PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP8AP2	3	FADD	1	affinity chromatography technology	Imai Y (1999)	1
MX1	0	UBE2I	0	two hybrid, affinity chromatography technology	Brantis-de-Carvalho CE (2015), Brantis-de-Carvalho CE (2015)	2
NR3C1	2	PML	7	two hybrid	Ravasi T (2010)	1
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
SCOC	3	CASP8AP2	3	affinity chromatography technology	Huttlin EL (2017)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
HDAC1	4	CASP8AP2	3	affinity chromatography technology	Huttlin EL (2017)	1
NR3C2	4	SUMO1	0	two hybrid	Tirard M (2007)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
SREBF2	5	CASP8AP2	3	two hybrid	Bandyopadhyay S (2010)	1
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
CASP8AP2	3	SUMO2	0	pull down, affinity chromatography technology	Sun H (2012), Sun H (2012)	2
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
CASP8AP2	3	PIAS1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011)	4
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
HDAC1	4	TRIM21	0	affinity chromatography technology	Terhune SS (2010)	1
CREM	1	HDAC1	4	affinity chromatography technology, pull down, pull down	Tenbrock K (2006), Tenbrock K (2006), Tenbrock K (2006)	3
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
MX1	0	SUMO1	0	two hybrid, two hybrid, affinity chromatography technology	Engelhardt OG (2001), Brantis-de-Carvalho CE (2015), Brantis-de-Carvalho CE (2015)	3
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
UBE2I	0	NR3C1	2	enzymatic study	Ogawa H (2009)	1
CASP8AP2	3	SUMO1	0	affinity chromatography technology	Sun H (2012)	1
CASP8AP2	3	CTBP2	7	two hybrid	Wang J (2011)	1
TRIM21	0	UBE2I	0	two hybrid	Rolland T (2014)	1
MX1	0	CASP8AP2	3	two hybrid	Brantis-de-Carvalho CE (2015)	1
FADD	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down	Young JA (2011), Young JA (2011), Young JA (2011)	3
CREM	1	UBE2I	0	two hybrid	Wang J (2011)	1
SREBF2	5	UBE2I	0	affinity chromatography technology, two hybrid	Hirano Y (2003), Bandyopadhyay S (2010)	2
FAS	2	UBE2I	0	affinity chromatography technology, two hybrid, pull down, two hybrid	Becker K (1997), Wright DA (1996), Wright DA (1996), Wright DA (1996)	4
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
CTBP2	7	UBE2I	0	two hybrid	Wang J (2011)	1
PML	7	FAS	2	affinity chromatography technology	Tao RH (2011)	1
CASP10	1	CASP8AP2	3	two hybrid	McDonald ER (2004)	1
SUMO2	0	HDAC1	4	pull down	Ouyang J (2009)	1
NR3C1	2	SUMO1	0	affinity chromatography technology	Lin DY (2006)	1
CASP8AP2	3	CREM	1	two hybrid	Wang J (2011)	1
CASP8AP2	3	FAS	2	affinity chromatography technology	Imai Y (1999)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
SREBF2	5	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
BCL2L1	0	CASP8AP2	3	affinity chromatography technology	Chinnaiyan AM (1997)	1
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
NR3C1	2	CASP8AP2	3	affinity chromatography technology	Obradovic D (2004)	1
TRIM21	0	CASP8AP2	3	two hybrid	Tanaka M (2010)	1
SUMO1	0	FAS	2	two hybrid, pull down	Okura T (1996), Okura T (1996)	2
TRAF2	1	CASP8AP2	3	pull down, affinity chromatography technology	Choi YH (2001), Choi YH (2001)	2
MX1	0	PIAS1	4	two hybrid, two hybrid	Engelhardt OG (2001), Brantis-de-Carvalho CE (2015)	2
GLUL	2	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
GLUL	2	CASP8AP2	3	two hybrid	Bandyopadhyay S (2010)	1
CASP8AP2	3	CASP8	1	affinity chromatography technology	Imai Y (1999)	1
NR3C2	4	CASP8AP2	3	two hybrid	Obradovic D (2004)	1
CALM1	0	CASP8AP2	3	pull down	Shen X (2005)	1
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
CASP8AP2	3	CASP8AP2	3	affinity chromatography technology	Imai Y (1999)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
NR3C2	4	NR3C1	2	pull down, two hybrid, affinity chromatography technology	Savory JG (2001), Savory JG (2001), Moraes LA (2005)	3
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
NR3C2	4	UBE2I	0	two hybrid	Tirard M (2007)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
CASP8AP2	3	PML	7	two hybrid	Wang J (2011)	1