (2011), Li X (2003), Wang W (2003), Gallegos JR (2008), Peschiaroli A (2009), Banerjee S (2010), Duan S (2011), Wang F (2011), Chen H (2013), Rodier G (2008), Rossi M (2013), Ungermannova D (2013), Ooi LC (2013), Ziemba A (2013), Huang H (2014), Herrero-Ruiz J (2014), Kim J (2014), Min SH (2012), Watanabe M (2011), Gao D (2010), Zhou W (2014), Canettieri G (2010), Morimoto M (2003), Chen A (2002), Pashkova N (2010), Read MA (2000), Bassermann F (2005), Duda DM (2008), Enchev RI (2012), Fukushima H (2013), Tintignac LA (2005), Ungermannova D (2005), Low TY (2014), Walter D (2016), Gao J (2015), Orthwein A (2015), Wu K (2016), Wu K (2016), Nateri AS (2004), Pierce NW (2009), Kim JH (2015), Shimizu K (2017), Gschweitl M (2016), Ibarra R (2016), Kuang P (2016), Kuang P (2016), Kuang P (2016), Ferretti LP (2016), Kuchay S (2017), Gazdoiu S (2007), Dai X (2017)	75
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
FBXL2	2	CUL2	3	affinity chromatography technology	Kuchay S (2013)	1
CDK9	3	SKP2	2	affinity chromatography technology	Kiernan RE (2001)	1
CDK9	3	HINT1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
FBXW7	2	PPP1CB	9	affinity chromatography technology	Kourtis N (2015)	1
UBE2D3	1	NEDD4L	3	pull down, pull down, pull down	Maspero E (2013), Todaro DR (2017), Wang Z (2016)	3
FBXO7	1	UBE2D3	1	pull down, pull down	Vingill S (2016), Teixeira FR (2016)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
PRKN	1	FBXW7	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Staropoli JF (2003), Staropoli JF (2003), Staropoli JF (2003), Gong Y (2014)	4
RNF7	0	CUL1	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ohta T (1999), Kawakami T (2001), Tan M (2010), Swaroop M (2001), Huang DT (2009), Kuang P (2016), Zhou W (2017)	7
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
UBC	7	PPP1CB	9	affinity chromatography technology	Matsumoto M (2005)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
UBC	7	WARS	3	pull down	Zhang X (2017)	1
GNPDA1	1	CDC34	3	biochemical	Kristensen AR (2012)	1
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
RNF7	0	CDC34	3	pull down, pull down	He H (2007), Tan M (2010)	2
RAD23A	1	WARS	3	biochemical	Kristensen AR (2012)	1
UBA1	1	CDC34	3	enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Tokgoez Z (2012), Jin J (2007), Chong RA (2014), Chong RA (2014), Wauer T (2015)	5
MARCH1	1	CDC34	3	pull down	Bartee E (2004)	1
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
CSNK2B	5	PPP1CC	2	two hybrid	Wallach T (2013)	1
CUL1	7	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
HINT1	0	CDC34	3	pull down, affinity chromatography technology, affinity chromatography technology	Cen B (2009), Cen B (2009), Cen B (2009)	3
RNF7	0	CUL2	3	two hybrid, enzymatic study	Ohta T (1999), Huang DT (2009)	2
RAD23A	1	USP5	2	affinity chromatography technology, biochemical	Scanlon TC (2009), Kristensen AR (2012)	2
FBXL3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Liu B (2012), Yumimoto K (2013), Reitsma JM (2017)	4
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
MUL1	1	CDC34	3	pull down	Ni G (2017)	1
RNF7	0	UBE2D3	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tan M (2010), Kershaw NJ (2014), Raducu M (2016), Kuang P (2016), Kuang P (2016)	5
CDK9	3	RELA	1	pull down, affinity chromatography technology	Amini S (2002), Amini S (2002)	2
RBX1	2	CDKN1B	1	enzymatic study	Duda DM (2008)	1
PIM1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Cen B (2010), Cen B (2010), Cen B (2010), Cen B (2010)	4
ZNRF1	1	CDC34	3	pull down	Markson G (2009)	1
FBXW2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Saiga T (2009), Bennett EJ (2010), Busino L (2003), Liu B (2012), Low TY (2014), Xu J (2017), Reitsma JM (2017)	8
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
CDK9	3	CDC34	3	pull down, affinity chromatography technology	Kiernan RE (2001), Kiernan RE (2001)	2
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
FBXL2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Li LQ (2016), Kuchay S (2017), Reitsma JM (2017)	4
CDKN1B	1	CUL1	7	unspecified method, pull down	Carrano AC (1999), Enchev RI (2012)	2